Recherche

Afficher tous les résultats pour

Accueil

Personne

Sandrine Gerber

À propos
Confidentialité
Mentions légales

Graph Chatbot

Publications associées (98)

Convenient synthesis of heterobifunctional poly(ethylene glycol) suitable for the functionalization of iron oxide nanoparticles for biomedical applications

Sandrine Gerber, Luigi Bonacina, Phally Kong, Solène Marcelle Françoise Marie Passemard, Davide Städler

A straightforward route is proposed for the multi-gram scale synthesis of heterobifunctional poly(ethylene glycol) (PEG) oligomers containing combination of triethyloxysilane extremity for surface modification of metal oxides and amino or azido active end ...

Elsevier2013

Surface Modification of Biomaterials for Conjugation with Human Fetal Osteoblasts

Sandrine Gerber, Phally Kong, Françoise Borcard, Céline Marie Anne Journot, Davide Städler

Surface functionalization of hydroxyapatite (HA) and β-tricalcium phosphate (TCP) bioceramics with chemical ligands containing a pyrrogallol moiety was developed to improve the adhesion of bone cell precursors to the biomaterials. Fast and biocompatible co ...

Swiss Chemical Soc2013

Synthesis of bone-like structured foams

Sandrine Gerber, Françoise Borcard

Here we present a processing route to produce multi-structured ceramic foams based on the combination of particle-stabilized foams with polymeric sponges to produce positive and negative templating structures. Polyester sponges are infiltrated with freshly ...

Elsevier Sci Ltd2013

Lack of Enantioselectivity in the SULT1A3-catalyzed Sulfoconjugation of Normetanephrine Enantiomers: An In Vitro and Computational Study

Sandrine Gerber, Jean-Baptiste Gualtierotti

(1R)-Normetanephrine is the natural stereoisomeric substrate for sulfotransferase 1A3 (SULT1A3)-catalyzed sulfonation. Nothing appears known on the enantioselectivity of the reaction despite its potential significance in the metabolism of adrenergic amines ...

Wiley-Blackwell2013

Surface Functionalisation of Alumina Ceramic Foams with Organic Ligands

Sandrine Gerber, Vincent Laporte, Françoise Borcard, Pascal Miéville, Marc Anthony Caporini

Different anchoring groups have been studied with the aim of covalently binding organic linkers to the surface of alumina ceramic foams. The results suggested that a higher degree of functionalisation was achieved with a pyrogallol derivative - as compared ...

2012

Chemical functionalization of bio-ceramics to enhance endothelial cells adhesion for tissue engineering

Sandrine Gerber, Françoise Borcard, Davide Städler

To control the selective adhesion of human endothelial cells and human serum proteins to bioceramics of different compositions, a multifunctional ligand containing a cyclic arginine-glycine-aspartate (RGD) peptide, a tetraethylene glycol spacer, and a gall ...

American Chemical Society2012

Functionalization of microstructured open-porous bio-ceramic scaffolds with human fetal cells

Sandrine Gerber, Corinne Scaletta, Françoise Borcard, Davide Städler

Bone substitute materials allowing trans-scaffold migration and in-scaffold survival of human bone-derived cells are mandatory for development of cell-engineered permanent implants to repair bone defects. In this study, we evaluated the influence on human ...

American Chemical Society2012

Harmonic Nanocrystals for Bio-Labeling: a Survey of Optical Properties and Biocompatibility

Daniel Rytz, Jean-Pierre Wolf, Sandrine Gerber, Rachid Hadji, Luigi Bonacina, Solène Marcelle Françoise Marie Passemard, Davide Städler, Jérôme Extermann

Nonlinear optical nanocrystals have been recently introduced as a promising alternative to fluorescent probes for multi-photon microscopy. We present for the first time a complete survey of the properties of the different nanomaterials proposed to date, de ...

American Chemical Society2012

Synthetic calibrators for the analysis of sulfoconjugated metanephrines in urine: hydrolysis conditions revisited

Sandrine Gerber, Jonathan Simonin

Background: The quantification of total (free + sulfated) metanephrines in urine is recommended to diagnose pheochromocytoma. Urinary metanephrines include metanephrine itself, normetanephrine and methoxytyramine, mainly in the form of sulfate conjugates ( ...

Elsevier2012

Covalent cell surface functionalization of human fetal osteoblasts for tissue engineering

Sandrine Gerber, Aurélien Godinat, Corinne Scaletta, Françoise Borcard, Davide Städler

The chemical functionalization of cell-surface proteins of human primary fetal bone cells with hydrophilic bioorthogonal intermediates was investigated. Toward this goal, chemical pathways were developed for click reaction-mediated coupling of alkyne deriv ...

2011

Synthesis and Biological Evaluation of Modified 2-Deoxystreptamine Dimers

Sandrine Gerber, Inmaculada Robina, Gérald Coste

Aminoglycosides are powerful antibiotics, but the emergence of resistant bacterial strains has prompted the search for analogues with better pharmacological profiles. The synthesis of 2-deoxystreptamine (2-DOS) dimers linked by polyamines and analogues bas ...

2011

A spinning thermometer to monitor microwave heating and glass transitions in dynamic nuclear polarization

Geoffrey Bodenhausen, Sandrine Gerber, Sami Jannin, Pascal Miéville, Marc Anthony Caporini

As previously demonstrated by Thurber and Tycko, the peak position of Br-79 in potassium bromide (KBr) allows one to determine the temperature of a spinning sample. We propose to adapt the original design by using a compact KBr tablet placed at the bottom ...

Wiley-Blackwell2011

Fractional Spin-Labeling of Polymers for Enhancing NMR Sensitivity by Solvent-Free Dynamic Nuclear Polarization

Andrzej Sienkiewicz, Geoffrey Bodenhausen, Sandrine Gerber, Sami Jannin, Françoise Borcard, Pascal Miéville, Marc Anthony Caporini

Wiley-Blackwell2011

Observations of Pauli paramagnetic effects on the flux line lattice in CeCoIn5

Sandrine Gerber, Joël Mesot, Jonathan White, Pratyush Das

From small-angle neutron scattering studies of the flux line lattice (FLL) in CeCoIn5, with magnetic field applied parallel to the crystal c-axis, we obtain the field and temperature dependence of the FLL form factor (FF), which is a measure of the spatial ...

2010

Synthetic studies toward the CD spiroketal of spongistatins

Pierre Vogel, Sandrine Gerber, Sylvain Favre

Starting from the readily available meso-methylenedi(8-oxa-3-oxobicyclo[3.2.1]hept-6-en-1-yl) (1), meso-1,1'-methylidene [(4R,4'S,6R,6'S)-4,6-dioxycyclohept-1-en-1-yl]tetrasilylethers (7, 8) were obtained and transformed into all-syn 1,3,5,11,13,15-hexahyd ...

Wiley-Blackwell2010

Scavenging Free Radicals To Preserve Enhancement and Extend Relaxation Times in NMR using Dynamic Nuclear Polarization

Arnaud Comment, Geoffrey Bodenhausen, Sandrine Gerber, Rolf Gruetter, Sami Jannin, Riddhiman Sarkar, Paul Romeo Vasos, Puneet Ahuja, Pascal Miéville, Mor-Miri Mishkovsky

Vitamin C for longer lifetimes: N-oxide radicals that are widely used for dynamic nuclear polarization can be reduced by scavengers such as sodium ascorbate (vitamin C) during the dissolution process, thus diminishing losses of polarization during the tran ...

Wiley-Blackwell2010

Inhibitors of prolyl-oligopeptidases for the therapy of human diseases: defining diseases and inhibitors

Sandrine Gerber

American Chemical Society2010

Studies toward new anti-cancer strategies based on alpha-mannosidase inhibition

Sandrine Gerber

Changes in the glycosylation pattern of cellular glycoproteins constitute a hallmark in human cancer and influence tumour progression, suggesting that inhibitors of selected glycosidases may control cancer invasion. Following the studies on swainsonine, a ...

Schweizerische Chemische Gesellschaft2010

A Short and Convenient Synthesis of 1-Deoxymannojirimycin (DMJ) and N-oxy-Analogues from D-Fructose

Pierre Vogel, Sandrine Gerber, Claudia Bello

The ketonitrone 8 was prepared from D-fructose as an inexpensive starting material, and was used in a stereoselective synthesis of 1-deoxymannojirimycin (4), its previously unknown N-hydroxy analogue 15, as well as the polyhydroxylated ketonitrone 14. The ...

2009

The prolyl-aminodipeptidases and their inhibitors as therapeutic targets for fibrogenic disorders

Sandrine Gerber

Many biologically active peptides are protected from general proteolytic degradation by evolutionary conserved prolines (Pro), due to conformational constraints imposed by the Pro residue. Thus the biological importance of prolyl-specific peptidases points ...

2009

Page 4 sur 5