Jean-Marie Petit

Cette personne n’est plus à l’EPFL

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Publications associées (26)

Role of the Glyoxalase System in Astrocyte-Mediated Neuroprotection

Pierre Magistretti, Igor Allaman, Jean-Marie Petit, Thierry Laroche, Jiangyan Yang

The glyoxalase system is the most important pathway for the detoxification of methylglyoxal (MG), a highly reactive dicarbonyl compound mainly formed as a by-product of glycolysis. MG is a major precursor of advanced glycation end products (AGEs), which ar ...

2011

Metabolic response of the cerebral cortex following gentle sleep deprivation and modafinil administration

Pierre Magistretti, Jean-Marie Petit, Christophe Kopp

Objectives: The main energy reserve of the brain is glycogen, which is almost exclusively localized in astrocytes. We previously reported that cerebral expression of certain genes related to glycogen metabolism changed following instrumental sleep deprivat ...

2010

Alteration of brain glycogen turnover in the conscious rat after 5h of prolonged wakefulness

Pierre Magistretti, Bernard Lanz, Rolf Gruetter, Jean-Marie Petit, Hanne Frenkel

Although glycogen (Glyc) is the main carbohydrate storage component, the role of Glyc in the brain during prolonged wakefulness is not clear. The aim of this study was to determine brain Glyc concentration ([]) and turnover time (tau) in euglycemic conscio ...

Elsevier2009

Alteration of brain glycogen turnover in the awake rat

Pierre Magistretti, Bernard Lanz, Rolf Gruetter, Jean-Marie Petit, Hanne Frenkel

Nature Publishing Group2009

Expression of genes related to brain energy metabolism following pharmacological and instrumental short sleep deprivation

Sylvain Eric Lengacher, Pierre Magistretti, Jean-Marie Petit, Sophie Burlet Godinot

2008

Chloramphenicol decreases brain glucose utilization and modifies the sleep-wake cycle architecture in rats

Pierre Magistretti, Jean-Marie Petit

We studied the effects of chloramphenicol on brain glucose utilization and sleep-wake cycles in rat. After slightly anaesthetized animals were injected with [18F]fluoro-2-deoxy-D-glucose, we acquired time-concentration curves from three radiosensitive beta ...

Wiley-Blackwell2005

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