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Melody Swartz

Cette personne n’est plus à l’EPFL

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Publications associées (136)

Matrix-binding checkpoint immunotherapies enhance antitumor efficacy and reduce adverse events

Jeffrey Alan Hubbell, Melody Swartz, Lambert Charles François Potin, Hans Mattias Larsson, Gabriele Galliverti, Jun Ishihara, Kazuto Fukunaga

Immune checkpoint blockade exhibits considerable antitumor activity, but previous studies have reported instances of severe treatment-related adverse events. We sought to explore local immune checkpoint blockade, with an antibody (Ab) form that would be re ...

Amer Assoc Advancement Science2017

Exploiting lymphatic vessels for immunomodulation: Rationale, opportunities, and challenges

Melody Swartz, Lambert Charles François Potin

Lymphatic vessels are the primary route of communication from peripheral tissues to the immune system; as such, they represent an important component of local immunity. In addition to their transport functions, new immunomodulatory roles for lymphatic vess ...

Elsevier Science Bv2017

Oxidation-sensitive polymersomes as vaccine nanocarriers enhance humoral responses against Lassa virus envelope glycoprotein

Jeffrey Alan Hubbell, Melody Swartz, Sachiko Hirosue, Marcela Rincón-Restrepo, Clara Galan Navarro, Stefan Kunz

Lassa virus (LASV) causes severe hemorrhagic fever with high mortality, yet no vaccine currently exists. Antibodies targeting viral attachment proteins are crucial for protection against many viral infections. However, the envelope glycoprotein (GP) 1 of L ...

Academic Press Inc Elsevier Science2017

Perivascular Macrophages Limit Permeability

Melody Swartz, Witold Waldemar Kilarski, Esra Güç, Michele De Palma, Mario Leonardo Squadrito

Objective-Perivascular cells, including pericytes, macrophages, smooth muscle cells, and other specialized cell types, like podocytes, participate in various aspects of vascular function. However, aside from the well-established roles of smooth muscle cell ...

American Heart Association2016

Lymphatic vessels regulate immune microenvironments in human and murine melanoma

Melody Swartz, Amanda Waite Lund, Manuel Andreas Fankhauser, Maria Anna Sofia Broggi

Lymphatic remodeling in tumor microenvironments correlates with progression and metastasis, and local lymphatic vessels play complex and poorly understood roles in tumor immunity. Tumor lymphangiogenesis is associated with increased immune suppression, yet ...

Amer Soc Clinical Investigation Inc2016

Fibronectin EDA and CpG synergize to enhance antigen-specific Th1 and cytotoxic responses

Jeffrey Alan Hubbell, Melody Swartz, Alexandre de Titta, Ziad Julier, Eleonora Simeoni, Alizée Jéléna Grimm

Subunit vaccines, employing purified protein antigens rather than intact pathogens, require the addition of adjuvants for enhanced immunogenicity with a correct balance between strong activation of the immune system and low toxicity. Here we show that the ...

Elsevier Sci Ltd2016

A Cationic Micelle Complex Improves CD8+T Cell Responses in Vaccination Against Unmodified Protein Antigen

Jeffrey Alan Hubbell, Melody Swartz, Davide Demurtas, Vasiliki Panagiotou, Carrie Ellen Brubaker, Daniel Kenneth Bonner

Nanoscale carrier platforms promote immune responses to vaccination by facilitating delivery of vaccine components to immunologically relevant sites. The technique is particularly valuable for subunit vaccination, in which coadministration of immunostimula ...

Amer Chemical Soc2016

ADAM17 Promotes Motility, Invasion, and Sprouting of Lymphatic Endothelial Cells

Melody Swartz, Witold Waldemar Kilarski, Renata Katarzyna Mezyk-Kopec

Tumor-associated lymphatic vessels actively participate in tumor progression and dissemination. ADAM17, a sheddase for numerous growth factors, cytokines, receptors, and cell adhesion molecules, is believed to promote tumor development, facilitating both t ...

Public Library Science2015

Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation

Melody Swartz, Cathrin Brisken, Witold Waldemar Kilarski, Elena Menietti, Dania Al Labban, Csaba Ferenc László

Stromal fibroblast senescence has been linked to ageing-associated cancer risk. However, density and proliferation of cancer-associated fibroblasts (CAFs) are frequently increased. Loss or downmodulation of the Notch effector CSL (also known as RBP-Jκ) in ...

Nature Publishing Group2015

An in vitro model of the tumor-lymphatic microenvironment with simultaneous transendothelial and luminal flows reveals mechanisms of flow enhanced invasion

Melody Swartz, Marco Pisano, Valentina Triacca

The most common cancers, including breast and skin, disseminate initially through the lymphatic system, yet the mechanisms by which tumor cells home towards, enter and interact with the lymphatic endothelium remain poorly understood. Transmural and luminal ...

Royal Soc Chemistry2015

6-Thioguanine-loaded polymeric micelles deplete myeloid-derived suppressor cells and enhance the efficacy of T cell immunotherapy in tumor-bearing mice

Jeffrey Alan Hubbell, Melody Swartz, Iraklis Kourtis, Laura Jeanbart

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that suppress effector T cell responses and can reduce the efficacy of cancer immunotherapies. We previously showed that ultra-small polymer nanoparticles eff ...

Springer2015

Associations of lymphangiogenesis with immune profiles of melanoma patients

Melody Swartz, Natacha Anne-Sophie Bordry

Amer Assoc Cancer Research2015

Nanoparticle conjugation enhances the immunomodulatory effects of intranasally delivered CpG in house dust mite-allergic mice

Jeffrey Alan Hubbell, Melody Swartz, Alexandre de Titta, Marie Ballester, Laura Jeanbart, Benjamin John Marsland

An emerging strategy in preventing and treating airway allergy consists of modulating the immune response induced against allergens in the lungs. CpG oligodeoxynucleotides have been investigated in airway allergy studies, but even if promising, efficacy re ...

Nature Publishing Group2015

Investigation of T Lymphocyte Dynamics in an In Vitro Model of the Lymph Node Stroma

Melody Swartz, Cara Field Buchanan

Mary Ann Liebert, Inc2015

Recapitulation of the Tumor Microenvironment In Vitro using a Novel Perfusion Bioreactor: Towards Personalized Tumor Models

Melody Swartz, Marco Pisano, Valentina Triacca

Mary Ann Liebert, Inc2015

Engineering Interactions between Growth Factors and the Extracellular Matrix

Mikaël Martino, Jeffrey Alan Hubbell, Melody Swartz, Priscilla Suhasna Maithili Briquez, Witold Waldemar Kilarski, Esra Güç

Federation Amer Soc Exp Biol2015

Engineering opportunities in cancer immunotherapy

Melody Swartz, Laura Jeanbart

Immunotherapy has great potential to treat cancer and prevent future relapse by activating the immune system to recognize and kill cancer cells. A variety of strategies are continuing to evolve in the laboratory and in the clinic, including therapeutic non ...

National Academy of Sciences2015

Collecting Lymphatic Vessel Permeability Facilitates Adipose Tissue Inflammation and Distribution of Antigen to Lymph Node-Homing Adipose Tissue Dendritic Cells

Melody Swartz, Wei Wang

Collecting lymphatic vessels (CLVs), surrounded by fat and endowed with contractile muscle and valves, transport lymph from tissues after it is absorbed into lymphatic capillaries. CLVs are not known to participate in immune responses. In this study, we ob ...

American Association of Immunologists ; Oxford University Press2015

Dermal lymphatic vessels are required for the induction of local inflammation in a B16 F10 murine melanoma

Melody Swartz, Amanda Waite Lund, Manuel Andreas Fankhauser

Amer Assoc Cancer Research2015

Optimization and regeneration kinetics of lymphatic-specific photodynamic therapy in the mouse dermis

Melody Swartz, Patrycja Nowak-Sliwinska, Witold Waldemar Kilarski, Renata Katarzyna Mezyk-Kopec

Lymphatic vessels transport fluid, antigens, and immune cells to the lymph nodes to orchestrate adaptive immunity and maintain peripheral tolerance. Lymphangiogenesis has been associated with inflammation, cancer metastasis, autoimmunity, tolerance and tra ...

Springer2014

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