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Sean Lewis Hill

Cette personne a quitté l’EPFL

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Publications associées (41)

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Agile text mining with Sherlok

Jean-Cédric Chappelier, Sean Lewis Hill, Renaud Luc Richardet

The successful development of an intelligent text mining application requires the collaboration of two main stakeholders: subject matter experts and text miners. In this paper, we describe a new methodology, agile text mining to improve that collaboration. ...

IEEE2015

Computational Neuroscience Ontology: a new tool to provide semantic meaning to your models

Sean Lewis Hill

The diversity of modeling approaches in computational neuroscience makes model sharing, retrieval, reuse and reproducibility difficult and even sometimes impossible. To address this problem, standardized languages have been developed by and for the communi ...

2012

Reconstruction and simulation of neocortical microcircuitry

Henry Markram, Felix Schürmann, Sean Lewis Hill, Eilif Benjamin Muller

Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for reconstructing and simulating neocortical microcircuitry. In one aspect, a method includes providing a model of neural tissue, the model including differ ...

2018

GABA-mediated tonic inhibition differentially modulates gain in functional subtypes of cortical interneurons

Sean Lewis Hill, Christian Andreas Rössert, Bas-Jan Zandt

The binding of GABA (gamma-aminobutyric acid) to extrasynaptic GABA(A) receptors generates tonic inhibition that acts as a powerful modulator of cortical network activity. Despite GABA being present throughout the extracellular space of the brain, previous ...

National Academy of Sciences2020

Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI)

Sean Lewis Hill

BACKGROUND: Current classification of traumatic brain injury (TBI) is suboptimal, and management is based on weak evidence, with little attempt to personalize treatment. A need exists for new precision medicine and stratified management approaches that inc ...

Lippincott, Williams & Wilkins2015

The Resource Identification Initiative: A cultural shift in publishing

Sean Lewis Hill

A central tenet in support of research reproducibility is the ability to uniquely identify research resources, i.e., reagents, tools, and materials that are used to perform experiments. However, current reporting practices for research resources are insuff ...

Wiley-Blackwell2016

Data Publications Correlate with Citation Impact

Sean Lewis Hill

Neuroscience and molecular biology have been generating large datasets over the past years that are reshaping how research is being conducted. In their wake, open data sharing has been singled out as a major challenge for the future of research. We conduct ...

Frontiers Research Foundation2016

Feeding the human brain model

Sean Lewis Hill

The goal of the Human Brain Project is to develop, during the next decade, an infrastructure capable of simulating a draft human brain model based on available experimental data. One of the key issues is therefore to integrate and make accessible the exper ...

Elsevier2015

Models of neocortical layer 5b pyramidal cells capturing a wide range of dendritic and perisomatic active properties

Henry Markram, Felix Schürmann, Sean Lewis Hill, Idan Segev

The thick-tufted layer 5b pyramidal cell extends its dendritic tree to all six layers of the mammalian neocortex and serves as a major building block for the cortical column. L5b pyramidal cells have been the subject of extensive experimental and modeling ...

2011

A neuron membrane mesh representation for visualization of electrophysiological simulations

Henry Markram, Felix Schürmann, Sean Lewis Hill, Juan Bautista Hernando Vieites, Sébastien Lasserre

We present a process to automatically generate three-dimensional mesh representations of the complex, arborized cell membrane surface of cortical neurons (the principal information processing cells of the brain) from nonuniform morphological measurements. ...

Institute of Electrical and Electronics Engineers2012

Grand Challenges for Global Brain Sciences

Sean Lewis Hill, Miguel Nicolelis, Corrado Cali

The next grand challenges for society and science are in the brain sciences. A collection of 60+ scientists from around the world, together with 10+ observers from national, private, and foundations, spent two days together discussing the top challenges th ...

2016

A Hierarchical Structure of Cortical Interneuron Electrical Diversity Revealed by Automated Statistical Analysis

Henry Markram, Felix Schürmann, Sean Lewis Hill, Idan Segev

Although the diversity of cortical interneuron electrical properties is well recognized, the number of distinct electrical types (e-types) is still a matter of debate. Recently, descriptions of interneuron variability were standardized by multiple laborato ...

Oxford University Press2013

Automatic target validation based on neuroscientific literature mining for tractography

Jean-Cédric Chappelier, Jocelyne Bloch, Sean Lewis Hill, Renaud Luc Richardet

Target identification for tractography studies requires solid anatomical knowledge validated by an extensive literature review across species for each seed structure to be studied. Manual literature review to identify targets for a given seed region is ted ...

Frontiers Research Foundation2015

Reconstructing the brain: from image stacks to neuron synthesis

Sean Lewis Hill, Julian Charles Shillcock

Large-scale brain initiatives such as the US BRAIN initiative and the European Human Brain Project aim to marshall a vast amount of data and tools for the purpose of furthering our understanding of brains. Fundamental to this goal is that neuronal morpholo ...

2016

How do we know what we know? Discovering neuroscience data sets through minimal metadata

Sean Lewis Hill

With the emergence of brain research initiatives around the world, the need for standards to facilitate neuroscience data sharing is growing. A crucial first step will be to establish a minimal metadata standard that allows the discovery of and access to s ...

2016

Structural to functional synaptic conversion

Henry Markram, Felix Schürmann, Sean Lewis Hill, Eilif Benjamin Muller, Michael Reimann, James Gonzalo King

Computer-implemented methods, software, and systems for determining functional synapses from given structural touches between cells in a neuronal circuit are described. One computer-implemented method for determining functional synapses from predetermined ...

Technology Transfer Office EPFL2015

Breakdown of Effective Connectivity During Slow Wave Sleep: Investigating the Mechanism Underlying a Cortical Gate Using Large-Scale Modeling

Sean Lewis Hill

Esser SK, Hill S, Tononi G. Breakdown of effective connectivity during slow wave sleep: investigating the mechanism underlying a cortical gate using large-scale modeling. J Neurophysiol 102: 2096-2111, 2009. First published August 5, 2009; doi: 10.1152/jn. ...

2009

Evaluating automated parameter constraining procedures of neuron models by experimental and surrogate data

Henry Markram, Felix Schürmann, Sean Lewis Hill, Idan Segev

Neuron models, in particular conductance-based compartmental models, often have numerous parameters that cannot be directly determined experimentally and must be constrained by an optimization procedure. A common practice in evaluating the utility of such ...

2008

Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research

Sean Lewis Hill, William John Stewart

Elsevier2017

Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep

Henry Markram, Sean Lewis Hill, Rodrigo de Campos Perin, Michael Reimann, Marwan Muhammad Ahmed Abdellah, Werner Alfons Hilda Van Geit, Matthias Wolf, James Gonzalo King, Ying Shi, András Ecker, Rajnish Ranjan, Jean-Denis Georges Emile Courcol, Pramod Shivaji Kumbhar, Christian O'Reilly, Michael Emiel Gevaert, Fernando Joaquim Leite Pereira, Mustafa Anil Tuncel, Nadir Roman Guerrero, Elisabetta Iavarone, Mohameth François Sy, Benoît Jean-Albert Coste, Ioannis Magkanaris, Cyrille Pierre Henri Favreau, Genrich Ivaska, Anna-Kristin Kaufmann, Joni Henrikki Herttuainen, Grigori Chevtchenko, Samuel Claude Kerrien, Jayakrishnan Harikrishnavilas Raveendran Nair, Adrien Christian Fleury, Marine Laure Bertschy, Fabien Petitjean, Liviu Soltuzu, Alexander Désiré Ulbrich, Polina Litvak, Vignayanandam Ravindernath Muddapu, Patrycja Lurie

2023