Karl Gademann

Cette personne a quitté l’EPFL

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Publications associées (49)

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The First Meeting for Young Chemistry Faculty, Organized by the "Platform Chemistry" of the Swiss Academy of Science (SCNAT)

Karl Gademann

2009

Bioinspired, releasable quorum sensing modulators

Karl Gademann

We demonstrate the synthesis and immobilization of natural product hybrids featuring an acyl-homoserine lactone and a nitrodopamine onto biocompatible TiO2 surfaces through an operationally simple dip-and-rinse procedure. The resulting immobilized hybrids ...

Royal Society of Chemistry2013

Balgacyclamides, Antiplasmodial Heterocyclic Peptides from Microcystis aeruguinosa EAWAG 251

Karl Gademann, Cyril Portmann, Emilie Baudat

The isolation and structural characterization of three new heterocyclic and macrocyclic peptides, balgacyclamides A C, from Microcystis aeruginosa EAWAG 251 are reported. The constitutions were determined by 2D-NMR methods and mass spectrometry, and the co ...

Amer Chemical Soc2014

Isolation and Structure Determination of Two Microcystins and Sequence Comparison of the McyABC Adenylation Domains in Planktothrix Species

Karl Gademann, Cyril Portmann

Microcystins (MCs) are toxic heptapeptides found in cyanobacteria and share the common structure cyclo(-D-Ala1-L- X2-D-isoMeAsp3-L-Z4-Adda5-D-isoGlu6-Mdha7). The letters X and Z in the general formula above represent a wide range of L-amino acids that occu ...

2008

Multiple Toxin Production in the Cyanobacterium Microcystis: Isolation of the Toxic Protease Inhibitor Cyanopeptolin 1020

Karl Gademann, Cyril Portmann

The isolation and structure of cyanopeptolin 1020 (hexanoic acid-Glu-N[-O-Thr-Arg-Ahp-Phe-N-Me-Tyr-Val-]) from a Microcystis strain is reported. Very potent picomolar trypsin inhibition (IC50 = 670 pM) and low nanomolar values against human kallikrein (4.5 ...

2010

Karl Gademann

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The First Meeting for Young Chemistry Faculty, Organized by the "Platform Chemistry" of the Swiss Academy of Science (SCNAT)

Bioinspired, releasable quorum sensing modulators

Balgacyclamides, Antiplasmodial Heterocyclic Peptides from Microcystis aeruguinosa EAWAG 251

Isolation and Structure Determination of Two Microcystins and Sequence Comparison of the McyABC Adenylation Domains in Planktothrix Species

Multiple Toxin Production in the Cyanobacterium Microcystis: Isolation of the Toxic Protease Inhibitor Cyanopeptolin 1020

Combining Devices and Drugs by Synthetic Natural Product Hybrids

Novel screening protocol for wet chemical surface functionalization

Chemistry Europe Fellows Katharina M. Fromm and Karl Gademann

Novel screening protocol for universal applicable adhesive molecules