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Giorgio Margaritondo

Cette personne a quitté l’EPFL

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Publications associées (132)

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X-ray microscopy and tomography detect the accumulation of bare and PEG-coated gold nanoparticles in normal and tumor mouse tissues

Giorgio Margaritondo

We demonstrate that, with appropriate staining, high-resolution X-ray microscopy can image complicated tissue structures-cerebellum and liver-and resolve large or small amounts of Au nanoparticles in these tissues. Specifically, images of tumor tissue reve ...

Springer Heidelberg2012

Three-dimensional (3D) polypyrrole microstructures with high aspect ratios fabricated by localized electropolymerization

Giorgio Margaritondo

We present the three-dimensional (3D) growth of polypyrrole (PPy) microstructures with high aspect ratios (HAR) by a localized electropolymerization. The radicals formed by an oxidation of Py monomer is localized on the targeting area due to a confinement ...

American Chemical Society2008

Synchrotron light in semiconductor research: Three decades of revolution

Giorgio Margaritondo

Since the late 1960s, synchrotron-based experimental techniques have been playing a key role in semiconductor research. Major milestones include the observation of intrinsic and extrinsic surface and interface states, the study of interface formation proce ...

2006

Virtual X-ray Reading (VXR) of Ancient Administrative Handwritten Documents

Giorgio Margaritondo, Frédéric Kaplan, Fauzia Albertin

The study of ancient documents is too often confined to specimens of high artistic value or to official writings. Yet, a wealth of information is often stored in administrative records such as ship records, notary papers, work contract, tax declaration, co ...

2014

Teaching about the birth of synchrotron light: the role of Frascati and a missed opportunity

Giorgio Margaritondo

The users of synchrotron light are now tens of thousands throughout the world. Paradoxically, many of them do not know much about the early history of their domain. This is regrettable, since education about the initial developments makes it easier to full ...

2024

Synchrotron refractive-index microradiography of human liver cancer tissue

Yiming Li, Giorgio Margaritondo

Three human liver tissue samples (similar to 5 mm x 40 mm x 20 mm) were excised from a cancer patient's liver during surgery. The microradiology analysis was performed with a non-standard approach on a synchrotron. High-resolution refractive-index edge-enh ...

2005

Q&A: Why use synchrotron x-ray tomography for multi-scale connectome mapping?

Giorgio Margaritondo

To understand how information flows and is used in the human brain, we must map neural structures at all levels, providing visualizations similar to those of Google Earth for continents, countries, cities, and streets. Unfortunately, the imaging and proces ...

2017

Hard-x-ray microscopy with Fresnel zone plates reaches 40 nm Rayleigh resolution

Chao Wang, Giorgio Margaritondo

Substantial improvements in the nanofabrication and characteristics of gold Fresnel zone plates yielded unprecedented resolution levels in hard-x-ray microscopy. Tests performed on a variety of specimens with 8-10 keV photons demonstrated a first-order lat ...

American Institute of Physics2008

Optimization of Gold Nanoparticle Photoluminescence by Alkanethiolation

Giorgio Margaritondo

Surface thiolation was recently found to affect two important properties of gold nanoparticles: their size and the presence of visible luminescence under UV stimulation. We explored these phenomena by systematically analysing alkanethiolate coatings with d ...

Royal Society of Chemistry2015

Full-field microimaging with 8 keV X-rays achieves a spatial resolutions better than 20 nm

Giorgio Margaritondo

Fresnel zone plates (450 nm thick Au, 25 nm outermost zone width) used as objective lenses in a full field transmission reached a spatial resolution better than 20 nm and 1.5% efficiency with 8 keV photons. Zernike phase contrast was also realized without ...

Optical Society of America2011

Very small photoluminescent gold nanoparticles for multimodality biomedical imaging

Giorgio Margaritondo

An original synthesis method based on X-ray irradiation produced gold nanoparticles (AuNPs) with two important properties for biomedical research: intense visible photoluminescence and very high accumulation in cancer cells. The nanoparticles, coated with ...

Elsevier2013

Gold nanoparticles as multimodality imaging agents for brain gliomas

Giorgio Margaritondo

Background: Nanoparticles can be used for targeted drug delivery, in particular for brain cancer therapy. However, this requires a detailed analysis of nanoparticles from the associated microvasculature to the tumor, not easy because of the required high s ...

Biomed Central Ltd2015

Three-Dimensional Writing of Highly Stretchable Organic Nanowires

Giorgio Margaritondo

Three-dimensional (3D) writing is a promising approach to realize stretchable electronics, but is so far limited to microscale features. We developed accurate 3D writing for highly stretchable organic nanowire arrays using a nanoscale polymer meniscus. Spe ...

2012

Quantitative analysis of nanoparticle internalization in mammalian cells by high resolution X-ray microscopy

Giorgio Margaritondo

Background: Quantitative analysis of nanoparticle uptake at the cellular level is critical to nanomedicine procedures. In particular, it is required for a realistic evaluation of their effects. Unfortunately, quantitative measurements of nanoparticle uptak ...

BioMed Central2011

One-Pot Tuning of Au Nucleation and Growth: From Nanoclusters to Nanoparticles

Giorgio Margaritondo

We describe a simple and effective method to obtain colloidal surface-functionalized Au nanoparticles. The method is primarily based on irradiation of a gold solution with high-flux X-rays from a synchrotron source in the presence of 11-mercaptoundecanoic ...

American Chemical Society2011

The relativistic foundations of synchrotron radiation

Giorgio Margaritondo

Special relativity (SR) determines the properties of synchrotron radiation, but the corresponding mechanisms are frequently misunderstood. Time dilation is often invoked among the causes, whereas its role would violate the principles of SR. Here it is show ...

International Union of Crystallography (IUCr)2017

Virtual reading of a large ancient handwritten science book

Giorgio Margaritondo, Frédéric Kaplan, Alessandra Patera, Fauzia Albertin

We present a fundamental development step of a new technique to read and digitize ancient handwritten documents. Chemical analysis by x-ray fluorescence and x-ray tomography enabled us to decipher words and drawings from inside a closed, 200-pages 18 th ce ...

Elsevier2016

3D experimental investigation of the microstructure of cement pastes using synchrotron X-ray microtomography (mu CT)

Giorgio Margaritondo, Karen Scrivener, Amela Groso

Cement pastes aged from 1 to 60 days were studied using synchrotron microtomography on the MS-X04SA beam line at the Swiss Light Source. This allowed three dimensional images to be obtained with a resolution approaching that of backscattered electron image ...

Pergamon-Elsevier Science Ltd2007

Synchrotron microradiography study on acute lung injury of mouse caused by PM2.5 aerosols

Yiming Li, Giorgio Margaritondo

In order to investigate FeSO4, ZnSO4 (the two of main metal compositions of Shanghai PM2.5 (particle matter with those aerodynamical diameter

Elsevier2006

Real-time radiology in the microscale

Giorgio Margaritondo

We present several examples of the applications of a novel microradiology approach based on unmonochromatized synchrotron x-rays. The approach - mostly implemented on the ICPCIR (International Consortium on Phase Contrast Imaging and Radiology) Beamline at ...

2005