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Matthieu Philippe Emmanuel Zellweger

Cette personne a quitté l’EPFL

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Publications associées (35)

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Optical spectroscopy of the bladder washout fluid to optimize fluorescence cystoscopy with Hexvix

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Blaise Lovisa, Carla Martoccia

Fluorescence cystoscopy enhances detection of early bladder cancer. Water used to inflate the bladder during the procedure rapidly contains urine, which may contain fluorochromes. This frequently degrades fluorescence images. Samples of bladder washout flu ...

SPIE Society of Photo-optical Instrumentation Engineers2014

Study of the stability of the 5-aminolevulinic acid tyrosine ester in aqueous solution

Qian Wang, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Sandrine Gay, Carla Martoccia

Photodynamic therapy based on photoactivable porphyrins (PAPs) can treat various dermatological conditions. The side-effects as well as the non-selective or insufficient accumulation of PAPs in the targeted tissues limit performances. We studied the stabil ...

2014

Photoeradication of Helicobacter pylori in humans: Phase 1 study

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

1999

Comparison of ALA- and ALA hexyl-ester-induced PpIX depth distribution in human skin carcinoma

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Tanja Gabrecht

Photodynamic therapy (PDT) based on the use of photoactivable porphyrins, such as protoporphyrin IX (PpIX), induced by the topical application of amino-levulinic acid (ALA) or its derivatives, ALA methyl-ester (m-ALA), is a treatment for superficial basal ...

Elsevier2008

Detection of early bronchial cancer by autofluorescence: first clinical results with an improved system

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Thomas Stepinac

2007

Correlations between photoactivable porphyrins’ fluorescence, erythema and the pain induced by PDT on normal skin using ALA-derivatives

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

Summary Background Photodynamic therapy (PDT) with precursors of photoactivable porphyrins is a well-established treatment modality for skin pathologies as well as hair removal. Pain is a major side effect thereof, and it affects the treatment compliance a ...

Elsevier2013

Optimization and characterization of the endogenous production of protoporphyrin IX in a yeast model

Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Jaroslava Joniová, Emmanuel Louis Arthur Gerelli

The availability of reproducible, convenient, and inexpensive model organisms able to generate predictable levels of endogenous porphyrins, including protoporphyrin IX (PpIX), is essential in photomedicine research. Saccharomyces cerevisiae produces endoge ...

SPIE Society of Photo-optical Instrumentation Engineers2016

An optical phantom with tissue-like properties in the visible for use in PDT and fluorescence spectroscopy

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

1997

Solution for diagnosing or treating tissue pathology

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

PROBLEM TO BE SOLVED: To provide a composition for diagnosing and/or treating cancerous pathologies in the field of urology. ;SOLUTION: The invention relates to a 5-aminolevulinic acid ester (E-ALA) solution for producing a pharmaceutical preparation usefu ...

1999

Assessment of a sheep animal model to optimize photodynamic therapy with Foscan in the esophague

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, François André Borle

Precursor lesions of oesophagus adenocarcinoma constitute a clinical dilemma. Photodynamic therapy (PDT) is an effective treatment for this indication, but it is difficult to optimise without an appropriate animal model. For this reason, we assessed the sh ...

Wiley-Blackwell2009

Correlation between Protoporphyrin IX Fluorescence Intensity, Photobleaching, Pain and Clinical Outcome of Actinic Keratosis Treated by Photodynamic Therapy

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

Background: Photodynamic therapy (PDT) with Metvix® is a good therapeutic option to treat actinic keratosis, but it presents drawbacks (pain, lesion recurrences, heterogeneous outcome), emphasizing the possible need to individualize treatment. Objective: W ...

Karger2013

Intra-Arterial Drug and Light Delivery for Photodynamic Therapy Using Visudyne (R): Implication for Atherosclerotic Plaque Treatment

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

Photodynamic therapy (PDT), which is based on the activation of photosensitizers with light, can be used to reduce plaque burden. We hypothesized that intra-arterial photosensitizer administration and photo-activation will lead to high and rapid accumulati ...

2016

Fluorescence pharmacokinetics of Lutetium Texaphyrin (PCI-0123, Lu-Tex) in the skin and in healthy and tumoral hamster cheek-pouch mucosa

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

We have investigated the pharmacokinetics (PK) of Lutetium Texaphyrin (Lu-Tex), a second-generation photosensitizer, in the Syrian hamster cheek pouch early cancer model. Ten male hamsters, five with chem. induced early squamous cell cancer of the left che ...

Elsevier2000

Fluorescence spectroscopy of exogenous, exogenously-induced and endogenous fluorophores for the photodetection and photodynamic therapy of cancer

Matthieu Philippe Emmanuel Zellweger

EPFL2000

Autofluorescence bronchoscopy: Clinical experience with an optimized system in head and neck cancer patients

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Tanja Gabrecht, Blaise Lovisa

Elsevier2007