Publications de Felix Schürmann

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With a computational model of energy metabolism in an astrocyte, we show how a system of enzymes in a cascade can act as a functional unit of interdependent reactions, rather than merely a series of independent reactions. These systems may exist in multipl ...

We explored a computational model of astrocytic energy metabolism and demonstrated the theoretical plausibility that this type of pathway might be capable of coding information about stimuli in addition to its known functions in cellular energy and carbon ...

Simulations of electrical activity of networks of morphologically detailed neuron models allow for a better understanding of the brain. State-of-the-art simulations describe the dynamics of ionic currents and biochemical processes within branching topologi ...

Cortical dynamics underlie many cognitive processes and emerge from complex multi-scale interactions, which are challenging to study in vivo. Large-scale, biophysically detailed models offer a tool which can complement laboratory approaches. We present a m ...

In realistic neuronal modeling, once the ionic channel complement has been defined, the maximum ionic conductance (Gi-max) values need to be tuned in order to match the firing pattern revealed by electrophysiological recordings. Recently, selection/mutatio ...

The acquisition of high quality maps of gene expression in the rodent brain is of fundamental importance to the neuroscience community. The generation of such datasets relies on registering individual gene expression images to a reference volume, a task en ...

Computational modeling and simulation have become essential tools in the quest to better understand the brain's makeup and to decipher the causal interrelations of its components. The breadth of biochemical and biophysical processes and structures in the b ...

The electrical diversity of neurons arises from the expression of different combinations of ion channels. The gene expression rules governing these combinations are not known. We examined the expression of twenty-six ion channel genes in a broad range of s ...

It is well-established that synapse formation involves highly selective chemospecific mechanisms, but how neuron arbors are positioned before synapse formation remains unclear. Using 3D reconstructions of 298 neocortical cells of different types (including ...

Big science initiatives are trying to reconstruct and model the brain by attempting to simulate brain tissue at larger scales and with increasingly more biological detail than previously thought possible. The exponential growth of parallel computer perform ...

It has previously been shown that it is possible to derive a new class of biophysically detailed brain tissue models when one computationally analyzes and exploits the interdependencies or the multi-modal and multi-scale organization of the brain. These re ...

The rich dynamical nature of neurons poses major conceptual and technical challenges for unraveling their nonlinear membrane properties. Traditionally, various current waveforms have been injected at the soma to probe neuron dynamics, but the rationale for ...

Exposing parallelism in scientific applications has become a core requirement for efficiently running on modern distributed multicore SIMD compute architectures. The granularity of parallelism that can be attained is a key determinant for the achievable ac ...

Motivation: Accurate morphological models of brain vasculature are key to modeling and simulating cerebral blood flow in realistic vascular networks. This in silico approach is fundamental to revealing the principles of neurovascular coupling. Validating t ...

Digital brain atlases define a hierarchy of brain regions and their locations in three-dimensional space. They provide a standard coordinate system in which diverse datasets can be integrated for visualization and analysis. They also enable building of dat ...

Many neurodegenerative diseases are associated with the death of specific neuron types in particular brain regions. What makes the death of specific neuron types particularly harmful for the integrity and dynamics of the respective network is not well unde ...

Neurons are characterized by thin and long interleaving arborizations in which creating accurate mesh models of their cellular membranes is challenging. While union operators are central for CAD/CAM modeling and computer graphics applications, their applic ...

To build biophysically detailed models of brain cells, circuits, and regions, a data-driven approach is increasingly being adopted. This helps to obtain a simulated activity that reproduces the experimentally recorded neural dynamics as faithfully as possi ...

Advances in computational capabilities and large volumes of experimental data have established computer simulations of brain tissue models as an important pillar in modern neuroscience. Alongside, a variety of domain specific languages (DSLs) have been dev ...

Throughout the nervous system, cells belonging to a certain electrical class (e-class)-sharing high similarity in firing response properties-may nevertheless have widely variable dendritic morphologies. To quantify the effect of this morphological variabil ...

Felix Schürmann

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Excitation states of metabolic networks predict dose-response fingerprinting and ligand pulse phase signalling

Representing stimulus information in an energy metabolism pathway

Asynchronous Branch-Paralle Simulation of Detailed Neuron Models

Modeling and simulation of neocortical micro- and mesocircuitry. Part II: Physiology and experimentation

Single Neuron Optimization as a Basis for Accurate Biophysical Modeling : The Case of Cerebellar Granule Cells

Supervised Learning With Perceptual Similarity for Multimodal Gene Expression Registration of a Mouse Brain Atlas

Understanding Computational Costs of Cellular-Level Brain Tissue Simulations Through Analytical Performance Models

Combinatorial expression rules of ion channel genes in juvenile rat (Rattus norvegicus) neocortical neurons

Statistical connectivity provides a sufficient foundation for specific functional connectivity in neocortical neural microcircuits

Analytic performance modeling and analysis of detailed neuron simulations

Computational Concepts for Reconstructing and Simulating Brain Tissue

Effective Stimuli for Constructing Reliable Neuron Models

Exploiting Flow Graph of System of ODEs to Accelerate the Simulation of Biologically-Detailed Neural Networks

Interactive visualization and analysis of morphological skeletons of brain vasculature networks with VessMorphoVis

Enhancement of brain atlases with region-specific coordinate systems: flatmaps and barrel column annotations

The Role of Hub Neurons in Modulating Cortical Dynamics

Meshing of Spiny Neuronal Morphologies using Union Operators

Online interoperable resources for building hippocampal neuron models via the Hippocampus Hub

MOD2IR: High-Performance Code Generation for a Biophysically Detailed Neuronal Simulation DSL

Preserving axosomatic spiking features despite diverse dendritic morphology