Rafaela Fernandes Da Silva

Cette personne n’est plus à l’EPFL

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Publications associées (32)

Cardiovascular effects of arginase inhibition in spontaneously hypertensive rats with fully developed hypertension

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva

Growing evidence suggests that arginase misregulation plays a key role in the pathophysiology of essential hypertension. In the present study, we investigated the potential cardiovascular therapeutic effects of a long-term treatment with an arginase inhibi ...

Oxford University Press2010

Autonomous effects of shear stress and cyclic circumferential stretch regarding endothelial dysfunction and oxidative stress: an ex vivo arterial model

Nikolaos Stergiopoulos, Paolo Silacci, Tyler Nerton Thacher, Rafaela Fernandes Da Silva

Cyclic circumferential stretch and shear stress caused by pulsatile blood flow work in concert, yet are very different stimuli capable of independently mediating endothelial function by modulating eNOS expression, oxidative stress (via production of supero ...

American Soc Mechanical Engineers, Three Park Avenue, New York, Ny 10016-5990 Usa2009

Differential effects of reduced cyclic stretch and perturbed shear stress within the arterial wall and on smooth muscle function

Nikolaos Stergiopoulos, Tyler Nerton Thacher, Rafaela Fernandes Da Silva

Cyclic circumferential stretch and shear stress act in concert and yet are capable of independently mediating arterial smooth muscle function, modulating the production of superoxide and stimulating arterial remodeling. ...

Oxford University Press2009

Reduced cyclic stretch, endothelial dysfunction, and oxidative stress: an ex vivo model

Nikolaos Stergiopoulos, Veronica Gambillara, Paolo Silacci, Tyler Nerton Thacher, Rafaela Fernandes Da Silva

The objective of this study was to investigate whether reduction of cyclic circumferential stretch will impair endothelial function and elevate basal levels of oxidative stress, both known risk factors linked to cardiovascular disease. ...

2009

Regulation of arginase pathway in response to wall shear stress

Nikolaos Stergiopoulos, Veronica Gambillara, Paolo Silacci, Fabienne Riche, Tyler Nerton Thacher, Rafaela Fernandes Da Silva

Alterations of wall shear stress can predispose the endothelium to the development of atherosclerotic plaques. Ample evidence indicates that arginase expression and/or activity correlates with several risk factors for cardiovascular disease including ather ...

2009

Effects Of Reduced Compliance On Endothelial Functionality With Regards To Inflammation

Nikolaos Stergiopoulos, Veronica Gambillara, Paolo Silacci, Tyler Nerton Thacher, Rafaela Fernandes Da Silva

American Soc Mechanical Engineers, Three Park Avenue, New York, Ny 10016-5990 Usa2009

Transcriptional and post-transcriptional regulation of endothelin-1 gene by shear stress

Nikolaos Stergiopoulos, Paolo Silacci, Rafaela Fernandes Da Silva

Objective Plaque-prone areas are exposed to a particular hemodynamic environment characterized by a low mean shear stress value and a cyclic reversal flow. This mechanical environment, also termed oscillatory shear stress (OSS), induces the expression of s ...

2008

Effects of an aging vascular model on healthy and diseased hearts

Nikolaos Stergiopoulos, David Jegger, Patrick Segers, Rafaela Fernandes Da Silva

The vitamin D(3) and nicotine (VDN) model is a model of isolated systolic hypertension (ISH) due to arterial calcification raising arterial stiffness and vascular impedance similar to an aged and stiffened arterial tree. We therefore analyzed the impact of ...

2007

Oscillatory shear stress and reduced compliance impair vascular functions

Nikolaos Stergiopoulos, Veronica Gambillara, Paolo Silacci, Tyler Nerton Thacher, Rafaela Fernandes Da Silva

Shear stress has been shown to influence endothelial cell gene expression and morphology. In particular, low and bi-directional shear stress, mimicking conditions at plaque-prone areas, down-regulates the expression of several atheroprotective genes, and u ...

2007

Transcriptional and post-transcriptional regulation of preproendothelin-1 by plaque-prone hemodynamics

Nikolaos Stergiopoulos, Paolo Silacci, Rafaela Fernandes Da Silva

Plaque-prone areas are exposed to a particular hemodynamic environment characterized by a low mean shear stress value and a cyclic reversal flow. This mechanical environment, also termed oscillatory shear stress (OSS), induces the expression of several pro ...

2007

Role of arginase pathway in response to shear stress: new potential therapeutic targets for atherosclerosis?

Nikolaos Stergiopoulos, Veronica Gambillara, Rafaela Fernandes Da Silva

Introduction: Alterations of wall shear stress can predispose the endothelium to the development of atherosclerotic plaques. Ample evidence indicates that arginase expression and/or activity correlates with several risk factors for cardiovascular disease i ...

2007

The effect of a myocardial infarction on the normalized time-varying elastance curve

Nikolaos Stergiopoulos, David Jegger, Rafaela Fernandes Da Silva

It has been suggested that the shape of the normalized time-varying elastance curve [E(n)(t(n))] is conserved in different cardiac pathologies. We hypothesize, however, that the E(n)(t(n)) differs quantitatively after myocardial infarction (MI). Sprague-Da ...

2006

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