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David Paul Roger Romascano

Cette personne a quitté l’EPFL

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Publications associées (28)

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Structural abnormalities in the thalamus of migraineurs with aura: a multiparametric study at 3T

Alessandro Daducci, Gunnar Krüger, Cristina Granziera, Nouchine Hadjikhani, David Paul Roger Romascano, Alexis Roche

Background and objectives: The thalamus exerts a pivotal role in pain processing and cortical excitability control, and migraine is characterized by repeated pain attacks and abnormal cortical habituation to excitatory stimuli. This work aimed at studying ...

Wiley-Blackwell2013

ActiveAx(ADD): Toward non-parametric and orientationally invariant axon diameter distribution mapping using PGSE

Jean-Philippe Thiran, Alessandro Daducci, David Paul Roger Romascano, Muhamed Barakovic, Jonathan Rafael Patino Lopez

Purpose Non-invasive axon diameter distribution (ADD) mapping using diffusion MRI is an ill-posed problem. Current ADD mapping methods require knowledge of axon orientation before performing the acquisition. Instead, ActiveAx uses a 3D sampling scheme to e ...

Wiley2020

Improved statistical evaluation of group differences in connectomes by screening-filtering strategy with application to study maturation of brain connections between childhood and adolescence

Jean-Philippe Thiran, Dimitri Nestor Alice Van De Ville, Patric Hagmann, Stephan Morgenthaler, Djalel Eddine Meskaldji, David Paul Roger Romascano

Detecting local differences between groups of connectomes is a great challenge in neuroimaging, because the large number of tests that have to be performed and the impact on multiplicity correction. Any available information should be exploited to increase ...

Elsevier2015

Multicontrast MRI Quantification of Focal Inflammation and Degeneration in Multiple Sclerosis

Jean-Philippe Thiran, Cristina Granziera, Gunnar Krüger, Djalel Eddine Meskaldji, Gloria Menegaz, David Paul Roger Romascano, Alexis Roche, Guillaume Bonnier, Ying-Chia Lin

Introduction. Local microstructural pathology in multiple sclerosis patients might influence their clinical performance. This study applied multicontrast MRI to quantify inflammation and neurodegeneration in MS lesions. We explored the impact of MRI-based ...

Hindawi Publishing Corporation2015

Towards non-parametric reconstruction of axon diameter distributions using diffusion MRI and regularized discrete linear modeling

David Paul Roger Romascano

The distribution of axon diameters (ADD) is an important white matter feature: it influences action potential speed, it has been shown to evolve during development, and also to be affected during pathological processes. Diffusion Magnetic Resonance Imaging ...

EPFL2019

Robust Monte-Carlo Simulations in Diffusion-MRI: Effect of the Substrate Complexity and Parameter Choice on the Reproducibility of Results

Jean-Philippe Thiran, Erick Jorge Canales Rodriguez, Gabriel Girard, David Paul Roger Romascano, Jonathan Rafael Patino Lopez

Monte-Carlo Diffusion Simulations (MCDS) have been used extensively as a ground truth tool for the validation of microstructure models for Diffusion-Weighted MRI. However, methodological pitfalls in the design of the biomimicking geometrical configurations ...

2020

Multicontrast connectometry: A new tool to assess cerebellum alterations in early relapsing‐remitting multiple sclerosis

Jean-Philippe Thiran, Dimitri Nestor Alice Van De Ville, Alessandro Daducci, Gunnar Krüger, Djalel Eddine Meskaldji, Gloria Menegaz, Cristina Granziera, David Paul Roger Romascano, Alexis Roche, Jonas Richiardi, Ying-Chia Lin, Guillaume Bonnier

Background: Cerebellar pathology occurs in late multiple sclerosis (MS) but little is known about cerebellar changes during early disease stages. In this study, we propose a new multicontrast “connectometry” approach to assess the structural and functional ...

Wiley-Blackwell2015

Migraineurs without aura show microstructural abnormalities in the cerebellum and frontal lobe

Alessandro Daducci, Gunnar Krüger, Cristina Granziera, Nouchine Hadjikhani, David Paul Roger Romascano, Alexis Roche

The involvement of the cerebellum in migraine pathophysiology is not well understood. We used a biparametric approach at high-field MRI (3 T) to assess the structural integrity of the cerebellum in 15 migraineurs with aura (MWA), 23 migraineurs without aur ...

Springer US2013

Cerebellar Connectomics Provide New Biomarkers in Early Multiple Sclerosis

Jean-Philippe Thiran, Dimitri Nestor Alice Van De Ville, Alessandro Daducci, Cristina Granziera, Gunnar Krüger, Djalel Eddine Meskaldji, Jonas Richiardi, Gloria Menegaz, David Paul Roger Romascano, Alexis Roche, Guillaume Bonnier, Ying-Chia Lin

The cerebellum is involved in multiple sclerosis (MS), but its implication in early phases is still poorly understood. We investigated structural and functional cerebellar connectivity alterations in early and minimally impaired MS patients, and their corr ...

2014

Sparse wars: A survey and comparative study of spherical deconvolution algorithms for diffusion MRI

Jean-Philippe Thiran, Erick Jorge Canales Rodriguez, Gabriel Girard, David Paul Roger Romascano, Jonathan Rafael Patino Lopez, Alessandro Daducci, Muhamed Barakovic, Marco Pizzolato, Gaëtan Olivier D Rensonnet

Spherical deconvolution methods are widely used to estimate the brain's white-matter fiber orientations from diffusion MRI data. In this study, eight spherical deconvolution algorithms were implemented and evaluated. These included two model selection tech ...

2019

Orientation invariant and non-parametric Axon Diameter Distribution mapping using PGSE and regularized discrete linear modeling

Jean-Philippe Thiran, Alessandro Daducci, David Paul Roger Romascano, Muhamed Barakovic, Anna Auria Rasclosa

Axon Diameter Distributions (ADDs) change during brain development and are altered in several brain pathologies. Mapping ADDs non-invasively using dMRI could provide a useful biomarker, but existing methods are either parametric, orientation dependent, sur ...

2017

Assessing feasibility and reproducibility of a bundle-specific framework on in vivo axon diameter estimates at 300mT/m

Jean-Philippe Thiran, Alessandro Daducci, Gabriel Girard, David Paul Roger Romascano, Maxime Descoteaux, Muhamed Barakovic, Jonathan Rafael Patino Lopez, Giorgio Innocenti

In vivo quantitative estimation of axon diameter in the white matter could bring new tools to study the structural and functional architecture of the brain. Recently, the feasibility of axon diameter estimation with diffusion-weighted MRI (DW-MRI) has been ...

2018

Multiple Sclerosis Lesion Fingerprint Using Multicontrast MRI

Jean-Philippe Thiran, Cristina Granziera, Gunnar Krüger, Djalel Eddine Meskaldji, Gloria Menegaz, David Paul Roger Romascano, Alexis Roche, Guillaume Bonnier, Ying-Chia Lin

Conventional magnetic resonance imaging (MRI) measures of multiple sclerosis patients provide limited information about the nature and the extent of brain damage and repair. We established a clinically compatible protocol including quantitative MRI techniq ...

2014

On evaluating the accuracy and biological plausibility of diffusion MRI tractograms

Jean-Philippe Thiran, Alessandro Daducci, David Paul Roger Romascano

One of the major limitations of diffusion MRI tractography is that the tractograms, i.e. set of fiber tracts, recovered by existing algorithms are not truly quantitative. Hence, the structural connectivity between different brain regions, a.k.a. connectomi ...

2015

Tractostorm: The what, why, and how of tractography dissection reproducibility

Alessandro Daducci, Gabriel Girard, David Paul Roger Romascano, Maxime Descoteaux, Muhamed Barakovic

Investigative studies of white matter (WM) brain structures using diffusion MRI (dMRI) tractography frequently require manual WM bundle segmentation, often called "virtual dissection." Human errors and personal decisions make these manual segmentations har ...

Wiley2020

Successful MRI-Guided Focused Ultrasound Thalamotomy after Ipsilateral Gamma Knife Radiosurgery for Essential Tremor: A Case Report with Video

Constantin Tuleasca, David Paul Roger Romascano

We report the case of a 67-year-old left-handed female patient with disabling medically refractory essential tremor who underwent successful right-sided magnetic resonance-guided focused ultrasound (MRgFUS) of the ventral intermediate nucleus after ipsilat ...

Karger2023

Reducing acquisition time for microstructure imaging with spatially-regularized global optimization

Jean-Philippe Thiran, Alessandro Daducci, Yves Wiaux, Erick Jorge Canales Rodriguez, David Paul Roger Romascano, Anna Auria Rasclosa

Microstructure imaging with diffusion MRI (dMRI) is usually based on fitting models to the data using voxelwise nonlinear procedures that (i) are time consuming and (ii) need long acquisitions. Recently, we introduced the AMICO framework to accelerate the ...

2016

Multicontrats MRI Improved the Clinico-Radiological Correlation in Early Multiple Sclerosis Patients with Minor Deficits

Jean-Philippe Thiran, Cristina Granziera, Gunnar Krüger, Djalel Eddine Meskaldji, Gloria Menegaz, David Paul Roger Romascano, Alexis Roche, Guillaume Bonnier, Ying-Chia Lin

Conventional magnetic resonance imaging (MRI) of patients with multiple sclerosis provides only limited insights into the nature of brain tissue damage with modest clinical-radiological correlations. In this study, quantitative and semi-quantitative MRI te ...

2014

Reducing acquisition time for axon diameter mapping using global optimization in the spatial-angular-microstructure space

Jean-Philippe Thiran, Alessandro Daducci, Yves Wiaux, Erick Jorge Canales Rodriguez, David Paul Roger Romascano, Anna Auria Rasclosa

State-of-the-art microstructure imaging methods usually fit biophysical models to the diffusion MRI data on a voxel-by-voxel basis using non-linear procedures that require both long acquisitions and processing time. We recently introduced AMICO, a framewor ...

2016

When does a volume of a bundle achieve saturation? A microstructure informed tractography study

Jean-Philippe Thiran, Alessandro Daducci, Gabriel Girard, David Paul Roger Romascano, Muhamed Barakovic, Maxime Descoteaux

Volumetric analysis of bundles derived from tractography is a popular statistical measure used in neurological disorder studies. Recent research performed by Gauvin shows that different bundles saturate with different tractography parameters, however, to a ...

2017