Publications de Andrzej Kulik | EPFL Graph Search

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Correlations between adhesion hysteresis and local friction are theoretically and experimentally investigated. The model is based on the classical theory of adhesional friction, contact mechanics, capillary hysteresis, and nanoscale roughness. Adhesion hys ...

Thermal position fluctuations of a colloidal particle in an optical trap are measured with microsecond resolution using back-focal-plane interferometry. The mean-square displacement MSD(t) and power spectral density are in excellent agreement with the theo ...

We have previously shown that the switch from N-cadherin to OB-cadherin expression increases intercellular adhesion between fibroblasts during their transition from a migratory to a fibrogenic phenotype. Using atomic force microscopy we here show that part ...

We performed dynamic force spectroscopy of single dextran and titin 127 molecules using small-amplitude and low-frequency (40-240 Hz) dithering of an atomic force microscope tip excited by a sine wave voltage fed onto the tip-carrying piezo. We show that f ...

A novel method for quantitative lateral force measurement (LFM) calibration has been developed. Using a single-molecule spectroscopy approach it is possible to calibrate the AFM levers for both lateral and normal spring constants with a single image scan. ...

Dystrophin mediates a physical link between the cytoskeleton of muscle fibers and the extracellular matrix, and its absence leads to muscle degeneration and dystrophy. In this article, we show that the lack of dystrophin affects the elasticity of individua ...

Central to the biological function of microtubules. is their ability to modify their length which occurs by addition and removal of subunits at the ends of the polymer, both in vivo and in vitro. This dynamic behavior is strongly influenced by temperature. ...

The influence of the surface morphology of semicrystalline polyamide 12 PA12! on the adhesion of thin silicon oxide coatings is analyzed by means of uniaxial fragmentation tests and scanning local-acceleration microscopy SLAM!. Two types of PA12 substrates are investigated, namely, as-received PA12, which contains large spherulites, and quenched PA12, which has a relatively smooth, homogeneous surface structure. The adhesion of the coating is found to be identical for the two types of PA12. This indicates t

The thermal position fluctuations of a single micron-sized sphere immersed in a fluid were recorded by optical trapping interferometry with nanometer spatial and microsecond temporal resolution. We find, in accord with the theory of Brownian motion includi ...

We have developed a new hybrid AFM probe combining an SU-8 polymer body with a full tungsten cantilever having a nanometric tip. The fabrication is based on surface micromachining a silicon wafer, where tungsten is sputter deposited in oxidation sharpened ...

Contactin-4 (CNTN4) is a complex cell adhesion molecule (CAM) localized at neuronal membranes, playing a key role in maintaining the mechanical integrity and signaling properties of the synapse. CNTN4 consists of six immunoglobulin C2 type (IgC2) domains a ...

We use a single molecule atomic force spectroscopy combined with the steered molecular dynamics simulation to determine a mechanical behavior of neural cell adhesion protein contactin during its unfolding. Force curves typical for modular proteins were obs ...

The expression of N-cadherin, characteristic of various cancers, very often leads to changes in the cells' adhesive properties. Thus, we sought to find out if N-cadherin expressed in various, but cancer-related cells, differs in its functional properties t ...

We report a comprehensive in vitro study of the photo-oxidative stress on different biomolecular and cellular targets generated in the presence of fullerol C-60(OH)(n), a novel, fullerene-based and water-soluble sensitizer of singlet oxygen ((1)Delta(g)). ...

An innovative way to fix preformed nanocrystalline TiO2 on low-density polyethylene film (LDPE-TiO2) is presented. The LDPE-TiO2 film was able to mediate the complete photodiscoloration of Orange II using about seven times less catalyst than a TiO2 suspens ...

An analysis of the tribo-mechanical properties of the Ni-Co system, at the submicrometric contact scale, is conducted using displacement sensing nanoindentation. In particular, the influence of contact depth and surface finishing methods on the hardness, H ...

Andrzej Kulik

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Correlations between adhesion hysteresis and friction at molecular scales

Motion of a colloidal particle in an optical trap

Fibrogenic fibroblasts increase intercellular adhesion strength by reinforcing individual OB-cadherin bonds

Can Dissipative Properties of Single Molecules Be Extracted from a Force Spectroscopy Experiment?

A single-molecule stretching method for lateral and normal AFM lever calibration

Gene-mediated Restoration of Normal Myofiber Elasticity in Dystrophic Muscles

Temperature-Dependent Elasticity of Microtubules

Effect of substrate crystalline morphology on the adhesion of plasma enhanced chemical vapor deposited thin silicon oxide coatings on polyamide

Direct observation of nondiffusive motion of a Brownian particle

Electrically conducting probes with full tungsten cantilever and tip for scanning probe applications

Nanomechanics of multidomain neuronal cell adhesion protein contactin revealed by single molecule AFM and SMD

Erratum to “Preparation, stabilization and characterization of TiO2 on thin polyethylene films (LDPE). Photocatalytic applications"

AFM Force Spectroscopy and Steered Molecular Dynamics Simulation of Protein Contactin 4

Specific detection of glycans on a plasma membrane of living cells with atomic force microscopy

Characterization of N-cadherin unbinding properties in non-malignant (HCV29) and malignant (T24) bladder cells

Singlet oxygen ((1)Delta(g))-mediated oxidation of cellular and subcellular components: ESR and AFM assays

Preparation, stabilization and characterization of TiO2 on thin polyethylene films (LDPE): Photocatalytic applications

A displacement sensing nanoindentation study of tribo-mechanical properties of the Ni-Co system

Effect of ultraviolet light irradiation on macroscopic single-walled carbon nanotube bundles

MechStiff: A New Tool for Evaluating Stress-Induced Dynamics and Application to Cell Adhesion Proteins