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Thomas Rizzo

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Publications associées (100)

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Analyzing glycans cleaved from a biotherapeutic protein using ultrahigh-resolution ion mobility spectrometry together with cryogenic ion spectroscopy

Thomas Rizzo, Priyanka Bansal, Ali H Abikhodr, Vasyl Yatsyna, Natalia Yalovenko

Glycans covalently attached to protein biotherapeutics have a significant impact on their biological activity, clearance, and safety. As a result, glycosylation is categorized as a critical quality attribute that needs an adequate analytical approach to gu ...

2020

Conformational Structures of a Decapeptide Validated by First Principles Calculations and Cold Ion Spectroscopy

Thomas Rizzo, Oleg Boyarkine, Vladimir Kopysov, Natalia Nagornova

Calculated structures of the two most stable conformers of a protonated decapeptide gramicidin S in the gas phase have been validated by comparing the vibrational spectra, calculat- ed from first- principles and measured in a wide spectral range using infr ...

Wiley-V C H Verlag Gmbh2015

Conformational dependence of intramolecular vibrational redistribution in methanol

Thomas Rizzo, Oleg Boyarkine, Pavlo Maksyutenko

Previous state-selected spectra of methanol in the 5ν1 OH stretch overtone region [O. V. Boyarkin, T. R. Rizzo, and D. S. Perry, J. Chem. Phys. 110 (23), 11346 (1999)] revealed structure indicating intramolecular vibrational redistribution (IVR) on three t ...

2007

Glycosaminoglycan Analysis by Cryogenic Messenger-Tagging IR Spectroscopy Combined with IMS-MS

Thomas Rizzo, Michael Zachary Kamrath, Chiara Masellis

We combine ion mobility spectrometry with cryogenic, messenger-tagging, infrared spectroscopy and mass spectrometry to . identify different isomeric disaccharides of chondroitin sulfate (CS) and heparan sulfate (HS), which are representatives of two major ...

2017

Conformation-specific infrared and ultraviolet spectroscopy of tyrosine-based protonated dipeptides

Thomas Rizzo, Oleg Boyarkine

We present the spectroscopy and photofragmentation dynamics of two isomeric protonated dipeptides, H+AlaTyr and H+TyrAla, in a cold ion trap. By a combination of infrared-ultraviolet double resonance experiments and density functional theory calculations, ...

2007

Cryogenic IR spectroscopy combined with ion mobility spectrometry for the analysis of human milk oligosaccharides

Thomas Rizzo, Michael Zachary Kamrath, Chiara Masellis

We report here our combination of cryogenic, messenger-tagging, infrared (IR) spectroscopy with ion mobility spectrometry (IMS) and mass spectrometry (MS) as a way to identify and analyze a set of human milk oligosaccharides (HMOs) ranging from trisacchari ...

2018

Cryogenic Spectroscopy and Quantum Molecular Dynamics Determine the Structure of Cyclic Intermediates Involved in Peptide Sequence Scrambling

Ursula Röthlisberger, Thomas Rizzo, Oleg Aseev

Collision-induced dissociation (CID) is a key technique used in mass spectrometry-based peptide sequencing. Collisionally activated peptides undergo statistical dissociation, forming a series of backbone fragment ions that reflect their amino acid (AA) seq ...

2015

Feshbach resonances in the water molecule revealed by state-selective spectroscopy

Thomas Rizzo, Oleg Boyarkine, Pavlo Maksyutenko, Maxim Grechko

We employ triple-resonance vibrational overtone excitation to access quasibound states of water from several fully characterized bound states of the molecule. Comparison of the measured dissociation spectra allows a rigorous assignment of rotational quantu ...

American Institute of Physics2010

Going large(r): general discussion

Thomas Rizzo

ROYAL SOC CHEMISTRY2019

HE-LHC: The High-Energy Large Hadron Collider Future Circular Collider Conceptual Design Report Volume 4

Yi Zhang, Jan Steggemann, Hua Zhang, Elena Graverini, Jeffrey Alan Hubbell, Pierluigi Bruzzone, Jean-Michel Sallese, Mingkui Wang, Luca Rossi, Mikhail Chapochnikov, Thomas Rizzo, Mathias Oleg Knecht, Doohyun Kim, Yu Bai, Fabio Avino, Xavier Buffat, Andrea Wulzer, Tatiana Pieloni, Michael Schenk, Florian Patrick Marie Daniel De la Barre De Nanteuil, Marco Drewes, Mithlesh Kumar, Alexandra Sarabando de Carvalho, Alban Sublet, Lorena Gonçalves de Alcântara e Freitas Krikler, Alexej Grudiev, Roberto Contino, José Luis Abelleira Fernández, Francesco Cerutti, Sondre Vik Furuseth, Giovanni Migliorati, Vincenzo D'Auria, Luca Vecchi, Javier Barranco Garcia, Claudia Tambasco, Sandra Aumon, Georgi Gorine, Bernhard Auchmann, Lotta Maria Mether, Léon Van Riesen-Haupt, Marc-Olivier Sauvain, Leonid Rivkin, Agnieszka Chmielinska, Eva Maria Rodriguez Franco

In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider ...

2019

A New Approach for Identifying Positional Isomers of Glycans Cleaved from Monoclonal Antibodies

Thomas Rizzo, Ahmed Ben Faleh, Stephan Warnke, Priyanka Bansal, Vasyl Yatsyna, Natalia Yalovenko

SWISS CHEMICAL SOC2022

Collisionally-assisted spectroscopy of water from 27000 to 34000 cm-1

Thomas Rizzo, Oleg Boyarkine, Pavlo Maksyutenko, Maxim Grechko

We report here an experimental approach that enables measurement of weak transitions to a wide range of rovibrational levels of water in the energy region 27000-34200 cm-1. We have previously demonstrated the use of laser double-resonance overtone excitati ...

2008

Cold Ion Spectroscopy Reveals the Intrinsic Structure of a Decapeptide

Ursula Röthlisberger, Ivano Tavernelli, Thomas Rizzo, Oleg Boyarkine, Natalia Nagornova, Manuel Dömer, Matteo Guglielmi

Wiley-VCH Verlag GmbH2011

Communication: Feshbach resonances in the water molecule revealed by state-selective spectroscopy (vol 133, 081103, 2010)

Thomas Rizzo, Oleg Boyarkine, Pavlo Maksyutenko, Maxim Grechko

2010

Toward High-Throughput Cryogenic IR Fingerprinting of Mobility-Separated Glycan Isomers

Thomas Rizzo, Ahmed Ben Faleh, Stephan Warnke

Infrared (IR) spectroscopy is a powerful tool used to infer detailed structural information on molecules, often in conjunction with quantum-chemical calculations. When applied to cryogenically cooled ions, IR spectra provide unique fingerprints that can be ...

2021

Spectroscopic signatures of gas-phase helices: Ac-Phe-(Ala)5-Lys-H+ and Ac-Phe-(Ala)10-Lys-H+

Thomas Rizzo, Oleg Boyarkine

We apply gas-phase double resonance spectroscopic techniques to two helical peptides, Ac-Phe-(Ala)5-Lys-H+ and Ac-Phe- (Ala)10-Lys-H+, using electrospray ionization combined with photofragmentation in a cold, 22-pole ion trap. Despite the large size of the ...

2007

Vibrational overtone spectroscopy of jet-cooled methanol from 5000 to 14000 cm(-1)

Thomas Rizzo, Oleg Boyarkine

Spectra of jet-cooled methanol in the overtone and combination region from 5000 to, 14000 cm(-1) have been obtained by means of infrared laser-assisted photofragment spectroscopy. Many of the observed features are assigned to combination bands of the type ...

2005

Efficient, highly selective laser isotope separation of carbon-13

Thomas Rizzo, Oleg Boyarkine

We recently demonstrated an original approach to highly selective laser isotope separation of carbon-13 that employs vibrational overtone pre-excitation of CF3 H together with infrared multiphoton dissociation [O.V. Boyarkin, M. Kowalczyk, T.R. Rizzo, J. C ...

Springer-Verlag2006

A Planar Multipole Ion Trap/Time-of-Flight Mass Spectrometer

Thomas Rizzo, Ulrich Lorenz

We present a novel, hybrid ion trap/time-of-flight mass spectrometer that is based on a planar multipole design. Compared with Paul trap/time-of-flight instruments, this design possesses the principal advantages of higher injection efficiency and more homo ...

2011

Infrared Spectroscopy of Mobility-Selected H+-Gly-Pro-Gly-Gly (GPGG)

Ursula Röthlisberger, Thomas Rizzo, Michael Zachary Kamrath, Antoine Louis Claude Masson

We report the first results from a new instrument capable of acquiring infrared spectra of mobility-selected ions. This demonstration involves using ion mobility to first separate the protonated peptide Gly-Pro-Gly-Gly (GPGG) into two conformational famili ...

2015