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Paul Joseph Dyson

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Publications associées (669)

Linked Metal-cluster Systems: Isolation and Characterization of {anti-[(p-cymene)RuCl]-m-[k 2-P,P';k 1-P''-(PPh2CH2)3CMe]-[AuPt3(CO)3(PCy3)3]}(PF6)2

Hisham Ben Hamidane, Zoltan Beni, Rosario Scopelliti, Paul Joseph Dyson, Andrew Douglas Phillips, Christian Hartinger

The new mixed-metal complex {anti-[(p-cymene)RuCl]-m-[k 2-P,P';k 1-P''-(PPh2CH2)3CMe]-[AuCl]}PF6 and its cluster deriv. {anti-[(p-cymene)RuCl]-m-[k 2-P,P';k 1-P''-(PPh2CH2)3CMe]-[AuPt3(CO)3(PCy3)3]}(PF6)2 have been prepd. and characterized. Notably, NMR sp ...

Springer US2008

In vitro anticancer activity and biologically relevant metabolization of organometallic ruthenium complexes with carbohydrate-based ligands

Paul Joseph Dyson, Christian Hartinger, Alexey Nazarov, Michael Groessl, Olivier Pierre Zava, Muhammad Hanif, Frédéric Schmitt

The synthesis and in vitro anticancer activity of dihalo(η6-p-cymene)(3,5,6-bicyclophosphite-α-D-glucofuranoside)ruthenium(II) complexes are described. The compds. were characterized by NMR spectroscopy and ESI mass spectrometry, and the mol. structures of ...

2008

Aqueous-phase biphasic dehydroaromatization of bio-derived limonene into p-cymene by soluble Pd nanocluster catalysts

Paul Joseph Dyson, Weijia Gan, Chenxu Zhao

A biphasic approach to the dehydroaromatization of bioderived limonene into water-insol. p-cymene using sol. Pd nanoparticle catalysts in an aq. phase (³150 °C, 2 bar H2) was successfully achieved with a conversion of 93% and a selectivity of 82%. The Pd n ...

2008

Characterization of Platinum Anticancer Drug Protein-Binding Sites Using a Top-Down Mass Spectrometric Approach

Paul Joseph Dyson, Yury Tsybin, Christian Hartinger

A proof-of-principle study on the application of a top-down electrospray ionization Fourier transform ion cyclotron resonance mass spectrometric approach for characterization of the primary binding sites of the platinum anticancer agents cisplatin, transpl ...

2008

Carbohydrate-metal complexes and their potential as anticancer agents

Paul Joseph Dyson, Christian Hartinger, Alexey Nazarov

A review. Platinum complex-based chemotherapy is one of the major treatment options of many malignancies. Although severe side effects occur, and only a limited spectrum of tumors can be cured, Pt compds. are used in every second therapy scheme. Thus, many ...

2008

(Pentamethylcyclopentadienyl)iridium-PTA (PTA = 1,3,5-Triaza-7-phosphaadamantane) Complexes and Their Application in Catalytic Water Phase Carbon Dioxide Hydrogenation

Gabor Laurenczy, Paul Joseph Dyson, Andrew Douglas Phillips

The water-soluble iridium(III) complexes [CpIr(PTA)Cl2] (1) and [CpIr(PTA)2Cl]Cl (2) (PTA = 1,3,5-triaza-7-phosphaadamantane) have been synthesised and characterised by spectroscopy and X-ray crystallography. The complexes were evaluated as catalyst prec ...

2008

The "complex-in-a-complex" cations [(acac)2M.cntnd.Ru6-(p-iPrC6H4Me)6(tpt)2(dhbq)3]6+: a trojan horse for cancer cells

Paul Joseph Dyson, Anna Katherine Renfrew

The cytotoxicities of the large cationic arene-ruthenium prismatic cage [Ru6(p-iPrC6H4Me)6(tpt)2(dhbq)3]6+ (tpt = 2,4,6-tris(pyridin-4-yl)-1,3,5-triazine, dhbq = 2,5-dihydroxy-1,4-benzoquinolato; 16+), and its "complex-in-a-complex" derivs. [(acac)2M-1]6+ ...

Wiley-VCH Verlag GmbH2008

Ruthenium Porphyrin Compounds for Photodynamic Therapy of Cancer

Paul Joseph Dyson, Wee Han Ang, Frédéric Schmitt

Five 5,10,15,20-tetra(4-pyridyl)porphyrin (TPP) areneruthenium(II) derivs., a p-cymeneosmium, a pentamethylcyclopentadienyliridium and a pentamethylcyclopentadienylrhodium analog were prepd. and characterized as potential photosensitizing chemotherapeutic ...

2008

Modulation of the metastatic progression of breast cancer with an organometallic ruthenium compound

Paul Joseph Dyson, Gianni Sava

The modulation of the metastatic progression of breast cancer has been evaluated in vitro and in vivo with RAPTA-T, [Ru(η6-toluene)Cl2(PTA)], an organometallic ruthenium compd. In vitro RAPTA-T inhibits some steps of the metastatic process such as the deta ...

2008

The ruthenium(II)-arene compound RAPTA-C induces apoptosis in EAC cells through mitochondrial and p53-JNK pathways

Paul Joseph Dyson, Christian Hartinger

An investigation of the mol. mechanism of the anticancer activity demonstrated by the ruthenium(II)-arene compd. [Ru(η6-p-cymene)Cl2(pta)] (pta is 1,3,5-triaza-7-phosphaadamantane), termed "RAPTA-C", in Ehrlich ascites carcinoma (EAC) bearing mice is descr ...

2008

How to predict the physical properties of ionic liquids: a volume-based approach

Corinne Daguenet, Paul Joseph Dyson

The mol. vol. Vm (i.e., the sum of the ionic vols. Vion of the constituent ions) of an ionic liq. (IL) in combination with an anion-dependent empirical relationship is all one needs to predict phys. properties such as viscosity, cond., and d. of [N(CN)2]-, ...

Wiley-VCH Verlag GmbH2007

pKa Estimation of Ruthenium(II)-Arene PTA Complexes and their Hydrolysis Products via a DFT/Continuum Electrostatics Approach

Paul Joseph Dyson, Ursula Röthlisberger, Antoine Dorcier, Christian Gossens

A combined d. functional theory/continuum electrostatics approach was used to est. the pKa values of metal-based compds. and their hydrolysis products. Specifically, the protonation states and abs. pKa values of [M(h6-arene)(X)(Y)(pta)]n+ (M = Ru or Os; ar ...

2007

Application of Density Functional Theory and Vibrational Spectroscopy Toward the Rational Design of Ionic Liquids

Paul Joseph Dyson, Ana Vidis

D. functional theory methods in combination with vibrational spectroscopy are used to investigate possible variants of mol. structure of the ion pairs of several imidazolium-based ionic liqs. (ILs). Multiple stable structures are detd. with the anion posit ...

2007

Cytotoxicity of ionic liquids and precursor compounds towards human cell line HeLa

Paul Joseph Dyson, Zhaofu Fei, Xunhui Wang

The toxicity of ethyl-, butyl-, octyl-, benzyl-, and allyl-substituted 1-alkyl-3-methylimidazolium, alkylpyridinium, N-alkyl-N,N-dimethyl-N-(2-hydroxyethyl)ammonium (choline derivs.) and alkyl-triethylammonium salts towards HeLa cells has been studied. The ...

2007

A Metallacage Encapsulating Chloride as a Probe for a Solvation Scale in Ionic Liquids

Corinne Daguenet, Paul Joseph Dyson

With the purpose of assessing the reactivity of chloride ions dissolved in ionic liquids (ILs), a relative scale for the solvation of chloride is given for a series of ILs based on the bis(trifluoromethane)sulfonimide ([Tf2N]) anion and differen ...

2007

Synthesis and crystallographic characterisation of the heterodimetallic complex [(dibenzo-18-crown-6)K(m-Cl)3Ru(h6-p-cymene)]

Rosario Scopelliti, Paul Joseph Dyson

The triple-chlorido-bridged heterodimetallic dinuclear complex [(dibenzo-18-crown-6)K(m-Cl)3Ru(h6-p-cymene)] contg. an (h6-arene)RuII fragment and a Group 1 metal crown ether fragment was synthesized and characterized by spectroscopy and X-ray crystallog. ...

2007

Tuning the hydrophobicity of ruthenium(II)-arene (RAPTA) drugs to modify uptake, biomolecular interactions and efficacy

Paul Joseph Dyson, Claudine Scolaro, Christian Hartinger, Gianni Sava

The antitumor activity of the organometallic ruthenium(II)-arene mixed phosphine complexes, [Ru(h6-p-cymene)Cl(PTA)(PPh3)]BF4 1b and [Ru(h6-C6H5CH2CH2OH)Cl(PTA)(PPh3)]BF4 2b (PTA = 1,3,5-triaza-7-phosphaadamantane), have been evaluated in vitro and compare ...

2007

Transition metal complexes for inhibiting resistance in the treatment of cancer and metastasis

Paul Joseph Dyson, Wee Han Ang

The present invention relates to organometallic compounds useful in the treatment of metastasis. The organometallic compounds comprise a ligand that is convalently bound to a bioactive compound, which is an inhibitor of a resistance pathway or a derivative ...

2007

Improved synthesis of the [Ru(eta(6)-p-cymene)Cl3] anion: facile isolation under mild conditions

Paul Joseph Dyson

Reaction of [Ru(η6-p-cymene)Cl2]2 with two equivalents of [Ph4P][Cl] in CH2Cl2 yields [Ph4P][Ru(η6-p-cymene)Cl3], containing a trichlororuthenate(II) anion. ...

2007

Mass spectrometric analysis of ubiquitin-platinum interactions of leading anticancer drugs: MALDI versus ESI

Paul Joseph Dyson, Wee Han Ang, Christian Hartinger, Angela Casini

The protein binding of anticancer metallodrugs is regarded as an important part in their mode of action both for delivering the active moiety into the tumor but also being responsible for deactivation and/or unwanted side effects. Characterization of prote ...

2007

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