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Paul Joseph Dyson

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Publications associées (669)

Systematic design of a targeted organometallic antitumor drug in pre-clinical development

Paul Joseph Dyson

Organometallic ruthenium compds. that are effective anticancer and antimetastasis agents are currently under intensive investigation (see also the article by Peter Sadler in this issue). This article provides a personal account of the way in which we have ...

2007

High-pressure effects on the Diels-Alder reaction in room temperature ionic liquids

Gabor Laurenczy, Paul Joseph Dyson, Ana Vidis

The effect of pressure on the Diels-Alder reaction was examined in room temperature ionic liquids, followed by high-pressure FT-IR spectroscopy using pressures up to 150 MPa. Pressure enhances the kinetic sensitivity of the reaction. The kinetic effec ...

2007

Palladium-Catalyzed Desulfitative Mizoroki-Heck Coupling Reactions of Sulfonyl Chlorides with Olefins in a Nitrile-functionalized Ionic Liquid

Pierre Vogel, Paul Joseph Dyson, Dongbin Zhao, Zhaofu Fei, Chandra Mouleeswara Rao Volla

Aryl and alkenyl sulfonyl chlorides can be used in Heck-Mizoroki-type couplings with mono- and disubstituted olefins in a nitrile-functionalized ionic liquid, viz. [C3CNpy][Tf2N]. Advantages over previously reported methods include: (1) use of a cheap cat ...

2006

Synthesis of Imidazolium-Tethered Ruthenium(II)-Arene Complexes and Their Application in Biphasic Catalysis

Gabor Laurenczy, Rosario Scopelliti, Paul Joseph Dyson

Reaction of RuCl3 with 1-[2-(1,4-cyclohexadiene-1-yl)alkyl]-3-methylimidazolium chloride (alkyl = Et, butyl) and 1-[2-(1,4-cyclohexadiene-1-yl)ethyl]-2,3-dimethylimidazolium chloride affords a series of dimeric ruthenium complexes of the type [RuCl2(η6-are ...

2006

A strategy for the synthesis of transition-metal nanoparticles and their transfer between liquid phases

Paul Joseph Dyson, Dongbin Zhao, Zhaofu Fei, Wee Han Ang

Nanoparticles can be stabilized by an ionic liq. polymer (ILP) composed of imidazolium units incorporating a hydrophobic benzyl group. The resulting gold, platinum, and palladium nanoparticles can be efficiently transferred from water to ionic liqs. by exc ...

2006

Dielectric Response of Imidazolium-Based Room-Temperature Ionic Liquids

Corinne Daguenet, Paul Joseph Dyson

We have used microwave dielec. relaxation spectroscopy to study the picosecond dynamics of five low-viscosity, highly conductive room temp. ionic liqs. based on 1-alkyl-3-methylimidazolium cations paired with the bis((trifluoromethyl)sulfonyl)imide anion. ...

2006

The role of cisplatin and NAMI-A plasma-protein interactions in relation to combination therapy

Paul Joseph Dyson, Gianni Sava

The aim of the study is to evaluate the differences of protein binding of NAMI-A, a new ruthenium drug endowed with selective antimetastatic properties, and of cisplatin and to ascertain the possibility to use two drugs based on heavy metals in combination ...

2006

Metal-based antitumour drugs in the post genomic era

Paul Joseph Dyson, Gianni Sava

The discovery of new metal-based antitumor drugs, whether cisplatin derivs. or those based on other metals, has been largely based on cell viability assays (IC50 values) and compds. that bind to DNA. This approach has been applied for more than 30 years du ...

2006

In Vitro Evaluation of Rhodium and Osmium RAPTA Analogues: The Case for Organometallic Anticancer Drugs Not Based on Ruthenium

Gabor Laurenczy, Paul Joseph Dyson, Antoine Dorcier, Wee Han Ang, Andrew Douglas Phillips

Reaction of the dimer [(η5-C5Me5)RhCl(μ2-Cl)]2 with 2 or 4 equiv of the water-soluble phosphine 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane (pta) affords [Rh(η5-C5Me< ...

2006

Ionic solid-state dimers and polymers derived from imidazolium dicarboxylic acids

Rosario Scopelliti, Paul Joseph Dyson, Zhaofu Fei, Wee Han Ang

A series of imidazolium dicarboxylic acids have been prepd. from the reaction of the 1,3-bis(carboxymethyl)imidazolium zwitterion with the Bronsted acids HX (X = F, Br, Cl, ClO4). The structures of these acids have been established in the solid ...

2006

Influence of Hydrogen-Bonding Substituents on the Cytotoxicity of RAPTA Compounds

Sébastien Rochat, Paul Joseph Dyson, Ursula Röthlisberger, Ivano Tavernelli, Antoine Dorcier, Christian Gossens, Claudine Scolaro, Gianni Sava

A new series of organometallic ruthenium(II)-arene compounds of the type RuCl2(η6-arene)(phosphine) (phosphine = 1,3,5-triaza-7-phosphaadamantane, PTA, and 3,7-diacetly-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane, DAPTA) with different ...

2006

Why Are Ionic Liquids Liquid? A Simple Explanation Based on Lattice and Solvation Energies

Corinne Daguenet, Paul Joseph Dyson

We have developed a simple and quant. explanation for the relatively low melting temps. of ionic liqs. (ILs). The basic concept was to assess the Gibbs free energy of fusion (ΔfusG) for the process IL(s) -> IL(l), which relates to the m.p. ...

2006

One-Step Conversion of Cellobiose to C6-Alcohols Using a Ruthenium Nanocluster Catalyst

Paul Joseph Dyson, Ning Yan, Huizhen Liu, Cheng Zhao

The one-step conversion of cellulose to C6-alcs. via green and energy efficient approaches has, as far as we are aware, not been reported. Such a process presents a considerable challenge, the two key problems being (1) finding a suitable solvent that diss ...

2006

Remarkable Anion and Cation Effects on Stille Reactions in Functionalised Ionic Liquids

Paul Joseph Dyson, Dongbin Zhao, Zhaofu Fei, Cinzia Chiappe

Task-specific ionic liquids bearing nitrile functional groups attached to the cation and nitrogen-donor-containing anions strongly affect the efficiency of the Stille cross-coupling, influencing the nature of the catalyst and its stability. The relative st ...

Wiley2006

1H, 19F-HOESY and PGSE diffusion studies on ionic liquids: The effect of co-solvent on structure

Paul Joseph Dyson

1H, 19F-HOESY studies on the ionic liq. based on 1-butyl-3-methylimidazolium tetrafluoroborate, [C4C1i.m.]BF4, [C4C1i.m.][N(OTf)2], and, partially, [C4C1i.m.]PF6, are reported. The addn. of methanol separates the ions; however, in dichloromethane soln. the ...

2006

Complexation associated rearrangement of iminobiphosphines to diphosphinoamines

Rosario Scopelliti, Paul Joseph Dyson, Dongbin Zhao, Zhaofu Fei, Wee Han Ang

The reaction of the iminobiphosphines RN[dbnd]>PPh2-PPh2, where R = C6H4(p-CN), C6H4(m-CN), C6H4(o-C6H5), C6F5 or C6

2006

Energy-dependent Electrospray Ionisation Mass Spectrometry of Carbonyl Clusters

Paul Joseph Dyson

The electrospray ionisation mass spectra (EDESI-MS) of Ru6C(CO)16(PPh3) and Ir4(CO)11(PR3) (PR3 = PPh3, P(p-C6H4OMe)3, P(p-C6

2006

Synthesis, Characterization, and in Vitro Evaluation of Novel Ruthenium(II) η6-Arene Imidazole Complexes

Rosario Scopelliti, Paul Joseph Dyson, Claudine Scolaro, Andrew Douglas Phillips, Gianni Sava

Ten complexes of general formula [Ru(η6-arene)Cl2(L)], [Ru(η6-arene)Cl(L)2][X], and [Ru(η6-arene)(L)3][X]2 (η6-arene = benzene, p-cymene; L = imidazole, ...

2006

Development of Organometallic Ruthenium-Arene Anticancer Drugs That Resist Hydrolysis

Rosario Scopelliti, Paul Joseph Dyson, Elisa Daldini, Claudine Scolaro, Wee Han Ang

With a view to develop drugs that could resist hydrolysis in aq. media,organometallic arene-capped ruthenium(II) 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane (RAPTA) complexes bearing chelating carboxylate ligands have been prepd. and studied. The new com ...

2006

Metal-Organic Frameworks Derived from Imidazolium Dicarboxylates and Group I and II Salts

Rosario Scopelliti, Paul Joseph Dyson, Zhaofu Fei

A series of coordination polymers contg. Group I or II metal ions, connected via an imidazolium-centered dicarboxylate ligand, have been isolated from water and characterized by single crystal X-ray diffraction. All the structures incorporate water mols. t ...

2006

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