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Patrick Segers

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Publications associées (38)

Ascending Aortic Aneurysm in Angiotensin II–Infused Mice: Formation, Progression, and the Role of Focal Dissections

Nikolaos Stergiopoulos, Patrick Segers, Jessica Sordet, Alessandra Piersigilli, Bram Trachet, Lydia Aslanidou

Objective To understand the anatomy and physiology of ascending aortic aneurysms in angiotensin II-infused ApoE(-/-) mice. Approach and Results We combined an extensive in vivo imaging protocol (high-frequency ultrasound and contrast-enhanced microcomputed ...

2016

Incidence, severity, mortality, and confounding factors for dissecting AAA detection in angiotensin II-infused mice: a meta-analysis

Nikolaos Stergiopoulos, Patrick Segers, Bram Trachet

Aims While angiotensin II-infused mice are the most popular model for preclinical aneurysm research, representative data on incidence, severity, and mortality of dissecting abdominal aortic aneurysms (AAAs) have never been established, and the influence of ...

Oxford University Press2015

Performance Comparison of Ultrasound-Based Methods to Assess Aortic Diameter and Stiffness in Normal and Aneurysmal Mice

Nikolaos Stergiopoulos, Patrick Segers, Bram Trachet

Objective Several ultrasound-based methods are currently used to assess aortic diameter, circumferential strain and stiffness in mice, but none of them is flawless and a gold standard is lacking. We aimed to assess the validity and sensitivity of these met ...

Public Library Science2015

Dissecting abdominal aortic aneurysm in Ang II-infused mice: suprarenal branch ruptures and apparent luminal dilatation

Nikolaos Stergiopoulos, Patrick Segers, Jessica Sordet, Alessandra Piersigilli, Bram Trachet, Peter Modregger

Aims In this work, we provide novel insight into the morphology of dissecting abdominal aortic aneurysms in angiotensin II-infused mice. We demonstrate why they exhibit a large variation in shape and, unlike their human counterparts, are located suprarenal ...

Oxford University Press2015

An Animal-Specific FSI Model of the Abdominal Aorta in Anesthetized Mice

Nikolaos Stergiopoulos, Patrick Segers, Bram Trachet

Recent research has revealed that angiotensin II-induced abdominal aortic aneurysm in mice can be related to medial ruptures occurring in the vicinity of abdominal side branches. Nevertheless a thorough understanding of the biomechanics near abdominal side ...

Springer2015

Dissecting Abdominal Aortic Aneurysm in Angiotensin II-Infused Mice: The Importance of Imaging

Nikolaos Stergiopoulos, Patrick Segers, Alessandra Piersigilli, Bram Trachet

Introduction. Since the initial publication in 2000, Angiotensin II-infused mice have become one of the most popular models to study abdominal aortic aneurysm in a pre-clinical setting. We recently used phase contrast X-ray based computed tomography to dem ...

2015

Vulnerable Plaque Detection and Quantification with Gold Particle-Enhanced Computed Tomography in Atherosclerotic Mouse Models

Patrick Segers, Bram Trachet

Recently, an apolipoprotein E-deficient (ApoE(-/-)) mouse model with a mutation (C1039G+/-) in the fibrillin-1 (Fbn1) gene (ApoE(-/-)Fbn1(C1039G+/-) mouse model) was developed showing vulnerable atherosclerotic plaques, prone to rupture, in contrast to the ...

B C Decker Inc2015

Branch-related ruptures cause intramural hematoma and dissecting abdominal aortic aneurysm in angiotensin II-infused ApoE-/- mice

Nikolaos Stergiopoulos, Patrick Segers, Alessandra Piersigilli, Bram Trachet, Lydia Aslanidou

Oxford Univ Press2015

Quantification of focal lacerations in the tunica media that cause ascending aortic aneurysm in angiotensin II-infused mice

Nikolaos Stergiopoulos, Patrick Segers, Alessandra Piersigilli, Bram Trachet, Lydia Aslanidou

Oxford Univ Press2015

Ambulatory arterial stiffness index does not accurately assess arterial stiffness

Nikolaos Stergiopoulos, Philippe Reymond, Patrick Segers

Introduction: The ambulatory arterial stiffness index (AASI), derived from ambulatory blood pressure monitoring (ABPM) recordings, has been proposed as a surrogate marker of arterial stiffness. However, there is controversy to what extent it reflects stiff ...

Lippincott, Williams & Wilkins2012

Validation of the arteriograph working principle: questions still remain - reply 2

Nikolaos Stergiopoulos, Philippe Reymond, Patrick Segers, Bram Trachet

2011

Validation of the Arteriograph working principle: questions still remain

Nikolaos Stergiopoulos, Philippe Reymond, Patrick Segers, Bram Trachet

Lippincott, Williams & Wilkins2011

Numerical validation of a new method to assess aortic pulse wave velocity from a single recording of a brachial artery waveform with an occluding cuff

Nikolaos Stergiopoulos, Philippe Reymond, Patrick Segers, Bram Trachet

Recently a new method has been proposed as a tool to measure arterial pulse wave velocity (PWV), a measure of the stiffness of the large arteries and an emerging parameter used as indicator of clinical cardiovascular risk. The method is based on measuremen ...

Springer Verlag2010

Three- and four-element Windkessel models: assessment of their fitting performance in a large cohort of healthy middle-aged individuals

Nikolaos Stergiopoulos, Nico Westerhof, Patrick Segers

Lumped-parameter models are used to estimate the global arterial properties by fitting the model to measured (aortic) pressure and flow. Different model configurations coexist, and it is still an open question as to which model optimally reflects the arter ...

2008

Effect of an abdominal aortic aneurysm on wave reflection in the aorta

Nikolaos Stergiopoulos, Patrick Segers

Despite extensive attention to abdominal aortic aneurysm (AAA) in the biomedical engineering community, its effect on aortic hemodynamics and arterial wave reflection has not been addressed before. We used experimental and numerical methods, relying on a r ...

2008

Effects of an aging vascular model on healthy and diseased hearts

Nikolaos Stergiopoulos, David Jegger, Patrick Segers, Rafaela Fernandes Da Silva

The vitamin D(3) and nicotine (VDN) model is a model of isolated systolic hypertension (ISH) due to arterial calcification raising arterial stiffness and vascular impedance similar to an aged and stiffened arterial tree. We therefore analyzed the impact of ...

2007

Noninvasive Doppler-derived myocardial performance index in rats with myocardial infarction: validation and correlation by conductance catheter

Nikolaos Stergiopoulos, David Jegger, Patrick Segers

The rodent model of myocardial infarction (MI) is extensively used in heart failure studies. However, long-term follow-up of echocardiographic left ventricular (LV) function parameters such as the myocardial performance index (MPI) and its ratio with the f ...

2005

Nonlinear isochrones in murine left ventricular pressure-volume loops: how well does the time-varying elastance concept hold?

Nikolaos Stergiopoulos, Nico Westerhof, Patrick Segers

The linear time-varying elastance theory is frequently used to describe the change in ventricular stiffness during the cardiac cycle. The concept assumes that all isochrones (i.e., curves that connect pressure-volume data occurring at the same time) are li ...

2005

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