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Sami Jannin

Cette personne n’est plus à l’EPFL

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Publications associées (61)

Challenges in preparing, preserving and detecting para-water in bulk: overcoming proton exchange and other hurdles

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Nicola Salvi, Diego Carnevale, Roberto Buratto, Daniele Mammoli, Estel Canet Martinez

Para-water is an analogue of para-hydrogen, where the two proton spins are in a quantum state that is antisymmetric under permutation, also known as singlet state. The populations of the nuclear spin states in para-water are believed to have long lifetimes ...

Royal Society of Chemistry2015

Measuring absolute spin polarization in dissolution-DNP by Spin PolarimetrY Magnetic Resonance (SPY-MR)

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud, Quentin Chappuis

Dynamic nuclear polarization at 1.2 K and 6.7 T allows one to achieve spin temperatures on the order of a few millikelvin, so that the high-temperature approximation (Delta E < kT) is violated for the nuclear Zeeman interaction Delta E = gamma B(0)h/(2 pi) ...

Academic Press Inc - Elsevier Science2015

Hyperpolarized NMR of plant and cancer cell extracts at natural abundance

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud

Natural abundance C-13 NMR spectra of biological extracts are recorded in a single scan provided that the samples are hyperpolarized by dissolution dynamic nuclear polarization combined with cross polarization. Heteronuclear 2D correlation spectra of hyper ...

Royal Society of Chemistry2015

Drug Screening Boosted by Hyperpolarized Long-Lived States in NMR

Geoffrey Bodenhausen, Sandrine Gerber, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud, Nicola Salvi, Solène Marcelle Françoise Marie Passemard, Roberto Buratto, Aurélien Laguerre, Daniele Mammoli, Maninder Singh

Transverse and longitudinal relaxation times (T11 and T1) have been widely exploited in NMR to probe the binding of ligands and putative drugs to target proteins. We have shown recently that long-lived states (LLS) can be more sensitive to ligand binding. ...

Wiley-Blackwell2014

Hyperpolarization of Deuterated Metabolites via Remote Cross-Polarization and Dissolution Dynamic Nuclear Polarization

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud

In deuterated molecules such as [1-C-13]pyruvate-d(3), the nuclear spin polarization of C-13 nuclei can be enhanced by combining Hartmann-Hahn cross-polarization (CP) at low temperatures (1.2 K) with dissolution dynamic nuclear polarization (D-DNP). The po ...

American Chemical Society2014

Procédé de spectroscopie RMN avec dégradations d'induction prolongée de cohérences aux temps de vie longs

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet

A Method for nuclear magnetic resonance (NMR) spectroscopy of a sample comprising the following steps: (a) excitation of long lived coherences (LLC) between the singlet state So and the central triplet state To of nuclei of the sample by initiating irradia ...

2014

Toward Quantitative Measurements of Enzyme Kinetics by Dissolution Dynamic Nuclear Polarization

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Daniel Abergel

Dissolution dynamic nuclear polarization (D-DNP) experiments enabled us to study the kinetics of the enzymatic phosphorylation reaction of glucose to form glucose-6-phosphate (G6P) by hexokinase (HK), with or without the presence of an excess of G6P, which ...

2014

Cross polarization from H-1 to quadrupolar Li-6 nuclei for dissolution DNP

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud, Angel Joaquin Perez Linde

Cross polarization from protons to quadrupolar Li-6 nuclei is combined with dynamic nuclear polarization of protons at 1.2 K and 6.7 T using TEMPOL as a polarizing agent followed by rapid dissolution. Compared to direct Li-6 DNP without cross-polarization, ...

Royal Society of Chemistry2014

Method for hyperpolarization transfer in the liquid state

Geoffrey Bodenhausen, Sami Jannin

A method for producing a hyperpolarized sample for use in a magnetic resonance investigation, with the following steps: a) providing a solid sample (50), containing long T1 nuclei and short T1 nuclei in the same molecules (51) b) hyperpolarizing the short ...

2014

Long-Lived States of Magnetically Equivalent Spins Populated by Dissolution-DNP and Revealed by Enzymatic Reactions

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud, Daniele Mammoli, Xiao Ji

Hyperpolarization by dissolution dynamic nuclear polarization (D-DNP) offers a way of enhancing NMR signals by up to five orders of magnitude in metabolites and other small molecules. Nevertheless, the lifetime of hyperpolarization is inexorably limited, a ...

Wiley-Blackwell2014

Hybrid polarizing solids for pure hyperpolarized liquids through dissolution dynamic nuclear polarization

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud, David Benjamin Roger Antoine Gajan, David Lyndon Emsley

Hyperpolarization of substrates for magnetic resonance spectroscopy (MRS) and imaging (MRI) by dissolution dynamic nuclear polarization (D-DNP) usually involves saturating the ESR transitions of polarizing agents (PAs; e.g., persistent radicals embedded in ...

National Academy of Sciences2014

Microwave frequency modulation to enhance Dissolution Dynamic Nuclear Polarization Dedicated to To Martial Rey, as a token of appreciation

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud, Angel Joaquin Perez Linde

Hyperpolarization by Dissolution Dynamic Nuclear Polarization is usually achieved by monochromatic microwave irradiation of the ESR spectrum of free radicals embedded in glasses at 1.2 K and 3.35 T. Hovav et al. (2014) have recently shown that by using fre ...

Elsevier2014

Boosting Dissolution Dynamic Nuclear Polarization by Cross Polarization

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Angel Joaquin Perez Linde

The efficiency of dissolution dynamic nuclear polarization can be boosted by Hartmann-Hahn cross polarization at temperatures near 1.2 K. This enables high throughput of hyperpolarized solutions with substantial gains in buildup times and polarization leve ...

Amer Chemical Soc2013

An apparatus for pulsed ESR and DNP experiments using optically excited triplet states down to liquid helium temperatures

Arnaud Comment, Jacques Van Der Klink, Sami Jannin, Tim Rolf Eichhorn, Martin Haag

In standard Dynamic Nuclear Polarization (DNP) electron spins are polarized at low temperatures in a strong magnetic field and this polarization is transferred to the nuclear spins by means of a microwave field. To obtain high nuclear polarizations cryogen ...

Academic Press2013

Methods for nuclear magnetic resonance (NMR) or magnetic resonance imaging (MRI) measurements using long-lived states

Arnaud Comment, Geoffrey Bodenhausen, Sami Jannin, Riddhiman Sarkar, Paul Romeo Vasos

A method for nuclear magnetic resonance (NMR) or magnetic resonance imaging (MRI) measurements, includes creation of enhanced polarization of nuclei of a first kind within a sample in a magnetic field at cryogenic temperatures and transfer of the polarized ...

2013

Method and device for rapid dnp

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet

A method for producing hyperpolarized sample material for use in magnetic resonance investigations, with a) preparing a target material, containing high gamma nuclei with a short T1, - a polarizing agent with a broad EPR line, and low gamma nuclei with a l ...

2013

Dynamic Nuclear Polarization by Thermal Mixing Under Partial Saturation

Arnaud Comment, Sami Jannin

We describe a low-temperature thermodynamic model for dynamic nuclear polarization (DNP) via continuous-wave partial saturation of electron spin resonance (ESR) lines that are both homogeneously and inhomogeneously broadened. It is a variant of a reasoning ...

Springer Vienna2012

Dynamic Nuclear Polarization and Other Magnetic Ideas at EPFL

Geoffrey Bodenhausen, Martial Rey, Sami Jannin, Aurélien Bornet, Jonas Milani, Simone Ulzega, Pascal Miéville, Marc Anthony Caporini, Nicola Salvi, Diego Carnevale, Roberto Buratto, Srinivas Chinthalapalli, Shutao Wang, Daniele Mammoli, Angel Joaquin Perez Linde

Although nuclear magnetic resonance (NMR) can provide a wealth of information, it often suffers from a lack of sensitivity. Dynamic Nuclear Polarization (DNP) provides a way to increase the polarization and hence the signal intensities in NMR spectra by tr ...

2012

Ultrahigh-Resolution Magnetic Resonance in Inhomogeneous Magnetic Fields: Two-Dimensional Long-Lived-Coherence Correlation Spectroscopy

Geoffrey Bodenhausen, Sami Jannin, Riddhiman Sarkar, Aurélien Bornet, Srinivas Chinthalapalli

A half-century quest for improving resolution in Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI) has enabled the study of molecular structures, biological interactions, and fine details of anatomy. This progress largely relied on the ...

2012

Cross Polarization for Dissolution Dynamic Nuclear Polarization Experiments at Readily Accessible Temperatures 1.2 < T < 4.2 K

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet

Cross polarization can provide significant enhancements with respect to direct polarization of low-gamma nuclei such as C-13. Substantial gains in sample throughput (shorter polarization times) can be achieved by exploiting shorter build-up times tau(DNP)( ...

Springer Verlag2012

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