Arnaud Comment

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Publications associées (110)

Proton NMR of15N-choline metabolites enhanced by dynamic nuclear polarization

Arnaud Comment, Geoffrey Bodenhausen, Rolf Gruetter, Sami Jannin, Riddhiman Sarkar, Paul Romeo Vasos

(Figure Presented) Chemical shifts of protons can report on metabolic transformations such as the conversion of choline to phosphocholine. To follow such processes in vivo, magnetization can be enhanced by dynamic nuclear polarization (DNP). We have hyperp ...

2009

Hyperpolarized Lithium-6 as a Sensor of Nanomolar Contrast Agents

Arnaud Comment, Jacques Van Der Klink, Chiara Perazzolo, Rolf Gruetter, Sami Jannin, Ruud van Heeswijk, Fiodar Kurdzesau, Cristina Ramona Cudalbu

Lithium is widely used in psychotherapy. The Li-6 isotope has a long intrinsic longitudinal relaxation time T-1 on the order of minutes, making it an ideal candidate for hyperpolarization experiments. In the present study we demonstrated that lithium-6 can ...

Wiley-Blackwell2009

Dynamic nuclear polarization of small labelled molecules in frozen water-alcohol solutions

Arnaud Comment, Jacques Van Der Klink, Sami Jannin, Fiodar Kurdzesau

In recent years methods of creating 'hyperpolarized' substances have gained considerable attention in biomedical magnetic resonance and dynamic nuclear polarization (DNP) is one of the most promising, especially for imaging applications. Here we present re ...

2008

In Vivo Detection of Hyperpolarized 15N Choline in the Rat

Arnaud Comment, Chiara Perazzolo, Rolf Gruetter, Sami Jannin, Ruud van Heeswijk, Fiodar Kurdzesau, Cristina Ramona Cudalbu

2008

Principles of operation of a DNP prepolarizer coupled to a rodent MRI scanner

Arnaud Comment, Jacques Van Der Klink, Rolf Gruetter, Sami Jannin, Fiodar Kurdzesau

A dynamic nuclear polarization prepolarizer was developed and coupled to a 9.4 T rodent magnetic resonance imaging scanner in order to perform in vivo hyperpolarization experiments. In the present paper, emphasis is put on methods and hardware performance ...

2008

A 140 GHz prepolarizer for dissolution dynamic nuclear polarization

Arnaud Comment, Jacques Van Der Klink, Sami Jannin, Fiodar Kurdzesau

Apart from their very classical use to build polarized targets for particle physics, the methods of dynamic nuclear polarization (DNP) have more recently found application for sensitivity enhancement in high-resolution NMR, both in the solid and in the liq ...

2008

Producing over 100 ml of highly concentrated hyperpolarized solution by means of dissolution DNP

Arnaud Comment, Jacques Van Der Klink, Sami Jannin, Ruud van Heeswijk, Fiodar Kurdzesau

New low-temperature inserts compatible with an existing hyperpolarizer were developed to dynamically polarize nuclei in large samples. The performance of the system was tested on 8 ml glassy frozen solutions containing 13C-labeled molecules and doped with ...

Academic Press Inc - Elsevier Science2008

Design and performance of a DNP prepolarizer coupled to a rodent MRI scanner

Arnaud Comment, Jacques Van Der Klink, Rolf Gruetter, Sami Jannin, Fiodar Kurdzesau

For most of the last forty years, the techniques of Dynamic Nuclear Polarization (DNP) have been confined to particle-physics laboratories building polarized targets, but recently it has been shown that samples similar to a solid target can be transformed ...

2007

Add-on extends the capability of a conventional NMR spectrometer

Arnaud Comment, Jean-Philippe Ansermet

A spectrometer allowing the measurement of signals with spin-spin relaxation times as short as 0.5 μs has been developed. It consists of a transmitter based on a commercial spectrometer and a homemade receiver. The acquired signals are imported in the soft ...

Academic Press Inc - Elsevier Science2005

Magnetic properties of pure and Gd-doped EuO probed by NMR

Arnaud Comment, Jean-Philippe Ansermet

An Eu NMR study in the ferromagnetic phase of pure and Gd-doped EuO was performed. A complete description of the NMR line shape of pure EuO allowed for the influence of doping EuO with Gd impurities to be highlighted. The presence of a temperature-dependen ...

2005

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