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Françoise Gisou van der Goot Grunberg

Cette personne a quitté l’EPFL

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Publications associées (76)

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Pathogenic Pore-Forming Proteins: Function and Host Response

Françoise Gisou van der Goot Grunberg, Mircea Ioan Iacovache, Mirko Bischofberger

Organisms from all kingdoms produce pore-forming proteins, with the best-characterized being of bacterial origin. The last decade of research has revealed that the channels formed by these proteins can be very diverse, thus differentially affecting target ...

Cell Press2012

Calnexin Controls the STAT3-Mediated Transcriptional Response to EGF

Françoise Gisou van der Goot Grunberg

Calnexin is a well-characterized transnnembrane chaperone involved in the folding of newly synthesized glycoproteins in the lumen of the endoplasmic reticulum (ER). Here, we reveal a previously unrecognized function of calnexin in regulating the transcript ...

Elsevier2013

S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity

Didier Trono, Matteo Dal Peraro, Françoise Gisou van der Goot Grunberg, Priscilla Turelli, Luciano Andres Abriata, Laurence Gouzi Abrami, Giovanni D'Angelo, Charlène Mireille Raymonde Raclot, Béatrice Kunz, Francisco De Magalhães Sarmento Ribeiro De Mesquita, Oksana Andrei Sergeeva

SARS-CoV-2 virions are surrounded by a lipid bilayer that contains membrane proteins such as spike, responsible for target-cell binding and virus fusion. We found that during SARS-CoV-2 infection, spike becomes lipid modified, through the sequential action ...

Cell Press - Elsevier2021

The dark sides of capillary morphogenesis gene 2

Françoise Gisou van der Goot Grunberg, Julie Deuquet Ariosa

Capillary morphogenesis gene 2 (CMG2) is a type I membrane protein involved in the homeostasis of the extracellular matrix. While it shares interesting similarities with integrins, its exact molecular role is unknown. The interest and knowledge about CMG2 ...

2012

Injury-induced intestinal stem cell renewal requires capillary morphogenesis gene 2

Françoise Gisou van der Goot Grunberg, Nathalie Brandenberg, Olivier Burri, Romain Guiet, Julien Léonard Duc, Béatrice Kunz, Lucie Josepha Marie Bracq, Audrey Geneviève Chuat

Patients with the rare genetic disorder Hyaline Fibromatosis Syndrome (HFS) often succumb before 18 months of age due to severe diarrhea. As HFS is caused by loss-of-function mutations in the gene encoding capillary morphogenesis gene 2 (CMG2), these sympt ...

Springer Science and Business Media LLC2025

Live-cell multiplane three-dimensional super-resolution optical fluctuation imaging

Theo Lasser, Françoise Gisou van der Goot Grunberg, Marcel Leutenegger, Noelia Laura Bocchio, Aurélien Godinat, Patrick Alain Sandoz, Azat Sharipov

Super-resolution optical fluctuation imaging (SOFI) provides an elegant way of overcoming the diffraction limit in all three spatial dimensions by computing higher-order cumulants of image sequences of blinking fluorophores acquired with a classical widefi ...

Nature Research2014

About lipids and toxins

Françoise Gisou van der Goot Grunberg

Many mono or multicellular organisms secrete soluble proteins, referred to as protein toxins, which alter the behavior of foreign, or target cells, possibly leading to their death. These toxins affect either the cell membrane by forming pores or modifying ...

2006

Pore formation: an ancient yet complex form of attack

Françoise Gisou van der Goot Grunberg, Mircea Ioan Iacovache

Bacteria, as well as higher organisms such as sea anemones or earthworms, have developed sophisticated virulence factors such as the pore-forming toxins (PFTs) to mount their attack against the host. One of the most fascinating aspects of PFTs is that they ...

2008

Close Encounter of the Third Kind: The ER Meets Endosomes at Fission Sites

Françoise Gisou van der Goot Grunberg

The endoplasmic reticulum (ER) forms functional contacts with several cellular organelles and regulates processes such as mitochondrial fission. In a recent issue of Cell, Rowland et al. (2014) extend these findings to endosomes, showing that the ER contac ...

Cell Press - Elsevier2014

Molecular assembly of the aerolysin pore reveals a swirling membrane-insertion mechanism

Matteo Dal Peraro, Françoise Gisou van der Goot Grunberg, Henning Paul-Julius Stahlberg, Matteo Thomas Degiacomi, Mircea Ioan Iacovache

Aerolysin is the founding member of a superfamily of (beta-pore-forming toxins whose pore structure is unknown. We have combined X-ray crystallography, cryo-EM, molecular dynamics and computational modeling to determine the structures of aerolysin mutants ...

Nature Publishing Group2013

Hemagglutinin of Influenza A, but not of Influenza B and C viruses is acylated by ZDHHC2, 8, 15 and 20

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami

Hemagglutinin (HA), a glycoprotein of Influenza A viruses and its proton channel M2 are site-specifically modified with fatty acids. Whereas two cysteines in the short cytoplasmic tail of HA contain only palmitate, stearate is exclusively attached to one c ...

PORTLAND PRESS LTD2020

Refining S-acylation: Structure, regulation, dynamics, and therapeutic implications

Françoise Gisou van der Goot Grunberg, Muhammad Umair Anwar

S-acylation is one of the most frequent posttranslational modifications that regulates diverse cellular processes. Anwar and van der Goot discuss the complexity and disease implications of this highly regulated reversible lipidation. ...

Rockefeller University Press2023

Damage of eukaryotic cells by the pore-forming toxin sticholysin II: Consequences of the potassium efflux

Françoise Gisou van der Goot Grunberg, Sylvia Ho

Pore-forming toxins (PFTs) form holes in membranes causing one of the most catastrophic damages to a target cell. Target organisms have evolved a regulated response against PFTs damage including cell membrane repair. This ability of cells strongly depends ...

Elsevier Science Bv2017

Mechanisms of pathogen entry through the endosomal compartments

Françoise Gisou van der Goot Grunberg

Several pathogens - bacteria, viruses and parasites - must enter mammalian cells for survival, replication and immune-system evasion. These pathogens generally make use of existing cellular pathways that are designed for nutrient uptake, receptor downregul ...

2006

Revealing Assembly of a Pore-Forming Complex Using Single-Cell Kinetic Analysis and Modeling

Françoise Gisou van der Goot Grunberg, Felix Naef, Daniel Boss, Mircea Ioan Iacovache, Mirko Bischofberger

Many biological processes depend on the sequential assembly of protein complexes. However, studying the kinetics of such processes by direct methods is often not feasible. As an important class of such protein complexes, pore-forming toxins start their jou ...

Elsevier2016

Pore-forming toxins: ancient, but never really out of fashion

Françoise Gisou van der Goot Grunberg, Matteo Dal Peraro

Pore-forming toxins (PFTs) are virulence factors produced by many pathogenic bacteria and have long fascinated structural biologists, microbiologists and immunologists. Interestingly, pore-forming proteins with remarkably similar structures to PFTs are fou ...

Nature Publishing Group2016

Intra-endosomal membrane traffic

Françoise Gisou van der Goot Grunberg

Following endocytosis, ubiquitinated signaling receptors are incorporated within intraluminal vesicles of forming multivesicular endosomes. These vesicles then follow the pathway from early to late endosomes, remaining within the endosomal lumen, and are e ...

2006

Palmitoylation, pathogens and their host

Françoise Gisou van der Goot Grunberg, Sanja Blaskovic, Mathieu Blanc

S-Palmitoylation, the only reversible post-translational lipid modification, confers unique biochemical and functional properties to proteins. Although it has long been known that viral proteins are palmitoylated, recent studies reveal that this modificati ...

2013

Harnessing the Membrane Translocation Properties of AB Toxins for Therapeutic Applications

Numa Piot, Françoise Gisou van der Goot Grunberg, Oksana Andrei Sergeeva

Over the last few decades, proteins and peptides have become increasingly more common as FDA-approved drugs, despite their inefficient delivery due to their inability to cross the plasma membrane. In this context, bacterial two-component systems, termed AB ...

2021

Did Cholera Toxin Finally Get Caught?

Françoise Gisou van der Goot Grunberg

To orchestrate immune responses, pathogen-recognition receptors have evolved sophisticated strategies to monitor pathogenic processes. In this issue of Cell Host & Microbe, a study by Cho et al. reveals a mechanism of immune recognition that relies on the ...

Cell Press2013