Publications de Maxime Ayer | EPFL Graph Search

Publications associées (5)

T-cell surface modification with synthetic nanomaterials for cell-mediated delivery to the central nervous system

The future of medicine lies in therapeutic approaches that can specifically target sites of disease and induce a localized and effective therapeutic effect. Cell-mediated delivery, especially using cells of the circulatory repertoire such as T lymphocytes, ...

EPFL2017

Arginine-specific protein modification using alpha-oxo-aldehyde functional polymers prepared by atom transfer radical polymerization

Harm-Anton Klok, Frederik Roman Wurm, Maxime Ayer

The residue-specific modification of peptides and proteins is a powerful strategy for preparing biomolecular-synthetic polymer conjugates with advanced properties. This manuscript aims at expanding the present toolbox of residue-selective protein modificat ...

2011

Biotin-NeutrAvidin Mediated Immobilization of Polymer Micro- and Nanoparticles on T Lymphocytes

Harm-Anton Klok, Olivier Burri, Romain Guiet, Arne Seitz, Maxime Ayer

Cells are powerful carriers that can help to improve the delivery of nanomedicines. One approach to use cells as carriers is to immobilize the nanoparticulate cargo on the cell surface. While a plethora of chemical conjugation strategies are available to b ...

2021

Cell-mediated delivery of synthetic nano- and microparticles funding

Harm-Anton Klok, Maxime Ayer

Cell mediated delivery of synthetic nano- and microparticle based drug carriers is a very promising strategy to enhance control over the distribution of drugs and improve targeting. This article will present an overview of work, which has been done to expl ...

2017

T Cell-Mediated Transport of Polymer Nanoparticles across the Blood-Brain Barrier

Harm-Anton Klok, Olivier Burri, Romain Guiet, Arne Seitz, Maxime Ayer, Markus Schuster

Delivery of therapeutics to the central nervous system (CNS) is challenging due to the presence of the blood-brain barrier (BBB). Amongst various approaches that have been explored to facilitate drug delivery to the CNS, the use of cells that have the intr ...

WILEY2020