Mediaspace scheduled maintenance: Aug 25, 2026 07:00 - 12:00 AM. During this time, videos will be temporarily unavailable. Check status updates.

Séance de cours

Bases pharmacologiques

Dans cours

BIO-480: Neuroscience: from molecular mechanisms to disease

The goal of the course is to guide students through the essential aspects of molecular neuroscience and neurodegenerative diseases. The student will gain the ability to dissect the molecular basis of disease in the nervous system in order to begin to under ...

Description

Cette séance de cours couvre la synthèse de l'épinéphrine, le mécanisme d'action de la Ritaline en tant qu'amplificateur cognitif et les effets de différents médicaments sur les neurotransmetteurs. Les exercices comprennent l'identification des médicaments pour la maladie d'Alzheimer, la compréhension de la puissance par rapport à l'efficacité et la discussion sur l'utilisation des anesthésiques. La séance de cours explore également les différences entre les toxines comme le botox et les bengotoxines, leurs effets sur les synapses et le rôle des neurotransmetteurs dans la régulation de la fonction cardiaque.

Enseignant·e·s (4)

Bernard Schneider

Johannes Gräff

Academic appointments 2013- Tenure Track Assistant Professor, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland, School of Life Sciences, Brain Mind Institute. 2009-2013 Postdoctoral fellow, Massachusetts Institute of Technology (MIT), Cambridge, USA, Picower Institute for Learning and Memory. 2009 Postdoctoral associate, Swiss Federal Institute of Technology (ETHZ), Zürich, Switzerland, Brain Research Institute. Education 2009 PhD in Neurosciences, Swiss Federal Institute of Technology (ETHZ), Zürich, Switzerland, Department of Biology, Brain Research Institute. 2005 Diploma (M.Sc. equivalent) in Biological Sciences, University of Lausanne, Switzerland, Faculty of Biology and Medicine, Department of Ecology and Evolution. 1998 Matura, Gymnasium Type B, Kantonsschule am Burggraben St. Gallen, Switzerland.

Hilal Lashuel

2012-2013 Visiting Professor, Standford University. Stanford School of Medicine 2011- Associate Professor of Life Sciences-Brain Mind Institute-EPFL Dir. Laboratory of Chemical Biology of Neurodegeneration 2005-2011 Assistant Professor of Life Sciences-Brain Mind Institute-EPFL Dir. Laboratory of Molecular Neurobiology and Neuroproteomics 2005-2008 Director- EPFL Proteomic Core Facility 2002-2004 Instructor of Neurology- Harvard Medical School and Brigham and Women's Hospital 2001-2002 Sabbatical Fellow- Laboratory for Drug Discovery in Neurodegeneration Harvard Medical School, 2001-2002 Post-doctoral Fellow- Center for Neurologic Diseases Harvard Medical School and Brigham and Women's Hospital Advisor- Prof. Peter T. Lansbury 2000-2001 Research Scientist, The Picower Institute for Medical Research, Great Neck New York 1994-2000 PhD Student; Texas A&M University and the Scripps Research Institute Advisor- Prof. Jeffery W. Kelly 1990-1994 B.S. City University of New York, Brooklyn College Dr. Hilal A. Lashuel received his B.Sc. degree in chemistry from the City University of New York in 1994 and completed his doctoral studies at Texas A&M University and the Scripps Research Institute in 2000. After obtaining his doctoral degree, he became a research fellow at the Picower Institute for Medical Research in Long Island New York. In 2001, he moved to Harvard Medical School and the Brigham and Women's Hospital as a research fellow in the Center for Neurologic Diseases and was later promoted to an instructor in neurology at Harvard Medical School. During his tenure (2001-2004) at Harvard Medical School his work focused on understanding the mechanisms of protein misfolding and fibrillogenesis and the role of these processes in the pathogenesis of Parkinson's and Alzheimer's disease. In 2005 Dr. Lashuel moved Switzerland to join the Brain Mind Institute at the Swiss Federal Institute of Technology Lausanne as a tenure-track assistant professor in neurosciences. Currently, Dr. Lashuel is an associate professor of life sciences and the director of the laboratory of molecular and chemical biology of neurodegeneration. (http://lashuel-lab.epfl.ch/). Research efforts in the Lashuels laboratory focus on understanding the molecular mechanisms of neurodegeneration and developing novel strategies to diagnose and treat neurodegenerative diseases such as Alzheimers and Parkinsons disease. Research in the Lashuel lab is funded by several international funding agencies and foundations, including the Swiss National Science Foundation, European FP7 program (Marie Curie and ERC grants), Human Science Frontiers, Strauss Foundation, Cure the Huntingtons disease foundation and Michael J Fox foundation and is supported by collaborations with pharmaceutical and biotech companies (http://lashuel-lab.epfl.ch/page-50538-en.html), Nestle, Merck-Serono, AC Immune and Johnson and Johnson. Dr. Lashuels research has resulted in the characterization of novel quaternary structure intermediates on the amyloid pathway, identification of potential therapeutic targets, and new hypotheses concerning the mechanisms of pathogenesis in Alzheimers disease, Parkinsons disease and related disorders. Dr. Lashuel scientific contribution to this field includes i) more than100 publications in major peer reviewed journals including Nature journals, Cell, PNAS, JBC, J. Neuroscience JACS, and Angewandtie Chemie; ii) three patents on novel strategies for preventing protein aggregation and treating autoimmune and inflammatory diseases; iii) more than 150 invited lectures since 2002 and more than 5500 citations (7800 citation-Google Scholar) since 1996. Dr. Lashuel has received several pre-doctoral and post-doctoral awards and fellowships and was the recipient of two prestigious awards given to young investigators; Human Science Frontiers young investigator research award and the European Research Council (ERC) starting independent researcher grant and the ERC proof of concept award (2013) These awards provide more than $2.5 Million to Dr. Lashuel to translate some of his ideas and projects into novel strategies for diagnosing and treating neurodegenerative diseases such as Alzheimers and Parkinsons disease. Dr. Lashuel has chaired and co-organized several international conferences and serves as an academic editor for PLoS ONE, an associate editor for frontiers of molecular neuroscience, member of the Editorial advisory board of ChemBioChem and ad hoc reviewer for several international scientific journals and funding agencies.

Source officielle

Concepts associés (22)

Neurotransmetteur

Les neurotransmetteurs, ou neuromédiateurs, sont des composés chimiques libérés par les neurones (et parfois par les cellules gliales) agissant sur d'autres neurones, appelés neurones postsynaptiques, ou, plus rarement, sur d'autres types de cellules (comme les cellules musculaires et les cellules gliales comme les astrocytes). Les neurotransmetteurs sont stockés au niveau de l'élément présynaptique dans des vésicules. Le contenu de ces vésicules est libéré (de à molécules en moyenne) dans l'espace synaptique au moment de l'arrivée d'un potentiel d'action.

Monoamine

Les monoamines sont des neurotransmetteurs dérivés d'acides aminés, comportant un groupement éthylamine (amine NH2 lié par un pont C2H5) lié à un noyau aromatique. On distingue notamment les catécholamines et les tryptamines (dont la sérotonine) respectivement dérivés de la tyrosine et du tryptophane. Leur localisation est principalement dans le système nerveux central, où ils jouent un rôle de neuromodulation. Les monoamines sont particulièrement impliqués dans la régulation des états de vigilance et de l'humeur.

Retrograde signaling

Retrograde signaling in biology is the process where a signal travels backwards from a target source to its original source. For example, the nucleus of a cell is the original source for creating signaling proteins. During retrograde signaling, instead of signals leaving the nucleus, they are sent to the nucleus. In cell biology, this type of signaling typically occurs between the mitochondria or chloroplast and the nucleus. Signaling molecules from the mitochondria or chloroplast act on the nucleus to affect nuclear gene expression.

Cœur

Le cœur est un organe musculaire creux qui assure la circulation sanguine en pompant le sang vers les vaisseaux sanguins et les cavités du corps à travers des contractions rythmiques. L'adjectif cardiaque veut dire « qui a un rapport avec le cœur » ; il vient du grec kardia (καρδία) « cœur » , et de la racine indo-européenne ḱḗr (« entrailles »). Fichier:Heart left ventricular outflow track.jpg|Coupe frontale du ventricule gauche du cœur humain. Fichier:Le Cœur Humaine avec des Annotations.

Insuffisance cardiaque chez l'humain

L’insuffisance cardiaque (IC) ou défaillance cardiaque correspond à un état dans lequel une anomalie de la fonction cardiaque est responsable de l'incapacité du myocarde à assurer un débit cardiaque suffisant pour couvrir les besoins énergétiques de l'organisme. Cette défaillance peut être le reflet d'une anomalie de la contraction du muscle cardiaque ventriculaire (dysfonction systolique) ou de remplissage (dysfonction diastolique), voire des deux mécanismes.

Afficher plus

Séances de cours associées (32)

Neurotransmetteurs : récepteurs et effets

Explore les principaux neurotransmetteurs, leurs effets, la pharmacothérapie et les mécanismes récepteurs dans le fonctionnement du cerveau.

Neurotransmetteurs Aperçu

Fournit un aperçu des neurotransmetteurs, de leur rôle dans le sommeil, la toxicomanie et le LTP, et l'étude des comportements addictifs.

Physiologie par systèmes : Corrections des séances d'exercice

Couvre les corrections pour les séances d'exercice liées à la physiologie par système.

Système cardiovasculaire: Introduction

Couvre le but et l'anatomie du système cardiovasculaire, y compris le cœur, les vaisseaux sanguins et les vaisseaux lymphatiques.

Transmission synaptique: Structure et Mécanismes MOOC: Simulation de la neuroscience

Explore la structure et la fonction des synapses, y compris la diversité des neurotransmetteurs et le rôle des récepteurs AMPA et NMDA.

Afficher plus

Concepts associés (22)

Insuffisance cardiaque chez l'humain

Afficher plus