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Giorgio Margaritondo

Cette personne a quitté l’EPFL

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Publications associées (132)

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Enhanced photocatalysis, colloidal stability and cytotoxicity of synchrotron X-ray synthesized Au/TiO2 nanoparticles

Giorgio Margaritondo

Au/TiO2 nanocomposite particles were synthesized by a method based on intense X-ray irradiation without adding any reducing agent or stabilizer. The nanocomposite exhibits promising photocatalytic and biological properties at physiologically relevant conce ...

Elsevier2009

Enhancement of irradiation effects on cancer cells by cross-linked dextran-coated iron oxide (CLIO) nanoparticles

Giorgio Margaritondo

We investigated iron oxide nanoparticles with two different surface modifications, dextran coating and cross-linked dextran coating, showing that their different internalization affects their capability to enhance radiation damage to cancer cells. The inte ...

Institute of Physics2010

Gold nanoparticles as high-resolution X-ray imaging contrast agents for the analysis of tumor-related micro-vasculature

Giorgio Margaritondo

Background: Angiogenesis is widely investigated in conjunction with cancer development, in particular because of the possibility of early stage detection and of new therapeutic strategies. However, such studies are negatively affected by the limitations of ...

BioMed Central2012

Intense X-ray induced formation of silver nanoparticles stabilized by biocompatible polymers

Giorgio Margaritondo

Colloidal Ag nanoparticles were formed by X-ray irradiation in the presence of a polymer. This new synthesis method is simple, rapid and leads to a high production yield. Compared to the citrate-reduced Ag colloidal, polymer-protected Ag nanoparticles are ...

2009

Nondestructive Characterization by Advanced Synchrotron Light Techniques: Spectromicroscopy and Coherent Radiology

Giorgio Margaritondo

The advanced characteristics of synchrotron light has led in recent years to the development of a series of new experimental techniques to investigate chemical and physical properties on a microscopic scale. Although originally developed for materials scie ...

2008

Infrared Scanning Near-Field Optical Microscopy Below the Diffraction Limit

Giorgio Margaritondo

Infrared scanning near-field optical microscopy (IR-SNOM) is an extremely powerful analytical instrument since it combines IR spectroscopy's high chemical specificity with SNOM's high spatial resolution. In order to do this in the infrared, specialty chalc ...

2008

SYNAPSE: An international roadmap to large brain imaging

Giorgio Margaritondo

Since 2020, synchrotron radiation facilities in several Asia-Pacific countries have been collaborating in a major project called "SYNAPSE"(Synchrotrons for Neuroscience: an Asia-Pacific Scientific Enterprise). They use x-ray imaging to attack in a coordina ...

ELSEVIER2022

Controlled hydrogel photopolymerization inside live systems by X-ray irradiation

Giorgio Margaritondo

We successfully demonstrate the in situ formation by X-ray irradiation induced polymerization of a three-dimensional (3D) hydrogel based on poly(ethylene glycol) (PEG) diacrylate (PEG DA), with the option of heparin incorporation to enhance cell adhesion. ...

Royal Society of Chemistry2012

Imaging the cellular uptake of tiopronin-modified gold nanoparticles

Giorgio Margaritondo

Well-dispersed gold nanoparticles (NP) coated with tiopronin were synthesized by X-ray irradiation without reducing agents. High-resolution transmission electron microscopy shows that the average core diameters of the NPs can be systematically controlled b ...

Springer Verlag2011

Tailored Au nanorods: optimizing functionality, controlling the aspect ratio and increasing biocompatibility

Giorgio Margaritondo

Monodisperse gold nanorods with high aspect ratio were synthesized by x-ray irradiation. Irradiation was first used to stimulate the creation of seeds. Afterward, nanorod growth was stimulated either by chemical reduction or again by x-ray irradiation. In ...

Institute of Physics2010

Comparison of unmonochromatized synchrotron radiation and conventional X-rays in the imaging of mammographic phantom and human breast specimens: A preliminary result

Giorgio Margaritondo

A simple imaging setup based on the principle of coherence-based contrast X-ray imaging with unmonochromatized synchrotron radiation was used for studying mammographic phantom and human breast specimens. The use of unmonochromatized synchrotron radiation s ...

2005

One-pot synthesis of AuPt alloyed nanoparticles by intense x-ray irradiation

Giorgio Margaritondo

We synthesized AuPt alloyed nanoparticles in colloidal solution by a one-pot procedure based on synchrotron x-ray irradiation in the presence of PEG (polyethylene glycol). The exclusive presence of alloyed nanoparticles with fcc structure was confirmed by ...

Institute of Physics2011

The serpin Spn5 is essential for wing expansion in Drosophila melanogaster

Giorgio Margaritondo, Vincent Gajdosik

Serpins, a superfamily of protease inhibitors, control proteolytic cascades in many physiological processes. Genomic studies have revealed the presence of a high number of serpin-encoding genes in Drosophila melanogaster, but their functions remain largely ...

University of the Basque Country Press2008

X-ray synthesized PEGylated (polyethylene glycol coated) gold nanoparticles in mice strongly accumulate in tumors

Giorgio Margaritondo

The spatial distribution of X-ray synthesized, PEG coated Au nanoparticles in cancer-bearing mice and their time dependent accumulation were investigated with inductive coupled plasma - optical emission spectroscopy (ICP-OES), transmission electron microsc ...

Elsevier2011

Hydrogen bubbles and the growth morphology of ramified zinc by electrodeposition

Giorgio Margaritondo

Real-time X-ray microscopy was used to study the influence of hydrogen-bubble formation on the morphology of ramified zinc electrodeposit. The experimental results show that when intense hydrogen bubbling occurs at high potential, the morphology of the ram ...

2008

Coupled tomography and distinct-element-method approach to exploring the granular media microstructure in a jamming hourglass

Giorgio Margaritondo, Michaël Unser, Thomas Liebling, Daniel Sage, Lionel Pournin, Slobodan Mitrovic, Marco Ramaioli, Michel Tsukahara, Slobodan Mitrovic, Vincent Gajdosik

We describe an approach for exploring microscopic properties of granular media that couples x-ray microtomography and distinct-element-method (DEM) simulations through image analysis. We illustrate it via the study of the intriguing phenomenon of instant a ...

APS2008

Morphological study of early-stage lung cancer using synchrotron radiation

Giorgio Margaritondo

In the present study the feasibility of applying synchrotron radiation to the morphological study of early-stage lung cancer has been investigated. Lewis lung cancer was implanted and grown in a nude mouse for different periods, and imaged using phase-cont ...

International Union of Crystallography2008

Firefly Light Flashing: Oxygen Supply Mechanism

Giorgio Margaritondo

Firefly luminescence is an intriguing phenomenon with potential technological applications, whose biochemistry background was only recently established. The physics side of this phenomenon, however, was still unclear, specifically as far as the oxygen supp ...

2014

Spectroscopic infrared scanning near-field optical microscopy (IR-SNOM)

Giorgio Margaritondo, Dusan Vobornik

Scanning near-field optical microscopy (SNOM or NSOM) is the technique with the highest lateral optical resolution available today, while infrared (IR) spectroscopy has a high chemical specificity. Combining SNOM with a tunable IR source produces a unique ...

Elsevier2005

Altered branching patterns of Purkinje cells in mouse model for cortical development disorder

Giorgio Margaritondo

Disrupted cortical cytoarchitecture in cerebellum is a typical pathology in reeler. Particularly interesting are structural problems at the cellular level: dendritic morphology has important functional implication in signal processing. Here we describe a c ...

Nature Publishing Group2011