Publications de Anne-Laure Gassner

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Magnetic beads (MB) have now proven to be a powerful tool in both research and biomedical applications. They are available in a wide range of sizes (from nm to several µm) and their surface can be modified with molecules having biological specificities and ...

The present work reports on the quantification of total IgE in human serum using a microanalytical device whose fluidics is driven by gravity and capillary forces only. Thanks to the eight parallel microchannels in each microchip, calibration and sample an ...

A bubble cell capillary classically used to extend the optical path length for UV-vis detection is employed here to trap magnetic beads. With this system, a large amount of beads can be captured without inducing a strong pressure drop, as it is the case wi ...

Finite element numerical simulations were carried out in 2D geometries to map the magnetic field and force distribution produced by rectangular permanent magnets as a function of their size and position with respect to a microchannel. A single magnet, two ...

This review article summarizes the different fields of research at the Laboratoire d'Electrochimie Physique et Analytique at the Ecole Polytechnique Federale de Lausanne. The research areas covered include charge transfer reactions at soft interfaces, bio- ...

This paper introduces the concept of ring magnets for magnetic beads (MBs) trapping in a capillary. Such magnets enable an easy insertion of a capillary simply like a pearl on a string. With this system, high magnetic forces are obtained thanks to the prox ...

Magnetic core shell nanoparticles (MCSNPs) 30 nm diameter with a magnetic weight of 10% are usually much too small to be trapped in microfluidic systems using classical external magnets. Here, a simple microchip for efficient MCSNPs trapping and release is ...

Protein A-coated magnetic beads (0.3 μm) have been trapped in a small portion of a neutrally coated capillary (50 μm id). Anti-β-lactoglobulin (β-LG) antibodies have then been immobilized on the beads through strong affinity with protein A to subsequently ...

Magnetism-based microsystems, as those dedicated to immunoaffinity separations or (bio)chemical reactions, take benefit of the large surface area-to-volume ratio provided by the immobilized magnetic beads, thus increasing the sensitivity of the analysis. A ...

A soft stylus microelectrode probe has been developed to carry out scanning electrochemical microscopy (SECM) of rough, tilted, and large substrates in contact mode. It is fabricated by first ablating a microchannel in a polyethylene terephthalate thin fil ...

Two major milk whey proteins, β-lactoglobulin and α-lactalbumin, are among the main cowmilk allergens and can cause allergy even at a very low concentrations. Therefore, these proteins are interesting targets in food analysis, not only for food quality con ...

Anne-Laure Gassner

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Magnetic Stationary Phases for Protein Adsorption

Total serum IgE quantification by microfluidic ELISA using magnetic beads

Bubble cell for magnetic bead trapping in capillary electrophoresis

Magnetic forces produced by rectangular permanent magnets in static microsystems

LEPA: From Proteomics to Energy Conversion

Ring magnets for magnetic beads trapping in a capillary

Magnetic Core Shell Nanoparticles Trapping in a Microdevice Generating High Magnetic Gradient

Capillary electrophoresis immunoassay using magnetic beads

Magnetic track array for efficient bead capture in microchannels

Soft Stylus Probes for Scanning Electrochemical Microscopy

Analysis of major milk whey proteins by immunoaffinity capillary electrophoresis coupled with MALDI-MS

Allergy Diagnostics Using Magnetic Beads in a GRAVI-Cell Microfluidic Device