LipophilieLa lipophilie caractérise l'affinité chimique d'une matière ou d'une molécule pour les graisses. C'est en chimie généralement équivalent à l'hydrophobie. En effet, les corps gras sont des solvants apolaires, alors que l'eau est un solvant polaire. Les molécules solubles dans les solvants polaires ne le sont généralement pas ou peu dans les solvants apolaires, et inversement. Certaines molécules, dites amphiphiles, présentent une partie polaire (donc hydrophile/lipophobe) et une partie apolaire (donc hydrophobe/lipophile).
Thin-film drug deliveryThin-film drug delivery uses a dissolving film or oral drug strip to administer drugs via absorption in the mouth (buccally or sublingually) and/or via the small intestines (enterically). A film is prepared using hydrophilic polymers that rapidly dissolves on the tongue or buccal cavity, delivering the drug to the systemic circulation via dissolution when contact with liquid is made. Thin-film drug delivery has emerged as an advanced alternative to the traditional tablets, capsules and liquids often associated with prescription and OTC medications.
Métabolisme des médicamentsDrug metabolism is the metabolic breakdown of drugs by living organisms, usually through specialized enzymatic systems. More generally, xenobiotic metabolism (from the Greek xenos "stranger" and biotic "related to living beings") is the set of metabolic pathways that modify the chemical structure of xenobiotics, which are compounds foreign to an organism's normal biochemistry, such as any drug or poison. These pathways are a form of biotransformation present in all major groups of organisms and are considered to be of ancient origin.
