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Georges Wagnières

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Publications associées (165)

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Light dosimetry for photodynamic therapy in the esophagus

Hubert van den Bergh, Georges Wagnières

BACKGROUND AND OBJECTIVE: Photodynamic therapy (PDT) is an efficient technique to treat superficial early cancers in the pharynx, esophagus, and tracheo-bronchial tree. However, the lack of selectivity of some of the clinically used photosensitizers can re ...

1997

An endoscopic fluorescence imaging system for simultaneous visual examination and photodetection of cancers

Hubert van den Bergh, Georges Wagnières, André Studzinski

We describe the design and performance tested during six years of clinical trials of a fluorescence endoscope for the detection and delineation of cancers in several hollow organs. The apparatus is based on the imaging of the laser-induced fluorescence tha ...

1997

Photodynamic therapy for early squamous cell carcinomas of the esophagus, bronchi, and mouth with m-tetra(hydroxyphenyl) chlorin

Hubert van den Bergh, Georges Wagnières

Objective: To clinically evaluate a new photosensitizer, m- tetra(hydroxyphenyl) chlorin (m-THPC), for the photodynamic therapy of early squamous cell carcinomas of the upper aerodigestive tract. Design: Phase 1 included evaluation of the innocuousness of ...

1997

Determination of the radiance of cylindrical light diffusers: design of a one-axis charge-coupled device camera-based goniometer setup

Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Blaise Lovisa, Andreas Pitzschke

A one-axis charge-coupled device camera-based goniometer setup was developed to measure the three-dimensional radiance profile ( longitudinal, azimuthal, and polar) of cylindrical light diffusers in air and water. An algorithm was programmed to project the ...

SPIE Society of Photo-optical Instrumentation Engineers2017

Interstitial photodynamic therapy with tetra(m-hydroxyphenyl)chlorin: tumor versus striated muscle damage

Hubert van den Bergh, Georges Wagnières

Purpose: The present study was initiated to det. the conditions under which a single photodynamic treatment would induce maximal damage to a tumor with no or at least minimal reversible damage to a normal striated muscle. Methods and Materials: The techniq ...

1998

Measurement of pO2 by luminescence lifetime spectroscopy: A comparative study of the phototoxicity and sensitivity of [Ru(Phen)3]2+ and PdTCPP in vivo

Georges Wagnières, Emmanuel Louis Arthur Gerelli, Veronika Huntosova

Dysfunctions in tissue metabolism can be detected at early stages by oxygen partial pressure (pO(2)) measurement. The measurement of emission lifetimes offers very promising and non-invasive approach to estimate pO(2) in vivo. This study compares two exten ...

Wiley-V C H Verlag Gmbh2016

Optical Characterization of an Intra-Arterial Light and Drug Delivery System for Photodynamic Therapy of Atherosclerotic Plaque

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Andreas Pitzschke, Ying Xiao

Although the versatility of photodynamic therapy (PDT) is well established, the technical aspects of light delivery systems vary significantly depending on the targeted organ. This article describes the optical properties of a light and drug delivery syste ...

2020

In vivo autofluorescence imaging of early cancers in the human tracheobronchial tree with a spectrally optimized system

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

The changes in the autofluorescence characteristics of the bronchial tissue is of crucial interest as a cancer diagnostic tool. Evidence exists that this native fluorescence or autofluorescence of bronchial tissues changes when they turn dysplastic and to ...

SPIE Society of Photo-optical Instrumentation Engineers2003

Optical properties of rabbit brain in the red and near-infrared: changes observed under in vivo, postmortem, frozen, and formalin-fixated conditions

Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Blaise Lovisa, Andreas Pitzschke

The outcome of light-based therapeutic approaches depends on light propagation in biological tissues, which is governed by their optical properties. The objective of this study was to quantify optical properties of brain tissue in vivo and postmortem and a ...

SPIE Society of Photo-optical Instrumentation Engineers2015

Absolute autofluorescence spectra of human healthy, metaplastic, and early cancerous bronchial tissue in vivo

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

Autofluorescence is emerging as a useful tool for the detection of early cancers in the bronchi. It has already produced interesting results, which have been implemented in commercial imaging devices. Their design relies on the spectroscopy of the tissues ...

2001

Noninvasive determination of the optical properties of two-layered turbid media

Hubert van den Bergh, Georges Wagnières

Light propagation in two-layered turbid media having an infinitely thick second layer is investigated in the steady-state, frequency, and time domains. A solution of the diffusion approximation to the transport equation is derived by employing the extrapol ...

1998

Stimulation and homogenization of the protoporphyrin IX endogenous production by photobiomodulation to increase the potency of photodynamic therapy

Georges Wagnières, Jaroslava Joniová, Emmanuel Louis Arthur Gerelli, Cyrus Kazemiraad

Protoporphyrin IX (PpIX) is produced in the mitochondria and used as fluorescent contrast agent or photosensitizer after exogenous 5-aminolevulinic acid (ALA) delivery in cancer photodynamic detection and therapy (PDT). Although routinely used in the clini ...

ELSEVIER SCIENCE SA2021

Probing the Interaction Between a Surfactant-Cobalt(III) Complex and Bovine Serum Albumin

Hubert van den Bergh, Georges Wagnières

The mechanism of binding of the surfactant-cobalt(III) complex, cis-[Co(phen) 2(C 14H 29NH 2)Cl](ClO 4) 2{dot operator}3H 2O (phen = 1,10-phenanthroline, C 14H 29NH 2 = tetradecylamine) with bovine serum albumin (BSA) was investigated by UV-vis absorption, ...

Springer US2012

Treatment of pleural malignancies by photo-induction combined to systemic chemotherapy: Proof of concept on rodent lung tumors and feasibility study on porcine chest cavities

Georges Wagnières, Michaël Bensimon, Elodie Debefve

Background: Low-dose, Visudyne (R)-mediated photodynamic therapy (photo-induction) was shown to selectively enhance tumor vessel transport causing increased uptake of systemically administered chemotherapy in various tumor types grown on rodent lungs. The ...

Wiley-Blackwell2015

Antibody-indocyanin conjugates for immunophotodetection of human squamous cell carcinoma in nude mice

Hubert van den Bergh, Georges Wagnières

The authors have recently shown that immunophotodetection of human colon carcinomas in nude mice and in patients is possible by using anti-carcinoembryonic antigen monoclonal antibodies (MAb) coupled to fluorescein. The most common clin. application of pho ...

1994

Photodynamic therapy for the treatment of atherosclerotic plaque: Lost in translation?

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

Acute coronary syndrome is a life-threatening condition of utmost clinical importance, which, despite recent progress in the field, is still associated with high morbidity and mortality. Acute coronary syndrome results from a rupture or erosion of vulnerab ...

Wiley2017

In-vivo fluence rate effect in photodynamic therapy of early cancers with tetra(m-hydroxyphenyl)chlorin

Hubert van den Bergh, Georges Wagnières

Several parameters affect clin. trials in photodynamic therapy and influence the therapeutic outcome. Beside drug dose, light dose, drug-light interval and other variables, the fluence rate is a parameter that can influence the therapeutic results. In this ...

1996

EPR and spectrophotometric studies of free radicals (O2.-, .OH, BPD-MA.-) and singlet oxygen (1O2) generated by irradiation of benzoporphyrin derivative monoacid ring A

Hubert van den Bergh, Georges Wagnières

Benzoporphyrin deriv. monoacid ring A [BPD-MA (I)], a chlorin-type mol., is a new photosensitizer currently in phase II clin. trials for the treatment by photodynamic therapy of cancerous lesions, psoriasis and pathol. neovascularization. The photochem. (t ...

1997

Study and optimization of the photobiomodulation effects induced on mitochondrial metabolic activity of human cardiomyocytes for different radiometric and spectral conditions

Georges Wagnières, Jaroslava Joniová, Emmanuel Louis Arthur Gerelli

Photobiomodulation (PBM) represents a promising and powerful approach for non-invasive therapeutic interventions. This emerging field of research has gained a considerable attention due to its potential for multiple disciplines, including medicine, neurosc ...

2024

Fluence plays a critical role on the subsequent distribution of chemotherapy and tumor growth delay in murine mesothelioma xenografts pre-treated by photodynamic therapy

Georges Wagnières

Background: The pre-conditioning of tumor vessels by low-dose photodynamic therapy (L-PDT) was shown to enhance the distribution of chemotherapy in different tumor types. However, how light dose affects drug distribution and tumor response is unknown. Here ...

Wiley-Blackwell2015