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Carl Petersen

Cette personne a quitté l’EPFL

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Publications associées (86)

Page 1 sur 5

Genetic manipulation, whole-cell recordings and functional imaging of the sensorimotor cortex of behaving mice

Carl Petersen

Sensory processing, sensorimotor integration and motor control are amongst the most basic functions of the brain and yet our understanding of how the underlying neuronal networks operate and contribute to behaviour is very limited. The relative simplicity ...

2009

Unique functional properties of somatostatin-expressing GABAergic neurons in mouse barrel cortex

Carl Petersen, Yves Emile Alfred Kremer

Neocortical GABAergic neurons have diverse molecular, structural and electrophysiological features, but the functional correlates of this diversity are largely unknown. We found unique membrane potential dynamics of somatostatin-expressing (SOM) neurons in ...

Nature Publishing Group2012

Microcircuits of excitatory and inhibitory neurons in layer 2/3 of mouse barrel cortex

Wulfram Gerstner, Carl Petersen, Céline Matéo, Michael Avermann, Christian Tomm

Avermann M, Tomm C, Mateo C, Gerstner W, Petersen CC. Microcircuits of excitatory and inhibitory neurons in layer 2/3 of mouse barrel cortex. J Neurophysiol 107: 3116-3134, 2012. First published March 7, 2012; doi:10.1152/jn.00917.2011.-Synaptic interactio ...

American Physiological Society2012

Striatal Dopamine Signals and Reward Learning

Meriam Malekzadeh, Robin François Virginien Dard, Carl Petersen, Sylvain Crochet, Yanqi Liu, Parviz Ghaderi, Christos Sourmpis, Pol Bech Vilaseca, Mauro Pulin, Anthony Pierre Robert Renard

We are constantly bombarded by sensory information and constantly making decisions on how to act. In order to optimally adapt behavior, we must judge which sequences of sensory inputs and actions lead to successful outcomes in specific circumstances. Neuro ...

Oxford Univ Press2023

Neuronal Circuits In Barrel Cortex For Whisker Sensory Perception

Carl Petersen

The array of whiskers on the snout provides rodents with tactile sensory information relating to the size, shape and texture of objects in their immediate environment. Rodents can use their whiskers to detect stimuli, distinguish textures, locate objects a ...

AMER PHYSIOLOGICAL SOC2021

Cell-class-specific orofacial motor maps in mouse neocortex

Léa Marie Veaute, Hidenobu Mizuno, Carl Petersen, Sylvain Crochet, Keita Tamura, Pol Bech Vilaseca

Cortical motor maps represent fundamental organizing principles for voluntary motor control,1 yet their underlying structure remains poorly understood, including regions of sensory2,3 and parietal cortex,4 as well as the classical frontal motor cortex. To ...

2025

Neural Circuits for Goal-Directed Sensorimotor Transformations

Carl Petersen, Sylvain Crochet

Precisely wired neuronal circuits process sensory information in a learning- and context-dependent manner in order to govern behavior. Simple sensory decision-making tasks in rodents are now beginning to reveal the contributions of distinct cell types and ...

ELSEVIER SCIENCE LONDON2019

Voltage-sensitive dye imaging of mouse neocortex during a whisker detection task

Carl Petersen, Matthieu Pierre Auffret, Alexandros Kyriakatos

Sensorimotor processing occurs in a highly distributed manner in the mammalian neocortex. The spatiotemporal dynamics of electrical activity in the dorsal mouse neocortex can be imaged using voltage-sensitive dyes (VSDs) with near-millisecond temporal reso ...

SPIE-Intl Soc Optical Eng2017

Long-range connectivity of mouse primary somatosensory barrel cortex

Carl Petersen, Bernard Schneider, Céline Matéo

The primary somatosensory barrel cortex processes tactile vibrissae information, allowing rodents to actively perceive spatial and textural features of their immediate surroundings. Each whisker on the snout is individually represented in the neocortex by ...

Wiley-Blackwell2010

Axonal and Dendritic Morphology of Excitatory Neurons in Layer 2/3 Mouse Barrel Cortex Imaged Through Whole-Brain Two-Photon Tomography and Registered to a Digital Brain Atlas

Carl Petersen, Sylvain Crochet, Georgios Foustoukos, Yanqi Liu

Communication between cortical areas contributes importantly to sensory perception and cognition. On the millisecond time scale, information is signaled from one brain area to another by action potentials propagating across long-range axonal arborizations. ...

FRONTIERS MEDIA SA2022

Dynamic I-V curves are reliable predictors of naturalistic pyramidal-neuron voltage traces

Wulfram Gerstner, Carl Petersen, Laurent Badel, Sandrine Lefort

Neuronal response properties are typically probed by intracellular measurements of current-voltage (I-V) relationships during application of current or voltage steps. Here we demonstrate the measurement of a novel I-V curve measured while the neuron exhibi ...

American Physiological Society2008

Layer, column and cell-type specific genetic manipulation in mouse barrel cortex

Carl Petersen

Sensory information is processed in distributed neuronal networks connected by intricate synaptic circuits. Studies of the rodent brain can provide insight into synaptic mechanisms of sensory perception and associative learning. In particular, the mouse wh ...

Frontiers Research Foundation2008

Connection-type-specific biases make uniform random network models consistent with cortical recordings

Wulfram Gerstner, Carl Petersen, Tim Vogels, Michael Avermann, Christian Tomm

Uniform random sparse network architectures are ubiquitous in computational neuroscience, but the implicit hypothesis that they are a good representation of real neuronal networks has been met with skepticism. Here we used two experimental data sets, a stu ...

American Physiological Society2014

Layer- and column-specific knockout of NMDA receptors in pyramidal neurons of the mouse barrel cortex

Carl Petersen

Viral vectors injected into the mouse brain offer the possibility for localized genetic modifications in a highly controlled manner. Lentivector injection into mouse neocortex transduces cells within a diameter of approximately 200mum, which closely matche ...

Frontiers Research Foundation2007

Internal brain state regulates membrane potential synchrony in barrel cortex of behaving mice

Carl Petersen

Internal brain states form key determinants for sensory perception, sensorimotor coordination and learning. A prominent reflection of different brain states in the mammalian central nervous system is the presence of distinct patterns of cortical synchrony, ...

Nature Publishing Group2008

Parallel pathways from motor and somatosensory cortex for controlling whisker movements in mice

Carl Petersen, Varun Sreenivasan

Mice can gather tactile sensory information by actively moving their whiskers to palpate objects in their immediate surroundings. Whisker sensory perception therefore requires integration of sensory and motor information, which occurs prominently in the ne ...

Wiley-Blackwell2015

Distributed and specific encoding of sensory, motor, and decision information in the mouse neocortex during goal-directed behavior

Wulfram Gerstner, Carl Petersen, Sylvain Crochet, Alireza Modirshanechi, Vahid Esmaeili, Anastasiia Oryshchuk, Christos Sourmpis

Goal-directed behaviors involve coordinated activity in many cortical areas, but whether the encoding of task variables is distributed across areas or is more specifically represented in distinct areas remains unclear. Here, we compared representations of ...

Cell Press2023

In Vivo Optogenetic Stimulation of Neocortical Excitatory Neurons Drives Brain-State-Dependent Inhibition

Carl Petersen, Céline Matéo, Michael Avermann

Background: Synaptic interactions between excitatory and inhibitory neocortical neurons are important for mammalian sensory perception. Synaptic transmission between identified neurons within neocortical microcircuits has mainly been studied in brain slice ...

Elsevier2011

Visualizing the cortical representation of whisker touch: voltage-sensitive dye imaging in freely moving mice

Carl Petersen

Voltage-sensitive dye imaging resolves the spatiotemporal dynamics of supragranular subthreshold cortical activity with millisecond temporal resolution and subcolumnar spatial resolution. We used a flexible fiber optic image bundle to visualize voltage-sen ...

2006

Cortical sensory processing across motivational states during goal-directed behavior

Carl Petersen, Georgios Foustoukos, Matthieu Pierre Auffret, Sami El-Boustani, Johannes Maria Mayrhofer

Behavioral states can influence performance of goal-directed sensorimotor tasks. Yet, it is unclear how altered neuronal sensory representations in these states relate to task performance and learning. We trained water-restricted mice in a two-whisker disc ...

2022