Julien Léonard Duc

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Publications associées (25)

Transposable element-driven transcripts as new cancer biomarkers

Didier Trono, Julien Léonard Duc, Julien Duc, Evaristo Jose Planet Letschert, Laia Simo Riudalbas

MARY ANN LIEBERT, INC2018

DUX-family transcription factors regulate zygotic genome activation in placental mammals

Didier Trono, Sonia Verp, Julien Léonard Duc, Andrea Coluccio, Alberto De Iaco, Evaristo Jose Planet Letschert

In animal embryos, transcription is mostly silent for several cell divisions, until the release of the first major wave of embryonic transcripts through so-called zygotic genome activation (ZGA). Maternally provided ZGA-triggering factors have been identif ...

2017

The mouse genome displays highly dynamic populations of KRAB-zinc finger protein genes and related genetic units

Didier Trono, Annamaria Kauzlaric, Julien Léonard Duc, Gabriela Ecco, Marco Cassano, Michaël Imbeault

KRAB-containing poly-zinc finger proteins (KZFPs) constitute the largest family of transcription factors encoded by mammalian genomes, and growing evidence indicates that they fulfill functions critical to both embryonic development and maintenance of adul ...

Public Library of Science2017

Transposable Elements and Their KRAB-ZFP Controllers Regulate Gene Expression in Adult Tissues

Didier Trono, Priscilla Turelli, Annamaria Kauzlaric, Julien Léonard Duc, Helen Mary Rowe, Sandra Eloise Kjeldsen, Gabriela Ecco, Marco Cassano, Michaël Imbeault, Andrea Coluccio

KRAB-containing zinc finger proteins (KRAB-ZFPs) are early embryonic controllers of transposable elements (TEs), which they repress with their cofactor KAP1 through histone and DNA methylation, a process thought to result in irreversible silencing. Using a ...

Cell Press - Elsevier2016

Molecular Criteria for Defining the Naive Human Pluripotent State

Didier Trono, Julien Léonard Duc, Marc Samuel Friedli, Alexandra Iouranova, Michaël Imbeault, Evaristo Jose Planet Letschert, Julien Paul André Pontis, Haoyi Wang

Recent studies have aimed to convert cultured human pluripotent cells to a naive state, but it remains unclear to what extent the resulting cells recapitulate in vivo naive pluripotency. Here we propose a set of molecular criteria for evaluating the naive ...

Cell Press2016

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