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Rudolf Hovius

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Publications associées (34)

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Chromatin Fiber Invasion and Nucleosome Displacement by the Rap1 Transcription Factor

Rudolf Hovius, Beat Fierz, Iuliia Boichenko, Maxime Nicolas Mivelaz, Anne-Marinette Thi Phuong Hanh Cao

Pioneer transcription factors (pTFs) bind to target sites within compact chromatin, initiating chromatin remodeling and controlling the recruitment of downstream factors. The mechanisms by which pTFs overcome the chromatin barrier are not well understood. ...

2020

Evaluating Cellular Drug Uptake with Fluorescent Sensor Proteins

Kai Johnsson, Rudolf Hovius, Rudolf Griss, Kui Thong Tan, Silvia Scarabelli

We are introducing a new approach to evaluate cellular uptake of drugs and drug candidates into living cells. The approach is based on converting the protein target of a given class of compounds into a fluorescent biosensor. By measuring the binding of dif ...

Amer Chemical Soc2017

A covalently linked probe to monitor local membrane properties surrounding plasma membrane proteins

Luc Reymond, Rudolf Hovius

We present a method probing the local membrane environment surrounding membrane proteins in the plasma membrane by linking a solvatochromic dye to the target, and provide evidence for lipid-based sorting. The insulin receptor environment changed upon insul ...

Rockefeller University Press2022

Downscaling the Analysis of Complex Transmembrane Signaling Cascades to Closed Attoliter Volumes

Horst Arthur Vogel, Rudolf Hovius, Romain Wyss, Joachim Piguet, Luigino Grasso, Ghérici Hassaïne, Michael Werner

Cellular signaling is classically investigated by measuring optical or electrical properties of single or populations of living cells. Here we show that ligand binding to cell surface receptors and subsequent activation of signaling cascades can be monitor ...

Public Library of Science2013

Correlated Optical and Electrical Single-Molecule Measurements Reveal Conformational Diffusion from Ligand Binding to Channel Gating in the Nicotinic Acetylcholine Receptor

Horst Arthur Vogel, Rudolf Hovius, Davor Kosanic

Wiley-Blackwell2011

A fluorogenic probe for SNAP-tagged plasma membrane proteins based on the solvatochromic molecule Nile Red

Kai Johnsson, Luc Reymond, Rudolf Hovius, Efthymia Prifti

A fluorogenic probe for plasma membrane proteins based on the dye Nile Red and SNAP-tag is introduced. It takes advantage of Nile Red, a solvatochromic molecule highly fluorescent in an apolar environment, such as cellular membranes, but almost dark in a p ...

Amer Chemical Soc2014

Covalent labeling of cell-surface proteins for in-vivo FRET studies

Horst Arthur Vogel, Kai Johnsson, Rudolf Hovius, Jean-Manuel Segura, Nathalie George, Bruno Meyer

Fluorescence resonance energy transfer (FRET) is a powerful technique to reveal interactions between membrane proteins in live cells. Fluorescence labeling for FRET is typically performed by fusion with fluorescent proteins (FP) with the drawbacks of a lim ...

2006

The HP1 box of KAP1 organizes HP1α for silencing of endogenous retroviral elements in embryonic stem cells

Matteo Dal Peraro, Beat Fierz, Rudolf Hovius, Maria Josefina Marcaida Lopez

Repression of endogenous retroviral elements (ERVs) is facilitated by KAP1 (KRAB-associated protein 1)-containing complexes, however the underlying mechanism remains unclear. Here, we show that binding of KAP1 to the major component of the heterochromatin ...

Springer Science and Business Media LLC2025

Fluorescent Epibatidine Agonists for Neuronal and Muscle-Type Nicotinic Acetylcholine Receptors

Horst Arthur Vogel, Rudolf Hovius, Jörg Grandl

Wiley-VCH Verlag GmbH2007

Microfluidic Single-Cell Analysis with Affinity Beads

Horst Arthur Vogel, Rudolf Hovius, Michael Werner, Loïc Arvind Roger Arm

A micrometer-sized affinity bead (red) is (i) taken up into a cell by phagocytosis, (ii) photochemically released from phagosomes, (iii) optically trapped by the cell, and (iv) isolated by cell lysis for subsequent analysis of captured intracellular analyt ...

2015

Microfluidic single cell analysis with affinity beads

Horst Arthur Vogel, Rudolf Hovius, Michael Werner, Loïc Arvind Roger Arm

Springer2013

A Chemogenetic Approach for the Optical Monitoring of Voltage in Neurons

Kai Johnsson, Luc Reymond, Rudolf Hovius, Efthymia Prifti

Wiley-VCH Verlag GmbH2018

Biomimetic Sequestration of CO2: reprogramming the B1 domain of protein g through a combined computational and experimental approach

Ursula Röthlisberger, Rudolf Hovius, Esra Bozkurt

Wiley-Blackwell2015

Lipid-coated nanocrystals as multifunctionalized luminescent scaffolds for supramolecular biological assemblies

Horst Arthur Vogel, Ravindranathan Thampi, Rudolf Hovius, Isabelle Geissbühler Bärlocher

Nanometer light source: Interaction between high-affinity binding sites on lipid-coated nanocrystals (NCs) and different proteins enables the controlled formation of supramol. nanostructures on micropatterned surfaces. The NCs serve as local light sources ...

Wiley-VCH Verlag GmbH2005