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Arnaud Comment

Cette personne a quitté l’EPFL

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Publications associées (110)

Page 3 sur 6

Ultra-High Field Birdcage Coils: a Comparison Study at 14.1T

Rolf Gruetter, Arnaud Comment, Hongxia Lei, Tian Cheng

An essential feature of magnetic resonance (MR) probes for magnetic resonance imaging and spectroscopy is the ability to generate uniform B-1(+) excitation in a volume of interest. When the magnetic field strength is increased, leading to an increase in re ...

Ieee2014

Automated transfer and injection of hyperpolarized molecules with polarization measurement prior to in vivo NMR

Arnaud Comment, Josefina Adriana Maria Bastiaansen, Tian Cheng, Mor-Miri Mishkovsky

Hyperpolarized magnetic resonance via dissolution dynamic nuclear polarization necessitates the transfer of the hyperpolarized molecules from the polarizer to the imager prior to in vivo measurements. This process leads to unavoidable losses in nuclear pol ...

2013

Hyperpolarized 13C lactate as a substrate for in vivo metabolic studies in skeletal muscle

Rolf Gruetter, Arnaud Comment, Josefina Adriana Maria Bastiaansen, Hikari Ananda Infinity Yoshihara, Yuhei Takado

Resting skeletal muscle has a preference for the oxidation of lipids compared to carbohydrates and a shift towards carbohydrate oxidation is observed with increasing exercise. Lactate is not only an end product in skeletal muscle but also an important meta ...

2014

Imaging liver and brain glycogen metabolism at the nanometer scale

Anders Meibom, Arnaud Comment, Graham Knott, Stéphane Laurent Escrig, Yuhei Takado

In mammals, glycogen synthesis and degradation are dynamic processes regulating blood and cerebral glucose-levels within a well-defined physiological range. Despite the essential role of glycogen in hepatic and cerebral metabolism, its spatiotemporal distr ...

Elsevier Science Bv2015

Add-on extends the capability of a conventional NMR spectrometer

Jean-Philippe Ansermet, Arnaud Comment

A spectrometer allowing the measurement of signals with spin-spin relaxation times as short as 0.5 μs has been developed. It consists of a transmitter based on a commercial spectrometer and a homemade receiver. The acquired signals are imported in the soft ...

Academic Press Inc - Elsevier Science2005

Hyperpolarized 6Li as a probe for hemoglobin oxygenation level

Rolf Gruetter, Arnaud Comment, Mor-Miri Mishkovsky, Ruud van Heeswijk, Riccardo Balzan

Hyperpolarization by dissolution dynamic nuclear polarization (DNP) is a versatile technique to dramatically enhance the nuclear magnetic resonance (NMR) signal intensity of insensitive long-T1 nuclear spins such as 6 Li. The 6 Li longitudinal relaxation o ...

Wiley-Blackwell2016

Hyperpolarizing Gases via Dynamic Nuclear Polarization and Sublimation

Rolf Gruetter, Geoffrey Bodenhausen, Jean-Philippe Ansermet, Arnaud Comment, François Lazeyras, Sami Jannin, Pascal Miéville, Riddhiman Sarkar, Paul Romeo Vasos, Jean-Noël Hyacinthe, Puneet Ahuja

A high throughput method was designed to produce hyperpolarized gases by combining lowtemperature dynamic nuclear polarization with a sublimation procedure. It is illustrated by applications to 129Xe nuclear magnetic resonance in xenon gas, leading to a si ...

American Physical Society2010

Proton NMR of15N-choline metabolites enhanced by dynamic nuclear polarization

Rolf Gruetter, Geoffrey Bodenhausen, Arnaud Comment, Sami Jannin, Riddhiman Sarkar, Paul Romeo Vasos

(Figure Presented) Chemical shifts of protons can report on metabolic transformations such as the conversion of choline to phosphocholine. To follow such processes in vivo, magnetization can be enhanced by dynamic nuclear polarization (DNP). We have hyperp ...

2009

Principles of operation of a DNP prepolarizer coupled to a rodent MRI scanner

Rolf Gruetter, Arnaud Comment, Sami Jannin, Jacques Van Der Klink

A dynamic nuclear polarization prepolarizer was developed and coupled to a 9.4 T rodent magnetic resonance imaging scanner in order to perform in vivo hyperpolarization experiments. In the present paper, emphasis is put on methods and hardware performance ...

2008

Measuring changes in substrate utilization in the myocardium in response to fasting using hyperpolarized [1-(13)C]butyrate and [1-(13)C]pyruvate

Arnaud Comment, Josefina Adriana Maria Bastiaansen

Cardiac dysfunction is often associated with a shift in substrate preference for ATP production. Hyperpolarized (HP) (13)C magnetic resonance spectroscopy (MRS) has the unique ability to detect real-time metabolic changes in vivo due to its high sensitivit ...

Nature Research2016

The metabolic effect of hyperpolarized [1-13C]acetate dosage in vivo

Rolf Gruetter, Arnaud Comment, Josefina Adriana Maria Bastiaansen, Tian Cheng, Mor-Miri Mishkovsky

2011

A 140 GHz prepolarizer for dissolution dynamic nuclear polarization

Arnaud Comment, Sami Jannin, Jacques Van Der Klink

Apart from their very classical use to build polarized targets for particle physics, the methods of dynamic nuclear polarization (DNP) have more recently found application for sensitivity enhancement in high-resolution NMR, both in the solid and in the liq ...

2008

In vivo real time cardiac metabolism using hyperpolarized acetate

Rolf Gruetter, Arnaud Comment, Josefina Adriana Maria Bastiaansen, Tian Cheng

2012

Over 35% liquid-state 13C polarization via dissolution dynamic nuclear polarization at 7 T and 1 K with ubiquitous nitroxyl radicals

Arnaud Comment, Tian Cheng, Andrea Capozzi, Riccardo Balzan, Yuhei Takado

The most versatile method to increase liquid-state 13C NMR sensitivity is dissolution dynamic nuclear polarization. The use of trityl radicals is usually required to obtain very large 13C polarization via this technique. We herein demonstrate that up to 35 ...

Royal Soc Chemistry2013

Kinetic analysis of acetylCoA synthetase activity in skeletal muscle

Rolf Gruetter, Arnaud Comment, João Miguel das Neves Duarte, Josefina Adriana Maria Bastiaansen, Tian Cheng, Mor-Miri Mishkovsky

2012

Method for the generation of radicals for dynamic nuclear polarization and uses thereof for nmr, mrs and mri

Arnaud Comment, Christophe Roussel, Tim Rolf Eichhorn

A method for the preparation of a sample comprising highly polarized nuclear spins is proposed, comprising at least the following steps: a) provision of molecules with 1,2-dione structural units and/or molecules with 2,5-diene-1,4-dione structural units in ...

2016

13C DNP efficiency in function of the glassing matrix content at different magnetic fields

Arnaud Comment, Tian Cheng, Andrea Capozzi, Riccardo Balzan

2013

Photoinduced Nonpersistent Radicals as Polarizing Agents for X-Nuclei Dissolution Dynamic Nuclear Polarization

Arnaud Comment, Giovanni Boero, Tian Cheng, Christophe Roussel, Andrea Capozzi, Jean-Noël Hyacinthe, Jacques Van Der Klink, Tim Rolf Eichhorn

Hyperpolarization via dissolution dynamic nuclear polarization (DNP) is a versatile method to dramatically enhance the liquid-state NMR signal of X-nuclei and can be used for performing metabolic and molecular imaging. It was recently demonstrated that ins ...

American Chemical Society2015

In vivo enzymatic assay of carnitine acetyl transferase and acetylCoA synthetase using hyperpolarized acetate

Rolf Gruetter, Arnaud Comment, Josefina Adriana Maria Bastiaansen, Tian Cheng, Mor-Miri Mishkovsky

2012

Sample preparation for CryoNanoSIMS

Tian Cheng, Anders Meibom, Arnaud Comment, Stéphane Laurent Escrig, Louise Helene Soegaard Jensen, Florent Olivier Vivien Plane

2019