Publications de Vincent Stadelmann

Publications associées (15)

Prevention of micromotion-related periprosthetic bone loss using local release of bisphosphonate : theoretical developments and experimental validations

Total joint replacements are highly successful in relieving pain and restoring movement of damaged joints. However, the lifespan of the implants is limited. The implant's long-term stability depends largely on the preservation of periprosthetic bone. Debri ...

EPFL2008

Prediction of bone density around orthopedic implants delivering bisphosphonate

Dominique Pioletti, Alexandre Terrier, Vincent Stadelmann

The fixation of an orthopedic implant depends strongly upon its initial stability. Peri-implant bone may resorb shortly after the surgery. This resorbtion is directly followed by new bone formation and implants fixation strengthening, the so-called seconda ...

2009

Implants delivering bisphosphonate locally increase periprosthetic bone density in an osteoporotic sheep model. A pilot study

Dominique Pioletti, Alexandre Terrier, Vincent Stadelmann

It is a clinical challenge to obtain a sufficient orthopedic implant fixation in weak osteoporotic bone. When the primary implant fixation is poor, micromotions occur at the bone-implant interface, activating osteoclasts, which leads to implant loosening. ...

2008

Microstimulations at the bone implant interface upregulate osteoclast activation pathway

Dominique Pioletti, Alexandre Terrier, Vincent Stadelmann

Peri-implant bone resorption after total joint arthroplasty is a key parameter in aseptic loosening. Implant wear debris and biomechanical aspects have both been demonstrated to be part of the bone resorption process. However, neither of these two paramete ...

2008

The Matricellular Protein Periostin Is Required for Sost Inhibition and the Anabolic Response to Mechanical Loading and Physical Activity

Vincent Stadelmann

Periostin (gene Postn) is a secreted extracellular matrix protein involved in cell recruitment and adhesion and plays an important role in odontogenesis. In bone, periostin is preferentially expressed in the periosteum, but its functional significance rema ...

2009

Injectable calcium phosphate cement for augmentation around cancellous bone screws. In vivo biomechanical studies

Dominique Pioletti, Vincent Stadelmann

In lower cancellous apparent bone density, it can be difficult to achieve adequate screw fixation and hence stable fracture fixation. Different strategies have been proposed, one of them is through augmentation using calcium phosphate cement in the region ...

Elsevier2012

Osteoclastogenesis can be mechanically-induced in the peri-implant bone

Dominique Pioletti, Alexandre Terrier, Vincent Stadelmann

Total joint replacements are highly successful in relieving pain and restoring movement of damaged joints. However, the lifespan of the implants is limited. The implant’s long-term stability depends largely on the preservation of periprosthetic bone. Debri ...

2009

Osteopenia, decreased bone formation and impaired osteoblast development in Sox4 heterozygous mice

Vincent Stadelmann

The transcription factor Sox4 is vital for fetal development, as Sox4–/– homozygotes die in utero. Sox4 mRNA is expressed in the early embryonic growth plate and is regulated by parathyroid hormone, but its function in bone modeling/remodeling is unknown. ...

2007

Calcium phosphate cement augmentation of cancellous bone screws can compensate for the absence of cortical fixation

Dominique Pioletti, Alexandre Terrier, Vincent Stadelmann

An obvious means to improve the fixation of a cancellous bone screw is to augment the surrounding bone with cement. Previous studies have shown that bone augmentation with Calcium Phosphate (CaP) cement significantly improves screw fixation. Nevertheless, ...

Elsevier2010

Combined effects of zoledronate and mechanical stimulation on bone adaptation in an axially loaded mouse tibia

Dominique Pioletti, Vincent Stadelmann

Background: Local bisphosphonate delivery may be a solution to prevent periprosthetic bone loss and improve orthopedic implants fixation. In load-bearing implants, periprosthetic bone is exposed to high mechanical demands, which in normal conditions induce ...

Elsevier2011

3D strain map of axially loaded mouse tibia: a numerical analysis validated by experimental measurements

Dominique Pioletti, Alexandre Terrier, Vincent Stadelmann, Francesco Merlini

A combined experimental/numerical study was performed to calculate the zone of highest strain in a rat tibia loaded axially. This study is motivated by the fact that the bone remodeling analysis in this in vivo rat model should be performed at the zone of ...

2009

3D strain map of axially loaded mouse tibia: a numerical analysis validated by experimental measurements

Dominique Pioletti, Alexandre Terrier, Vincent Stadelmann, Francesco Merlini

A combined experimental/numerical study was performed to calculate the 3D octahedral shear strain map in a mouse tibia loaded axially. This study is motivated by the fact that the bone remodelling analysis, in this in vivo mouse model should be performed a ...

2009

Cellular gradient polymer composites

Jan-Anders Edvin Maansson, Dominique Pioletti, Pierre-Etienne Bourban, Vincent Stadelmann, Manuel Bühler

The invention relates to a foamed polymer composite product incorporating several fillers and/or fibres and several pores characterized by the fact that it shows two distinct gradients, namely a filler and/or fibre density gradient and a pore density gradi ...

2008

Orthopedic implant used as drug delivery system: clinical situation and state of the research

Dominique Pioletti, Vincent Stadelmann

A partial review is proposed on the existing literature for the research performed in orthopedic implant used as drug delivery system. In the first part an evaluation is given on the clinical need to deliver a drug in the surrounding of an implant. Secondl ...

2008

Redesigning commercial total hip replacement instruments: an educational project

Dominique Pioletti, Vincent Stadelmann, Noé Schmutz

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