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Kay Severin

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Publications associées (216)

Beyond Click-Chemistry: Transformation of Azides with Cyclopentadienyl Ruthenium Complexes

Kay Severin, Rosario Scopelliti, Julie Risse

The cyclopentadienyl Ru complexes CpRuCl(cod) (cod = 1,5-cyclooctadiene), CpRuCl(PPh3)2, and [CpRuCl2]2 (Cp = η5-1-methoxy-2,4-di-tert-butyl-3-neopentylcyclopentadienyl) are able to catalyze the decomposition of benzyl azides to give 1,3,5-triphenyl-2,4- ...

American Chemical Society2011

Dative boron–nitrogen bonds in structural supramolecular chemistry: multicomponent assembly of prismatic organic cages

Kay Severin, Rosario Scopelliti, Kurt Schenk, Burçak Içli, Erin Sheepwash

The multicomponent reaction of diboronic acids with a catechol and a tripyridyl linker results in the formation trigonal prismatic cages. The cages feature six dative boron–nitrogen bonds as structure-directing elements. The size of the cages can be varied ...

2011

A molecular probe for the optical detection of biogenic amines

Kay Severin, Rosario Scopelliti, Bo Ram Lee

A coumarin derivative was employed for the detection of biogenic amines in buffered aqueous solution by UV-Vis or fluorescence spectroscopy. Incorporated in a polymeric matrix, the dye can also be used for the optical detection of gaseous amines. ...

Royal Society of Chemistry2011

Carbohydrate sensing with a metal-based indicator displacement assay

Kay Severin, Vera Janowski

A Pd-based indicator displacement assay for the fluorimetric sensing of carbohydrates has been developed. The assay allows the detection of saccharides in the low millimolar concentration range in water at neutral pH. ...

Royal Society of Chemistry2011

A Fluorescent Sensor for Pyrophosphate Based on a Pd(II) Complex

Kay Severin, Rosario Scopelliti, Jie Gao

A mixture of the Pd(II) complex [Pd(NO3)2(bipy)] (bipy = 2,2-bipyridine) and the fluorescent dye Methylcalcein blue (MCB) constitutes a chemosensing ensemble which can be used for the detection of pyrophosphate (PPi) by fluorescence spectroscopy. The senso ...

Royal Society of Chemistry2010

Reactions of Alkynes with [RuCl(cyclopentadienyl)] Complexes: The Important First Steps

Kay Severin, Rosario Scopelliti, Euro Solari, Ursula Röthlisberger, Basile Curchod, Barnali Dutta, Pablo Campomanes Ramos

Cyclopentadienyl-ruthenium half-sandwich complexes with 2-bound alkyne ligands have been suggested as catalytic intermediates in the early stages of Ru-catalyzed reactions with alkynes. We show that electronically unsaturated complexes of the formula [RuCl ...

2010

Fluorescence Sensors for Lithium Ions and Small Peptides

Kay Severin, Sébastien Rochat

Simple but powerful chemosensors were developed by taking advantage of self-assembly processes. First, we will describe a turn-on fluorescent sensor for the pharmacologically important lithium ion. The sensor can be used in purely aqueous solution, and it ...

Schweizerische Chemische Gesellschaft2010

Combining Metallasupramolecular Chemistry with Dynamic Covalent Chemistry: Synthesis of Large Molecular Cages

Kay Severin, Rosario Scopelliti, Anton Granzhan

Ru-built cube: By combining metallasupramolecular chemistry with dynamic covalent chemistry, complex nanostructures can be formed. Large cages are synthesized by reaction of trinuclear metallamacrocycles containing pendant aldehyde groups. ...

Wiley-VCH Verlag GmbH2010

Pattern-Based Sensing of Sulfated Glycosaminoglycans with a Dynamic Mixture of Iron Complexes

Kay Severin

A dynamic mixture of iron complexes was used as a colorimetric sensor for sulfated glycosaminoglycans. The sensing ensemble was prepared by mixing [FeCl2(H2O)4] with dipicolylamine, the functionalized bipyridyl ligand N-(6-aminohexyl)-4'-methyl-2,2'-bipyri ...

Royal Society of Chemistry2010

A Micelle-Based Chemosensing Ensemble for the Fluorimetric Detection of Chloride in Water

Kay Severin

Caught in a trap! Fluorimetric chloride sensing in water is achieved by exploiting the changes in partition constant of a receptor complex in its bound and nonbound states. In the presence of chloride, the complex preferentially resides in the micelle pseu ...

2010

Pattern-Based Sensing of Short Oligodeoxynucleotides with Palladium–Dye Complexes

Kay Severin, Anton Granzhan, Jie Gao

The colorimetric response of a sensor array composed of palladium–dye complexes can be used to identify different hexadeoxynucleotides and to distinguish mixtures of sequence-isomeric hexadeoxynucleotides. ...

Royal Society of Chemistry2010

Pattern-Based Sensing with Metal−Dye Complexes: Sensor Arrays versus Dynamic Combinatorial Libraries

Kay Severin, Sébastien Rochat

The dyes Methyl Calcein Blue, Arsenazo I, and Xylenol Orange, and the metal salts CuCl2 and NiCl2 were used to generate colorimetric sensors for peptides. Two different approaches were followed: (1) Sensors based on dynamic combinatorial libraries of metal ...

American Chemical Society2010

Cross-Reactive Sensor Arrays for the Detection of Peptides in Aqueous Solution by Fluorescence Spectroscopy

Kay Severin, Sébastien Rochat, Friederike Gundula Marie Zaubitzer, Jie Gao

A simple but powerful method for the sensing of peptides in aqueous solution has been developed. The transition-metal complexes [PdCl2(en)], [{RhCl2Cp*}2], and [{RuCl2(p-cymene)} 2] were combined with six different fluorescent dyes to build a cross-reactiv ...

2010

Atom-Transfer Radical Addition Reactions Catalyzed by RuCp* Complexes: A Mechanistic Study

Andrzej Sienkiewicz, Kay Severin, Katrin Anne Thommes, Katarzyna Pierzchala, Gregor Kiefer

Kinetic and spectroscopic analyses were performed to gain information about the mechanism of atom-transfer radical reactions catalyzed by the complexes [RuCl2Cp*(PPh3)] and [RuClCp*(PPh3)2] (Cp*=pentamethylcyclopentadienyl), in the presence and in the abse ...

2009

Olefin Cyclopropanation by a Sequential Atom-Transfer Radical Addition and Dechlorination in the Presence of a Ruthenium Catalyst

Kay Severin, Rosario Scopelliti, Katrin Anne Thommes, Gregor Kiefer

Wiley-VCH Verlag GmbH2009

Multifaceted Chemistry of [(Cymene)RuCl2]2 and PCy3

Kay Severin, Rosario Scopelliti, Euro Solari, Sébastien Gauthier

The reaction of (cymene)RuCl2 (1) with PCY3 was investigated using different stoichiometries and reaction conditions. Whereas a mixture of complex 1 and 2 equiv of PCy3 in methanol gave the known adduct [(cymene)Rucl(2)(PCy3)] (3) along with the phosp ...

American Chemical Society2009

Boronic Acids as Building Blocks for Molecular Nanostructures and Polymeric Materials

Kay Severin

Boronic acids are versatile building blocks for the construction of complex molecular architectures. Using reversible condensation reactions, it is possible to obtain macrocycles, cages, dendritic structures, and rotaxanes, as well as 1-, 2-, and 3-dimensi ...

2009

Organometallic complexes that interconvert between trimeric and monomeric structures as a function of pH and their effect on human cancer and fibroblast cells

Kay Severin, Rosario Scopelliti, Paul Joseph Dyson, Zacharias Immanuel Grote, Wee Han Ang

Organometallic half-sandwich complexes based on ruthenium with aminomethyl-substituted 3-hydroxy-2-pyridone ligands exist in aqueous solution as monomeric O,O′-chelate complexes or trimeric metallamacrocycles depending upon the pH. We hypothesized that adm ...

2009

Influence of the Arene Ligand, the Number and Type of Metal Centers, and the Leaving Group on the in Vitro Antitumor Activity of Polynuclear Organometallic Compounds

Kay Severin, Christian Hartinger, Alexey Nazarov

Dinuclear ruthenium complexes were shown to exhibit strong antiproliferative properties in human tumor cell lines. In order to extend the structure−activity relationships (SARs), a series of new RuII(arene)X complexes (X = Cl, Br, I) linked by pyridinone-b ...

2009

Synthesis of Molecular Nanostructures by Multicomponent Condensation Reactions in a Ball Mill

Kay Severin, Rosario Scopelliti, Nicolas Christinat, Burçak Içli, Christian Schüttler, Justus Tönnemann

The condensation of multiple building blocks in a ball mill allows molecular cages with a size up to 3.1 nm to be built. ...

2009

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