Luc Patiny

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Publications associées (32)

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Aom(2)S: A new web-based application for DNA/RNA tandem mass spectrometry data interpretation

Francisco Sepulveda, Paul Joseph Dyson, Natalia Gasilova, Laure Menin, Luc Patiny, Daniel Ortiz Trujillo

Rationale The Analysis of Oligonucleotide Modifications from Mass Spectra (Aom(2)S) was created to support the analysis of oligonucleotide mass spectra. This application complements the existing software tools by providing a comprehensive analysis of oligo ...

WILEY2020

Versatile Tool for the Analysis of Metal-Protein Interactions Reveals the Promiscuity of Metallodrug-Protein Interactions

Paul Joseph Dyson, Laure Menin, Luc Patiny

Metallodrug protein interactions contribute to their therapeutic effect (even when DNA is the dominant target), side-effects and are implicit in drug resistance. Here, we provide mass spectrometric-based evidence to show that metallodrug interactions with ...

2017

Simultaneous mass spectrometry analysis of cisplatin with oligonucleotide-peptide mixtures: implications for the mechanism of action

Paul Joseph Dyson, Laure Menin, Luc Patiny, Daniel Ortiz Trujillo

Although genomic DNA is the primary target of anticancer platinum-based drugs, interactions with proteins also play a significant role in their overall activity. In this study, competitive binding of cisplatin with an oligonucleotide and two peptides corre ...

SPRINGER2022

Wikipedia Chemical Structure Explorer: substructure and similarity searching of molecules from Wikipedia

Luc Patiny, Michaël Giuseppe Zasso

Background: Wikipedia, the world's largest and most popular encyclopedia is an indispensable source of chemistry information. It contains among others also entries for over 15,000 chemicals including metabolites, drugs, agrochemicals and industrial chemica ...

Biomed Central Ltd2015

ChemCalc: a building block for tomorrow’s chemical infrastructure

Luc Patiny, Alain Borel

Web services, as an aspect of cloud computing, are becoming an important part of the general IT infrastructure, and scientific computing is no exception to this trend. We propose a simple approach to develop chemical web services, through which servers cou ...

2013

Biochemical and biophysical characterization of ruthenation of BRCA1 RING protein by RAPTA complexes and its E3 ubiquitin ligase activity

Paul Joseph Dyson, Laure Menin, Luc Patiny

RAPTA compounds, ([Ru(eta(6)-arene)(PTA)Cl-2], PTA = 1,3,5-triaza-7-phosphaadamantane), have been reported to overcome drug resistance in cisplatin resistant cells. However, the exact mechanism of these complexes is still largely unexplored. In this study, ...

Elsevier2017

Two Decades of Online Teaching: Trends, Challenges, and Future Directions

Luc Patiny

Over the past two decades, significant advancements in educational technology have revolutionized the field of chemical education. This publication presents our contributions using web-based tools that have been developed over this period, enabling chemist ...

2023

The C6H6 NMR repository: An integral solution to control the flow of your data from the magnet to the public

Norman Pellet, Luc Patiny

2018

Fully automatic assignment of small molecules' NMR spectra without relying on chemical shift predictions

Luc Patiny, Julien Wist

We present a method for the automatic assignment of small molecules' NMR spectra. The method includes an automatic and novel self-consistent peak-picking routine that validates NMR peaks in each spectrum against peaks in the same or other spectra that are ...

Wiley-Blackwell2015

Antimalarial and antitubercular nostocarboline and eudistomin derivatives: synthesis, in vitro and in vivo biological evaluation

Rosario Scopelliti, Stewart Cole, Karl Gademann, Luc Patiny

The synthesis of nine nostocarboline derivatives with substitutions of the 2-methyl group by alkyl, aryl and functionalized residues, 10 symmetrical bis cationic dimers linking 6-Cl-norharmane through the 2-position and fifteen derivatives of the marine al ...

2010

Fast and shift-insensitive similarity comparisons of NMR using a tree-representation of spectra

Luc Patiny, Julien Wist

An efficient method to extract and store information from NMR spectra is proposed that is suitable for comparison and construction of a search engine. This method based on trees doesn't require any peak picking or any pre-treatment of the data and is found ...

Elsevier Science Bv2013

Teaching NMR spectra analysis with nmr.cheminfo.org

Luc Patiny

2018