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Didier Trono

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Publications associées (149)

S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity

Béatrice Kunz, Didier Trono, Priscilla Turelli, Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Matteo Dal Peraro, Charlène Mireille Raymonde Raclot, Luciano Andres Abriata, Oksana Andrei Sergeeva, Giovanni D'Angelo, Francisco De Magalhães Sarmento R De Mesquita

SARS-CoV-2 virions are surrounded by a lipid bilayer that contains membrane proteins such as spike, responsible for target-cell binding and virus fusion. We found that during SARS-CoV-2 infection, spike becomes lipid modified, through the sequential action ...

Cell Press - Elsevier2021

A high-throughput cell- and virus-free assay shows reduced neutralization of SARS-CoV-2 variants by COVID-19 convalescent plasma

Didier Trono, Priscilla Turelli, Florence Pojer, Charlène Mireille Raymonde Raclot, Céline Pellaton, Valeria Cagno, Jérémy Campos

The detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibodies in the serum of an individual indicates previous infection or vaccination. However, it provides limited insight into the protective nature of this immune resp ...

AMER ASSOC ADVANCEMENT SCIENCE2021

Large variation in anti-SARS-CoV-2 antibody prevalence among essential workers in Geneva, Switzerland

Didier Trono, Francisco Javier Perez Saez, Francesco Pennacchio, Maria Eugenia Zaballa, Idris Guessous

Limited data exist on SARS-CoV-2 infection rates across sectors and occupations, hindering our ability to make rational policy, including vaccination prioritization, to protect workers and limit SARS-CoV-2 spread. Here, we present results from our SEROCoV- ...

Nature Research2021

A highly potent antibody effective against SARS-CoV-2 variants of concern

Didier Trono, Priscilla Turelli, Davide Demurtas, Florence Pojer, Charlène Mireille Raymonde Raclot, Jérémy Campos, Kelvin Ka Ching Lau

Control of the ongoing SARS-CoV-2 pandemic is endangered by the emergence of viral variants with increased transmission efficiency, resistance to marketed therapeutic antibodies, and reduced sensitivity to vaccine-induced immunity. Here, we screen B cells ...

2021

KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage

Didier Trono, Alberto De Iaco

The Krüppel-associated box zinc finger protein (KRAB-ZFP) family diversified in mammals. The majority of human KRAB-ZFPs bind transposable elements (TEs), however, since most TEs are inactive in humans it is unclear whether KRAB-ZFPs emerged to suppress TE ...

2020

Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons

Didier Trono, Priscilla Turelli, Julien Léonard Duc, Bart Deplancke, Charlène Mireille Raymonde Raclot, Alexandre Coudray, Christian Axel Wandall Thorball, Julien Paul André Pontis, Evgeniia Pankevich, Delphine Yvette L Grun, Christopher James Playfoot

In the first days of embryogenesis, transposable element-embedded regulatory sequences (TEeRS) are silenced by Kruppel-associated box (KRAB) zinc finger proteins (KZFPs). Many TEeRS are subsequently co-opted in transcription networks, but how KZFPs influen ...

2020

Transpochimeric gene trancripts (tcgts) as cancer biomarkers

Didier Trono, Julien Léonard Duc, Evaristo Jose Planet Letschert, Laia Simo Riudalbas

The invention relates to methods for detecting or predicting the likelihood of a cancer in a subject as well as to compositions, pharmaceutical compositions and methods of treatment of cancer. ...

2020

KAP1 targets actively transcribed genomic loci to exert pleomorphic effects on RNA polymerase II activity

Didier Trono, Annamaria Kauzlaric, Marco Cassano, Suk Min Jang, Evaristo Jose Planet Letschert

KAP1 (KRAB-associated protein 1) is best known as a co-repressor responsible for inducing heterochromatin formation, notably at transposable elements. However, it has also been observed to bind the transcription start site of actively expressed genes. To a ...

2020

Endogenous retroviruses drive KRAB zinc-finger protein family expression for tumor suppression

Didier Trono, Priscilla Turelli, Alexandre Coudray

Gene expression aberration is a hallmark of cancers, but the mechanisms underlying such aberrations remain unclear. Human endogenous retroviruses (HERVs) are genomic repetitive elements that potentially function as enhancers. Since numerous HERVs are epige ...

AMER ASSOC ADVANCEMENT SCIENCE2020

The Human RNA Helicase DDX21 Presents a Dimerization Interface Necessary for Helicase Activity

Didier Trono, Annamaria Kauzlaric, Matteo Dal Peraro, Suliana Manley, Alice Duperrex, Maria Josefina Marcaida Lopez, Jenny Sülzle

Members of the DEAD-box helicase family are involved in all fundamental processes of RNA metabolism, and as such, their malfunction is associated with various diseases. Currently, whether and how oligomerization impacts their biochemical and biological fun ...

2020

Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Geneva, Switzerland (SEROCoV-POP): a population-based study

Didier Trono, Dusan Petrovic, Benjamin André René Meyer, David Nicolas De Ridder, Idris Guessous

Assessing the burden of COVID-19 on the basis of medically attended case numbers is suboptimal given its reliance on testing strategy, changing case definitions, and disease presentation. Population-based serosurveys measuring anti-severe acute respiratory ...

2020

Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes

Didier Trono, Marion Leleu, Evaristo Jose Planet Letschert, George Coukos, Ioannis Xenarios, Laia Simo Riudalbas, Delphine Yvette L Grun, Alexandre Harari, Markus Müller, Lin Zhang, Marion Arnaud, Florian Huber

Efforts to precisely identify tumor human leukocyte antigen (HLA) bound peptides capable of mediating T cell-based tumor rejection still face important challenges. Recent studies suggest that non-canonical tumor-specific HLA peptides derived from annotated ...

Nature Research2020

DPPA2 and DPPA4 are necessary to establish a 2C‐like state in mouse embryonic stem cells

Didier Trono, Julien Léonard Duc, Alexandre Coudray, Alberto De Iaco

After fertilization of the transcriptionally silent oocyte, expression from both parental chromosomes is launched through zygotic genome activation (ZGA), occurring in the mouse at the 2-cell (2C) stage. Among the first elements to be transcribed are the D ...

2019

Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs

Didier Trono, Priscilla Turelli, Julien Léonard Duc, Sandra Eloise Kjeldsen, Julien Duc, Alexandre Coudray, Evaristo Jose Planet Letschert, Julien Paul André Pontis

Expansion of transposable elements (TEs) coincides with evolutionary shifts in gene expression. TEs frequently harbor binding sites for transcriptional regulators, thus enabling coordinated genome-wide activation of species- and context-specific gene expre ...

2019

KAP1 is an antiparallel dimer with a functional asymmetry

Didier Trono, Davide Demurtas, Matteo Dal Peraro, Louise Catherine Bryan, Beat Fierz, Pierre-Yves Joseph Laurent Helleboid, Alexandra Styliani Kalantzi, Giulia Fonti, Maria Josefina Marcaida Lopez

KAP1 (KRAB domain-associated protein 1) plays a fundamental role in regulating gene expression in mammalian cells by recruiting different transcription factors and altering the chromatin state. In doing so, KAP1 acts both as a platform for macromolecular i ...

Life Science Alliance, LLC2019

ZNF445 is a primary regulator of genomic imprinting

Didier Trono, Priscilla Turelli, Sandra Eloise Kjeldsen, Michaël Imbeault, Andrea Coluccio, Evaristo Jose Planet Letschert, Christian Axel Wandall Thorball

Genomic imprinting is an epigenetic process regulated by germline-derived DNA methylation, causing parental origin-specific monoallelic gene expression. Zinc finger protein 57 (ZFP57) is critical for maintenance of this epigenetic memory during post-fertil ...

2019

DUX is a non-essential synchronizer of zygotic genome activation

Didier Trono, Sonia Verp, Sandra Eloise Kjeldsen, Alberto De Iaco, Delphine Yvette L Grun

Some of the earliest transcripts produced in fertilized human and mouse oocytes code for DUX, a double homeodomain protein that promotes embryonic genome activation (EGA). Deleting Dux by genome editing at the 1- to 2-cell stage in the mouse impairs EGA an ...

2019

PAX5 as a model to study the evolution of transcription factors' regulatory networks

Didier Trono, Alexandre Coudray, Filipe Amândio Brandão Sanches Vong Martins

E M H SWISS MEDICAL PUBLISHERS LTD2019

The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification

Didier Trono, Priscilla Turelli, Ruedi Aebersold, Julien Léonard Duc, Michaël Imbeault, Cécile Piot, Andrea Coluccio, Pierre-Yves Joseph Laurent Helleboid, Christian Axel Wandall Thorball, Julien Paul André Pontis

Krüppel‐associated box (KRAB)‐containing zinc finger proteins (KZFPs) are encoded in the hundreds by the genomes of higher vertebrates, and many act with the heterochromatin‐inducing KAP1 as repressors of transposable elements (TEs) during early embryogene ...

2019

ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer

Carine Delattre-Gubelmann, Didier Trono, Julien Léonard Duc, Bart Deplancke, Sunil Kumar Raghav, Marco Cassano, Michaël Imbeault, Petra Catalina Schwalie, Suk Min Jang, Riccardo Dainese, Julie Marie Russeil, Wanze Chen, Evgeniia Pankevich

Krüppel-associated box zinc finger proteins (KZFPs) constitute the largest family of mammalian transcription factors, but most remain completely uncharacterized. While initially proposed to primarily repress transposable elements, recent reports have revea ...

Nature Research2019

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