Mitotic catastropheMitotic catastrophe has been defined as either a cellular mechanism to prevent potentially cancerous cells from proliferating or as a mode of cellular death that occurs following improper cell cycle progression or entrance. Mitotic catastrophe can be induced by prolonged activation of the spindle assembly checkpoint, errors in mitosis, or DNA damage and functioned to prevent genomic instability. It is a mechanism that is being researched as a potential therapeutic target in cancers, and numerous approved therapeutics induce mitotic catastrophe.
G0 phaseDISPLAYTITLE:G0 phase The G0 phase describes a cellular state outside of the replicative cell cycle. Classically, cells were thought to enter G0 primarily due to environmental factors, like nutrient deprivation, that limited the resources necessary for proliferation. Thus it was thought of as a resting phase. G0 is now known to take different forms and occur for multiple reasons. For example, most adult neuronal cells, among the most metabolically active cells in the body, are fully differentiated and reside in a terminal G0 phase.
Théorie de la démonstrationLa théorie de la démonstration, aussi connue sous le nom de théorie de la preuve (de l'anglais proof theory), est une branche de la logique mathématique. Elle a été fondée par David Hilbert au début du . Hilbert a proposé cette nouvelle discipline mathématique lors de son célèbre exposé au congrès international des mathématiciens en 1900 avec pour objectif de démontrer la cohérence des mathématiques.
Assistant de preuveEn informatique (ou en mathématiques assistées par informatique), un assistant de preuve est un logiciel permettant la vérification de preuves mathématiques, soit sur des théorèmes au sens usuel des mathématiques, soit sur des assertions relatives à l'exécution de programmes informatiques. Beaucoup de projets ont été lancés pour formaliser les mathématiques, en 1966, Nicolaas de Bruijn lance le projet Automath, suivi par d'autres projets.
Fuseau mitotiquevignette|480x480px|Fuseau mitotique à la métaphase, on retrouve les 2 centrosomes, les divers types de microtubules et les différents moteurs protéiques.Le fuseau mitotique, ou appareil mitotique achromatique, est un système mis en place par les cellules eucaryotes pour permettre la migration des chromatides lors de la division cellulaire dès le stade de la prophase. Il est constitué de microtubules et de protéines associées et forme un véritable fuseau entre les pôles opposés d’une cellule.
Cyclin-dependent kinase 1Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation. It has been highly studied in the budding yeast S. cerevisiae, and the fission yeast S. pombe, where it is encoded by genes cdc28 and cdc2, respectively. With its cyclin partners, Cdk1 forms complexes that phosphorylate a variety of target substrates (over 75 have been identified in budding yeast); phosphorylation of these proteins leads to cell cycle progression.
Cell growthCell growth refers to an increase in the total mass of a cell, including both cytoplasmic, nuclear and organelle volume. Cell growth occurs when the overall rate of cellular biosynthesis (production of biomolecules or anabolism) is greater than the overall rate of cellular degradation (the destruction of biomolecules via the proteasome, lysosome or autophagy, or catabolism). Cell growth is not to be confused with cell division or the cell cycle, which are distinct processes that can occur alongside cell growth during the process of cell proliferation, where a cell, known as the mother cell, grows and divides to produce two daughter cells.
Queuing delayIn telecommunication and computer engineering, the queuing delay or queueing delay is the time a job waits in a queue until it can be executed. It is a key component of network delay. In a switched network, queuing delay is the time between the completion of signaling by the call originator and the arrival of a ringing signal at the call receiver. Queuing delay may be caused by delays at the originating switch, intermediate switches, or the call receiver servicing switch.
Mating of yeastThe yeast Saccharomyces cerevisiae is a simple single-celled eukaryote with both a diploid and haploid mode of existence. The mating of yeast only occurs between haploids, which can be either the a or α (alpha) mating type and thus display simple sexual differentiation. Mating type is determined by a single locus, MAT, which in turn governs the sexual behaviour of both haploid and diploid cells. Through a form of genetic recombination, haploid yeast can switch mating type as often as every cell cycle. S.
End-to-end delayEnd-to-end delay or one-way delay (OWD) refers to the time taken for a packet to be transmitted across a network from source to destination. It is a common term in IP network monitoring, and differs from round-trip time (RTT) in that only path in the one direction from source to destination is measured. The ping utility measures the RTT, that is, the time to go and come back to a host. Half the RTT is often used as an approximation of OWD but this assumes that the forward and back paths are the same in terms of congestion, number of hops, or quality of service (QoS).
Transmission delayIn a network based on packet switching, transmission delay (or store-and-forward delay, also known as packetization delay or serialization delay) is the amount of time required to push all the packet's bits into the wire. In other words, this is the delay caused by the data-rate of the link. Transmission delay is a function of the packet's length and has nothing to do with the distance between the two nodes.
Délai de commutationLe délai de commutation est le temps nécessaire à un commutateur pour recevoir complètement un paquet et le retransmettre sur un système à commutation de paquets en mode différé (ou mode Store and Forward). Le délai de commutation est généralement mesuré en multiples ou en fractions de seconde. Le délai peut différer légèrement, selon l'emplacement de la paire spécifique de points de terminaison de communication.
