Publications de Henry Markram | EPFL Graph Search

Publications associées (167)

Excitation states of metabolic networks predict dose-response fingerprinting and ligand pulse phase signalling

Pierre Magistretti, Henry Markram, Felix Schürmann, Daniel Keller, Jay Coggan

With a computational model of energy metabolism in an astrocyte, we show how a system of enzymes in a cascade can act as a functional unit of interdependent reactions, rather than merely a series of independent reactions. These systems may exist in multipl ...

2020

NEOBASE: databasing the neocortical microcircuit

Henry Markram

Mammals adapt to a rapidly changing world because of the sophisticated perceptual and cognitive function enabled by the neocortex. The neocortex, which has expanded to constitute nearly 80% of the human brain seems to have arisen from repeated duplication ...

2005

A method to estimate the cellular composition of the mouse brain from heterogeneous datasets

Henry Markram, Daniel Keller, Michael Reimann, Marc-Oliver Gewaltig, Srikanth Ramaswamy, Dimitri Bruno Marie Rodarie, Yann Roussel, Csaba Verasztó

The mouse brain contains a rich diversity of inhibitory neuron types that have been characterized by their patterns of gene expression. However, it is still unclear how these cell types are distributed across the mouse brain. We developed a computational m ...

2022

A Brief History of Simulation Neuroscience

Xue Fan, Henry Markram

Our knowledge of the brain has evolved over millennia in philosophical, experimental and theoretical phases. We suggest that the next phase is simulation neuroscience. The main drivers of simulation neuroscience are big data generated at multiple levels of ...

2019

Optimum trajectory learning in musculoskeletal systems with model predictive control and deep reinforcement learning

Henry Markram, Marc-Oliver Gewaltig

From the computational point of view, musculoskeletal control is the problem of controlling high degrees of freedom and dynamic multi-body system that is driven by redundant muscle units. A critical challenge in the control perspective of skeletal joints w ...

2022

Brain Metabolism in Health and Neurodegeneration: The Interplay Among Neurons and Astrocytes

Henry Markram, Daniel Keller, Jay Coggan, Polina Shichkova

The regulation of energy in the brain has garnered substantial attention in recent years due to its significant implications in various disorders and aging. The brain’s energy metabolism is a dynamic and tightly regulated network that balances energy deman ...

MDPI AG2024

Bio-physically plausible visualization of highly scattering fluorescent neocortical models for in silico experimentation

Henry Markram, Felix Schürmann, Marwan Muhammad Ahmed Abdellah, Julian Charles Shillcock, Stefan Eilemann, Ahmet Bilgili

Background: We present a visualization pipeline capable of accurate rendering of highly scattering fluorescent neocortical neuronal models. The pipeline is mainly developed to serve the computational neurobiology community. It allows the scientists to visu ...

2017

Representing stimulus information in an energy metabolism pathway

Henry Markram, Felix Schürmann, Daniel Keller, Jay Coggan

We explored a computational model of astrocytic energy metabolism and demonstrated the theoretical plausibility that this type of pathway might be capable of coding information about stimuli in addition to its known functions in cellular energy and carbon ...

2022

Carbon nanotubes might improve neuronal performance by favouring electrical shortcuts

Henry Markram, Michele Giugliano

Carbon nanotubes have been applied in several areas of nerve tissue engineering to probe and augment cell behaviour, to label and track subcellular components, and to study the growth and organization of neural networks. Recent reports show that nanotubes ...

Nature Publishing Group2009

General developmental health in the VPA-rat model of autism

Henry Markram, Kamila Markram, Georges Khazen, Mônica Regina Favre

Autism is a neurodevelopmental condition diagnosed by impaired social interaction, abnormal communication and, stereotyped behaviors. While post-mortem and imaging studies have provided good insights into the neurobiological symptomology of autism, animal ...

Frontiers Research Foundation2013

Modeling and simulation of neocortical micro- and mesocircuitry. Part II: Physiology and experimentation

Weina Ji, Henry Markram, Felix Schürmann, Daniel Keller, Eilif Benjamin Muller, Michael Reimann, Werner Alfons Hilda Van Geit, Srikanth Ramaswamy, Matthias Wolf, James Gonzalo King, Alexis Arnaudon, András Ecker, Rajnish Ranjan, Jean-Denis Georges Emile Courcol, Armando Romani, Pramod Shivaji Kumbhar, Judit Planas Carbonell, Giuseppe Chindemi, Michael Emiel Gevaert, Christian Andreas Rössert, Fernando Joaquim Leite Pereira, Omar Awile, Mustafa Anil Tuncel, Daniela Egas Santander, James Bryden Isbister, Natali Barros Zulaica, Samuel Lieven D. Lapere, Sirio Bolaños Puchet, Maria Reva, Genrich Ivaska, Tanguy Pierre Louis Damart, Darshan Mandge, Joni Henrikki Herttuainen, Christoph Pokorny, Elvis Boci, Vishal Sood, Thomas Brice Delemontex, Aleksandra Zuzanna Teska, Polina Litvak, Alexander Dietz, Jorge Blanco Alonso, Gianluca Ficarelli

Cortical dynamics underlie many cognitive processes and emerge from complex multi-scale interactions, which are challenging to study in vivo. Large-scale, biophysically detailed models offer a tool which can complement laboratory approaches. We present a m ...

2024

Supervised Learning With Perceptual Similarity for Multimodal Gene Expression Registration of a Mouse Brain Atlas

Henry Markram, Felix Schürmann, Daniel Keller, Csaba Erö, Huanxiang Lu, Dimitri Bruno Marie Rodarie, Francesco Casalegno, Jan Krepl, Emilie Delattre

The acquisition of high quality maps of gene expression in the rodent brain is of fundamental importance to the neuroscience community. The generation of such datasets relies on registering individual gene expression images to a reference volume, a task en ...

FRONTIERS MEDIA SA2021

In silico voltage-sensitive dye imaging reveals the emergent dynamics of cortical populations

Henry Markram, Eilif Benjamin Muller, Michael Reimann, Marwan Muhammad Ahmed Abdellah, Grigori Chevtchenko, Taylor Howard Newton

Voltage-sensitive dye imaging (VSDI) is a powerful technique for interrogating membrane potential dynamics in assemblies of cortical neurons, but with effective resolution limits that confound interpretation. To address this limitation, we developed an in ...

Nature Research2021

Mapping of morpho-electric features to molecular identity of cortical inhibitory neurons

Henry Markram, Daniel Keller, Michael Reimann, Srikanth Ramaswamy, Dimitri Bruno Marie Rodarie, Tanguy Pierre Louis Damart, Yann Roussel, Csaba Verasztó

Author summaryThe computational abilities of the brain arise from its organization principles at the cellular level. One of these principles is the neuronal type composition over different regions. Since computational functions of neurons are best describe ...

2023

Inferring connection proximity in networks of electrically coupled cells by subthreshold frequency response analysis

Henry Markram, Michele Giugliano, Corrado Cali

Electrical synapses continuously transfer signals bi-directionally from one cell to another, directly or indirectly via intermediate cells. Electrical synapses are common in many brain structures such as the inferior olive, the subcoeruleus nucleus and the ...

Springer US2008

Impact of higher order network structure on emergent cortical activity

Henry Markram, Michael Reimann, Max Christian Nolte

Synaptic connectivity between neocortical neurons is highly structured. The network structure of synaptic connectivity includes first-order properties that can be described by pairwise statistics, such as strengths of connections between different neuron t ...

2020

The intense world syndrome – an alternative hypothesis for autism

Henry Markram, Kamila Markram, Tania Rinaldi

Autism is a devastating neurodevelopmental disorder with a polygenetic predisposition that seems to be triggered by multiple environmental factors during embryonic and/or early postnatal life. While significant advances have been made in identifying the ne ...

2007

Combinatorial expression rules of ion channel genes in juvenile rat (Rattus norvegicus) neocortical neurons

Henry Markram, Felix Schürmann, Georges Khazen

The electrical diversity of neurons arises from the expression of different combinations of ion channels. The gene expression rules governing these combinations are not known. We examined the expression of twenty-six ion channel genes in a broad range of s ...

Public Library of Science2012

Statistical connectivity provides a sufficient foundation for specific functional connectivity in neocortical neural microcircuits

Henry Markram, Felix Schürmann

It is well-established that synapse formation involves highly selective chemospecific mechanisms, but how neuron arbors are positioned before synapse formation remains unclear. Using 3D reconstructions of 298 neocortical cells of different types (including ...

Natl Acad Sciences2012

The intense world theory - a unifying theory of the neurobiology of autism

Henry Markram, Kamila Markram

Autism covers a wide spectrum of disorders for which there are many views, hypotheses and theories. Here we propose a unifying theory of autism, the Intense World Theory. The proposed neuropathology is hyper-functioning of local neural microcircuits, best ...

2010