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Christian Hartinger

Cette personne a quitté l’EPFL

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Publications associées (53)

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Influence of the Arene Ligand, the Number and Type of Metal Centers, and the Leaving Group on the in Vitro Antitumor Activity of Polynuclear Organometallic Compounds

Kay Severin, Alexey Nazarov, Christian Hartinger

Dinuclear ruthenium complexes were shown to exhibit strong antiproliferative properties in human tumor cell lines. In order to extend the structure−activity relationships (SARs), a series of new RuII(arene)X complexes (X = Cl, Br, I) linked by pyridinone-b ...

2009

The Hydration of Chloroacetonitriles Catalyzed by Mono- and Dinuclear Ru-II- and Os-II-Arene Complexes

Christian Hartinger, Alexey Nazarov

The hydration of nitrites to the corresponding amides is all important reaction for both laboratory and industry purposes. The classical synthesis method requires harsh conditions, gives low yields, and is nonselective due to further hydrolysis of the amid ...

2008

The development of RAPTA compounds for the treatment of tumors

Paul Joseph Dyson, Christian Hartinger, Benjamin Samuel Murray

Ruthenium(II)-arene RAPTA-type compounds have been extensively explored for their medicinal properties. Herein a comprehensive review of this class of compounds is provided. A discussion of the basic RAPTA structure is given together with the ways it has b ...

Elsevier Science Sa2016

Phosphite-derivatized ruthenium-carbohydrate complexes in the catalytic hydration of nitriles

Christian Hartinger, Alexey Nazarov

The synthesis of metal complexes with bioligands is one option to introduce chirally defined ligands to catalysts. Herein, file hydration of nitriles to the corresponding carboxamides by use of ruthenium(H) complexes is described, which were obtained by at ...

2008

Design of ruthenium-based small molecules as potential therapeutic agents

Paul Joseph Dyson, Christian Hartinger, Alexey Nazarov

This presentation will focus on research carried out in our labs. on organometallic compds. based on the ruthenium(II)-arene unit that exhibit promising in vitro and in vivo anticancer activity and potentially overcome the limitations of platinum based ant ...

2009

From Pyrone to Thiopyrone Ligands-Rendering Maltol-Derived Ruthenium(II)-Arene Complexes That Are Anticancer Active in Vitro

Christian Hartinger, Alexey Nazarov

Ru(II)-arene complexes with pyrone-derived ligands are rendered active against cancer cells by replacement of the coordinated O,O donor with an S,O donor. The different stabilities of these systems may explain the observed influence of the donor atoms on t ...

2009

Stability of an organometallic ruthenium-ubiquitin adduct in the presence of glutathione: Relevance to antitumor activity

Paul Joseph Dyson, Yury Tsybin, Christian Hartinger, Angela Casini

The interactions of the ruthenium(II) complex Ru(η6-p-cymene)(pta)Cl2 (RAPTA-C), an effective anticancer and antimetastatic agent, with biol. nucleophiles are important with respect to its mechanism of action, for example, the reaction with glutathione (GS ...

2008

Hydrolysis study of the bifunctional antitumor compound RAPTA-C, [Ru(η6-p-cymene)Cl2(pta)]

Paul Joseph Dyson, Christian Hartinger, Claire Samantha Allardyce, Claudine Scolaro

The hydrolysis of [Ru(η6-p-cymene)Cl2(PTA)] (PTA = 1,3,5-triaza-7-phosphatricyclo-[3.3.1.1]decanephosphine; RAPTA-C) was studied using UV-visible (UV-vis) spectrophotometry and NMR spectroscopy. In analogy to in silico studies, [Ru(η6-p-cymene)Cl(H2O)(PTA) ...

2008

Elucidation of the interactions of an anticancer ruthenium complex in clinical trials with biomolecules utilizing capillary electrophoresis hyphenated to inductively coupled plasma-mass spectrometry

Paul Joseph Dyson, Christian Hartinger, Michael Groessl

The application of capillary electrophoresis (CE) combined with highly sensitive inductively-coupled-plasma mass spectrometric (ICP-MS) detection allows the interactions of metal complexes with biomols. to be characterized. This technique has been used to ...

2008

Royal Society of Chemistry2012

Modifying the Structure of Dinuclear Ruthenium Complexes with Antitumor Activity

Kay Severin, Alexey Nazarov, Christian Hartinger

2008

Christian Hartinger

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Influence of the Arene Ligand, the Number and Type of Metal Centers, and the Leaving Group on the in Vitro Antitumor Activity of Polynuclear Organometallic Compounds

The Hydration of Chloroacetonitriles Catalyzed by Mono- and Dinuclear Ru-II- and Os-II-Arene Complexes

The development of RAPTA compounds for the treatment of tumors

Phosphite-derivatized ruthenium-carbohydrate complexes in the catalytic hydration of nitriles

Design of ruthenium-based small molecules as potential therapeutic agents

From Pyrone to Thiopyrone Ligands-Rendering Maltol-Derived Ruthenium(II)-Arene Complexes That Are Anticancer Active in Vitro

Stability of an organometallic ruthenium-ubiquitin adduct in the presence of glutathione: Relevance to antitumor activity

Hydrolysis study of the bifunctional antitumor compound RAPTA-C, [Ru(η6-p-cymene)Cl2(pta)]

Elucidation of the interactions of an anticancer ruthenium complex in clinical trials with biomolecules utilizing capillary electrophoresis hyphenated to inductively coupled plasma-mass spectrometry

A Ruthenium Antimetastasis Agent Forms Specific Histone Protein Adducts in the Nucleosome Core

Influence of the Spacer Length on the in Vitro Activity of Dinuclear Ruthenium-Arene Compounds

Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules

Modifying the Structure of Dinuclear Ruthenium Complexes with Antitumor Activity