Publications de Jonathan Allen Sulc

Publications associées (5)

Mitochondrial genetics, signalling and stress responses

Johan Auwerx, Jia Liu, Jonathan Allen Sulc

Mitochondria are multifaceted organelles with crucial roles in energy generation, cellular signalling and a range of synthesis pathways. The study of mitochondrial biology is complicated by its own small genome, which is matrilineally inherited and not sub ...

NATURE PORTFOLIO2025

ACMSD inhibition corrects fibrosis, inflammation, and DNA damage in MASLD/MASH

Johan Auwerx, Xiaoxu Li, Jia Liu, Sandra Rodriguez Lopez, Qi Wang, Jonathan Allen Sulc, Keno Strotjohann

Background & Aims: Recent findings reveal the importance of tryptophan-initiated de novo nicotinamide adenine dinucleotide (NAD+) synthesis in the liver, a process previously considered secondary to biosynthesis from nicotinamide. The enzyme α-amino-β-carb ...

Elsevier2025

Genetic and dietary modulators of the inflammatory response in the gastrointestinal tract of the BXD mouse genetic reference population

Johan Auwerx, Kristina Schoonjans, Maroun Bou Sleiman, Alessia Perino, Xiaoxu Li, Jean-David Horacio Morel, Giorgia Benegiamo, Alexis Rapin, Alexis Maximilien Bachmann, Jonathan Allen Sulc, Johanne Gracia Anne Poisson

Inflammatory gut disorders, including inflammatory bowel disease (IBD), can be impacted by dietary, environmental, and genetic factors. While the incidence of IBD is increasing worldwide, we still lack a complete understanding of the gene-by-environment in ...

2023

High-content phenotypic analysis of a C. elegans recombinant inbred population identifies genetic and molecular regulators of lifespan

Johan Auwerx, Laurent Mouchiroud, Maroun Bou Sleiman, Xiaoxu Li, Yang Li, Elena Katsyuba, Jean-David Horacio Morel, Wen Gao, Amélia Lalou, Jonathan Allen Sulc, Gaby El Alam

Lifespan is influenced by complex interactions between genetic and environmental factors. Studying those factors in model organisms of a single genetic background limits their translational value for humans. Here, we mapped lifespan determinants in 85 C. e ...

2024

Systems genetics of metabolic health in the BXD mouse genetic reference population

Johan Auwerx, Maroun Bou Sleiman, Xiaoxu Li, Jean-David Horacio Morel, Giorgia Benegiamo, Jia Liu, Wen Gao, Amélia Lalou, Alessia De Masi, Jonathan Allen Sulc, Johanne Gracia Anne Poisson

Susceptibility to metabolic syndrome (MetS) is dependent on genetics, environment, and gene-by-environment interactions, rendering the study of underlying mechanisms challenging. The majority of experiments in model organisms do not incorporate genetic var ...

2024