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Lysianne Follonier Castella

Cette personne a quitté l’EPFL

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Publications associées (4)

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Coordination of Myofibroblast Contraction in Vitro

Lysianne Follonier Castella

The aim of this thesis is to elucidate the common mechanisms that regulate myofibroblast contraction and intercellular communication, with a particular focus on the role of Ca2+ signalling. Synthesis and remodelling of collagenous matrix by myofibroblasts ...

EPFL2010

A New Lock-step Mechanism of Matrix Remodelling Based on Subcellular Contractile Events

Boris Hinz, Jean-Jacques Meister, Lara Buscemi Estefanell, Lysianne Follonier Castella

Myofibroblasts promote tissue contractures during fibrotic diseases. To understand how spontaneous changes in the intracellular calcium concentration, Ca2+, contribute to myofibroblast contraction, we analysed both Ca2+ and subcellular contractio ...

Company of Biologists2010

The Mechanical Environment Modulates Intracellular Calcium Oscillation Activities of Myofibroblasts

Boris Hinz, Adriano Garonna, Lysianne Follonier Castella

Myofibroblast contraction is fundamental in the excessive tissue remodeling that is characteristic of fibrotic tissue contractures. Tissue remodeling during development of fibrosis leads to gradually increasing stiffness of the extracellular matrix. We pro ...

Public Library Science2013

Myofibroblast communication is controlled by intercellular mechanical coupling

Boris Hinz, Jean-Jacques Meister, Sébastien Schaub, Lysianne Follonier Castella

Neoformation of intercellular adherens junctions accompanies the differentiation of fibroblasts into contractile myofibroblasts, a key event during development of fibrosis and in wound healing. We have previously shown that intercellular mechanical couplin ...

Company of Biologists2008