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Ljubisa Miskovic

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Publications associées (35)

Rites of passage: requirements and standards for building kinetic models of metabolic phenotypes

Ljubisa Miskovic, Vassily Hatzimanikatis, Milenko Tokic, Georgios Fengos

The overarching ambition of kinetic metabolic modeling is to capture the dynamic behavior of metabolism to such an extent that systems and synthetic biology strategies can reliably be tested in silico. The lack of kinetic data hampers the development of ki ...

Elsevier2015

Antihypertensive drugs metabolism: an update to pharmacokinetic profiles and computational approaches

Ljubisa Miskovic, Vassily Hatzimanikatis, Aikaterini Zisaki

Drug discovery and development is a high-risk enterprise that requires significant investments in capital, time and scientific expertise. The studies of xenobiotic metabolism remain as one of the main topics in the research and development of drugs, cosmet ...

Bentham Science Publishers2015

Towards kinetic modeling of genome-scale metabolic networks without sacrificing stoichiometric, thermodynamic and physiology constraints

Ljubisa Miskovic, Vassily Hatzimanikatis, Keng Cher Soh, Anirikh Chakrabarti

Mathematical modeling is an essential tool for a comprehensive understanding of cell metabolism and its interactions with the environmental and process conditions. Recent developments in the construction and analysis of stoichiometric models made it possib ...

2013

Production of biofuels and biochemicals: in need of an ORACLE

Ljubisa Miskovic, Vassily Hatzimanikatis

The engineering of cells for the production of fuels and chemicals involves simultaneous optimization of multiple objectives, such as specific productivity, extended substrate range and improved tolerance – all under a great degree of uncertainty. The achi ...

Elsevier2010

Modeling of uncertainties in biochemical reactions

Ljubisa Miskovic, Vassily Hatzimanikatis

Mathematical modeling is an indispensable tool for research and development in biotechnology and bioengineering. The formulation of kinetic models of biochemical networks depends on knowledge of the kinetic properties of the enzymes of the individual react ...

Wiley-Blackwell2010

Quantification of uncertainty in metabolic networks through the sampling of kinetic data space

Ljubisa Miskovic, Vassily Hatzimanikatis

Study of a metabolic network with respect to the sensitivity of the metabolite concentrations and the metabolic fluxes to genetic, biochemical, and environmental variations requires knowledge of the kinetic properties of the enzymes in the network. Experim ...

2009

Closed-loop Identification of Multivariable Systems: With or Without Excitation of All References?

Dominique Bonvin, Ljubisa Miskovic, Alireza Karimi

A variance analysis of the parameters of a plant, belonging to a class of multivariable systems, estimated in closed-loop operation is performed. More specifically, having in mind the control applications where it is not desirable to excite all external re ...

2008

Correlation-Based Tuning of Decoupling Multivariable Controllers

Dominique Bonvin, Ljubisa Miskovic, Alireza Karimi

The iterative data-driven method labelled Correlation-based Tuning (CbT) is considered in this paper for the tuning of linear time-invariant multivariable controllers. The approach allows one to tune some elements of the controller transfer function matrix ...

2007

Direct Closed-Loop Identification of Multi-Input Systems: Variance Analysis

Dominique Bonvin, Ljubisa Miskovic, Alireza Karimi

An analysis of the variance of the parameters of a multi-input plant estimated in closed-loop operation is performed. More specifically, the effect of the simultaneous excitation of an additional input on the variance of the estimated parameters is investi ...

2006

Identification of multi-input systems: variance analysis and input design issues

Dominique Bonvin, Ljubisa Miskovic, Alireza Karimi

This paper examines the identification of multi-input systems. Motivated by an experiment design problem (should one excite the various inputs simultaneously or separately), we examine the effect of an additional input on the variance of the estimated coef ...

2006

Perturbation rejection control strategy for OWL

Babak Sedghi, Ljubisa Miskovic

The control system of the ESO 100 m telescope (OWL) has to reject slow and fast perturbations in several subsystems. In this paper we focus on the wind rejection control strategies for two subsystems: the main axes and the segmented mirror. It is shown tha ...

2006

Data-driven controller tuning using the correlation approach

Ljubisa Miskovic

The essential ingredients of control design procedures include the acquisition of process knowledge and its efficient integration into the controller. In many practical control applications, a reliable mathematical description of the plant is difficult or ...

EPFL2006

On the Input Design for Data-Driven Correlation-Based Tuning of Multivariable Controllers

Dominique Bonvin, Ljubisa Miskovic, Alireza Karimi

An iterative data-driven correlation-based method has been proposed recently to tune multivariable linear time-invariant controllers in closed-loop operation. In this contribution, the preferred way of exciting a 2 × 2 system is investigated via the accura ...

2006

Correlation-Based Tuning of Linear Multivariable Decoupling Controllers

Dominique Bonvin, Ljubisa Miskovic, Alireza Karimi

The recently-proposed method for iterative correlation-based controller tuning is considered in this paper for the tuning of multivariable Linear Time-Invariant (LTI) controllers. The parameters of the controller are updated directly using the data acquire ...

2005

Identification of a Two-Input System: Variance Analysis

Dominique Bonvin, Ljubisa Miskovic, Alireza Karimi

This paper examines the identification of a single-output two-input system. Motivated by an experiment design problem(should one excite the two inputs simultaneously or separately), we examine the effect of the (second) input signal on the variance of the ...

2005

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