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Harm-Anton Klok

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Publications associées (195)

NMR diffusion and relaxation studies of the encapsulation of fragrances by amphiphilic multiarm star block copolymers

John Christopher Plummer, Céline Ternat, Harm-Anton Klok

Self-diffusion NMR spectroscopy and relaxometry have been employed to study fragrance encapsulation in water-soluble, amphiphilic star block copolymers. Diffusion coefficients of four different fragrance molecules in the free form and in the presence of th ...

American Chemical Society2007

Synthesis of poly(methacrylic acid) brushes via surface-initiated atom transfer radical polymerization of sodium methacrylate and their use as substrates for the mineralization of calcium carbonate

Raphaël Barbey, Harm-Anton Klok, Stefano Tugulu

This manuscript describes the synthesis of poly(methacrylic acid) (PMAA) brushes via surface-initiated atom transfer radical polymerization (SI-ATRP) of sodium methacrylate (NaMA) and their use as substrates for the mineralization of calcium carbonate. A C ...

American Chemical Society2007

Solid-state structure, organization and properties of peptide-synthetic hybrid block copolymers

Harm-Anton Klok

Peptide-synthetic hybrid block copolymers are most easily prepared via ring-opening polymerization of ?-amino acid N-carboxyanhydrides using appropriately end-functionalized synthetic polymers as the macroinitiator. This class of peptide-synthetic hybrid b ...

2006

Water-soluble, unimolecular containers based on amphiphilic multiarm star block copolymers

John Christopher Plummer, Céline Ternat, Harm-Anton Klok

A new class of water-soluble, amphiphilic star block copolymers with a large number of arms was prepared by sequential atom transfer radical polymerization (ATRP) of n-butyl methacrylate (BMA) and poly-(ethylene glycol) methyl ether methacrylate (PEGMA). A ...

American Chemical Society2006

Thermodynamic confinement and α-helix persistence length in poly(γ-benzyl-L-glutamate)-b-poly(dimethyl siloxane)-b-poly(γ-benzyl-L-glutamate) triblock copolymers

Harm-Anton Klok

The structure and the associated dynamics of a series of poly(?-benzyl-L-glutamate)-b-poly(dimethyl siloxane)-b-poly(?-benzyl-L-glutamate) (PBLG-b-PDMS-b-PBLG) triblock copolymers were investigated using small- and wide-angle X-ray scattering, NMR, transmi ...

American Chemical Society2006

Protein function microarrays based on self-immobilizing and self-labeling fusion proteins

Kai Johnsson, India Christina Sielaff, Harm-Anton Klok, Anke Arnold, Stefano Tugulu

Protein microarrays are an attractive approach for the high-throughput analysis of protein function, but their impact on proteomics has been limited by the technical difficulties associated with their generation. Here we demonstrate that fusion proteins of ...

2006

Synthesis of uniform, non-natural oligomers

Harm-Anton Klok, Nadja Franz

Oligomers with well-defined chain lengths are of interest as foldamers, are important as model compounds for high-molecular-weight polymers and find application in electrooptic and sensory devices. This account presents an overview of the strategies that a ...

2006

Protein-functionalized polymer brushes

Kai Johnsson, India Christina Sielaff, Harm-Anton Klok, Anke Arnold, Stefano Tugulu

Understanding and controlling the interactions between synthetic and biol. materials is of great importance for the development of novel materials for a variety of biomedical and bioanal. applications, including for example stents, vascular grafts and prot ...

2005

Nonspherical assemblies generated from polystyrene-b-poly(L-lysine) polyelectrolyte block copolymers

Jutta Christine Wandrey, Laurent Bourdillon, Harm-Anton Klok, Harald Nuhn, Markus Scholl

This report describes the aqueous solution self-assembly of a series of polystyrenem-b-poly(L-lysine)n block copolymers (m = 8-10; n = 10-70). The polymers are prepared by ring-opening polymerization of e-benzyloxycarbonyl-L-lysine AT-carboxyanhydride usin ...

2005

PEG-based hybrid block copolymers containing α-helical coiled coil peptide sequences: Control of self-assembly and preliminary biological evaluation

Harm-Anton Klok

This study investigates the structure and organization of a series of hybrid diblock copolymers based on polyethylene glycol) (PEG) and peptide sequences inspired by the coiled coil protein folding motif. Circular dichroism spectroscopy and analytical ultr ...

American Chemical Society2005

L-lysine dendronized polystyrene

Harm-Anton Klok

This paper reports the synthesis and characterization of a novel class of dendronized polymers which are based on styrene functionalized dendritic L-lysine macromonomers. Free radical polymerization of zeroth and first generation macromonomers afforded den ...

American Chemical Society2005

Solution self-assembly of hybrid block copolymers containing poly(ethylene glycol) and amphiphilic peptide sequences

Harm-Anton Klok, Harald Nuhn

The self-assembly in aqueous solution of hybrid block copolymers consisting of amphiphilic ?-strand peptide sequences flanked by one or two PEG chains was investigated by means of circular dichroism spectroscopy, small-angle X-ray scattering, and transmiss ...

American Chemical Society2005

Biological-synthetic hybrid block copolymers: Combining the best from two worlds

Harm-Anton Klok

Although biopolymers and synthetic polymers share many common features, each of these two classes of materials is also characterized by a distinct and very specific set of advantages and disadvantages. Combining biopolymer elements with synthetic polymers ...

2005

Protein-Functionalized Polymer Brushes

Kai Johnsson, India Christina Sielaff, Harm-Anton Klok, Anke Arnold, Stefano Tugulu

A new strategy for the prepn. of protein-functionalized polymer brushes is reported, which is based on a combination of surface-initiated atom transfer radical polymn. (ATRP), p-nitrophenyl chloroformate activation of the surface hydroxyl groups, and subse ...

American Chemical Society2005

Polyphenylene dendrimers as scaffolds for shape-persistent multiple peptide conjugates

Harm-Anton Klok

The present work describes synthetic concepts for the coupling of peptides to polyphenylene dendrimers (PPDs). Novel functionalized cyclopentadienones have been synthesized whose Diels-Alder cycloaddition with various core molecules leads to polyphenylene ...

2005

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