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Concept

Entrainment (chronobiology)

Publications associées (25)

Mice with humanized livers reveal the role of hepatocyte clocks in rhythmic behavior

Benjamin Dieter Weger, Cédric Gobet, Frédéric Bruno Martin Gachon

The synchronization of circadian clock depends on a central pacemaker located in the suprachiasmatic nuclei. However, the potential feedback of peripheral signals on the central clock remains poorly characterized. To explore whether peripheral organ circad ...

AMER ASSOC ADVANCEMENT SCIENCE2023

The circadian clock time tunes axonal regeneration

Thomas Haynes Hutson

Nerve injuries cause permanent neurological disability due to limited axonal regeneration. Injury-dependent and-independent mechanisms have provided important insight into neuronal regeneration, however, common denominators underpinning regeneration remain ...

Cell Press2023

Integrating non-visual effects of light in the automated daylight-responsive control of blinds and electric lighting

Marta Benedetti

The use of daylight in buildings is important because it contributes to energy savings by reducing the use of electric lighting and space heating. It also impacts on biological functions and on well-being. Indeed, light not only allows vision, but has non- ...

EPFL2021

Space-time logic of liver gene expression at sub-lobular scale

Felix Naef, Colas Noé Droin, Clémence Yumie Syloun Hurni

The mammalian liver is a central hub for systemic metabolic homeostasis. Liver tissue is spatially structured, with hepatocytes operating in repeating lobules, and sub-lobule zones performing distinct functions. The liver is also subject to extensive tempo ...

NATURE RESEARCH2021

Multi-omics reveals abundant mitochondrial genomic and circadian expression variation in the Drosophila Genetic Reference Panel

Maria Litovchenko

Modern biology rapidly generates a wealth of data,which can only be analysed computationally.Despite the variety of available data types,most of them aim to provide an answer to one question: how does genotypic diversity translates into phenotypes? This qu ...

EPFL2020

Chronotype: Implications for Epidemiologic Studies on Chrono-Nutrition and Cardiometabolic Health

Frédéric Bruno Martin Gachon

Chrono-nutrition is an emerging research field in nutritional epidemiology that encompasses 3 dimensions of eating behavior: timing, frequency, and regularity. To date, few studies have investigated how an individual's circadian typology, i.e., one's chron ...

OXFORD UNIV PRESS2019

Tissue-specific circadian transcriptional regulation

Jake Yeung

Circadian rhythms in physiology and behavior evolved to resonate with daily cycles in the external environment. In mammals, organs orchestrate temporal physiology over the 24-hour day, which requires extensive gene expression rhythms targeted to the right ...

EPFL2019

Sleep-wake-driven and circadian contributions to daily rhythms in gene expression and chromatin accessibility in the murine cortex

Felix Naef, Jake Yeung, Maxime Jan

The timing and duration of sleep results from the interaction between a homeostatic sleep-wake-driven process and a periodic circadian process, and involves changes in gene regulation and expression. Unraveling the contributions of both processes and their ...

National Academy of Sciences2019

Rhythms of the Genome: Circadian Dynamics from Chromatin Topology, Tissue-Specific Gene Expression, to Behavior

Felix Naef, Jake Yeung

Circadian rhythms in physiology and behavior evolved to resonate with daily cycles in the external environment. In mammals, organs orchestrate temporal physiology over the 24-h day, which requires extensive gene expression rhythms targeted to the right tis ...

ELSEVIER SCIENCE LONDON2018

Pancreatic α- and β-Cellular Clocks Have Distinct Molecular Properties and Impact on Islet Hormone Secretion and Gene Expression

Michaël Unser, Daniel Sage, Frédéric Bruno Martin Gachon, Cédric Gobet

A critical role of circadian oscillators in orchestrating insulin secretion and islet gene transcription has been demonstrated recently. However, these studies focused on whole islets and did not explore the interplay between α-cell and β-cell clocks. We p ...

2017

A new promoter element associated with daily time keeping in Drosophila

Felix Naef, Eric Paquet

Circadian clocks are autonomous daily timekeeping mechanisms that allow organisms to adapt to environmental rhythms as well as temporally organize biological functions. Clock-controlled timekeeping involves extensive regulation of rhythmic gene expression. ...

Oxford University Press2017

Regulation of Mammalian Physiology by interconnected Circadian and Feeding Rhythms

Cédric Gobet, Frédéric Bruno Martin Gachon, Benjamin Dieter Weger, Daniel Alain Dominique Marie Mauvoisin

Circadian clocks are endogenous timekeeping systems that adapt in an anticipatory fashion the physiology and behavior of most living organisms. In mammals, the master pacemaker resides in the suprachiasmatic nucleus and entrains peripheral clocks using a w ...

Frontiers Media Sa2017

Glucose Homeostasis: Regulation by Peripheral Circadian Clocks in Rodents and Humans

Frédéric Bruno Martin Gachon

Most organisms, including humans, have developed an intrinsic system of circadian oscillators, allowing the anticipation of events related to the rotation of Earth around its own axis. The mammalian circadian timing system orchestrates nearly all aspects o ...

Endocrine Soc2017

Evidence for Rhythmicity Pacemaker in the Calcification Process of Scleractinian Coral

Anders Meibom, Jaroslaw Hubert Stolarski, Isabelle Domart-Coulon

Reef-building scleractinian (stony) corals are among the most efficient bio-mineralizing organisms in nature. The calcification rate of scleractinian corals oscillates under ambient light conditions, with a cyclic, diurnal pattern. A fundamental question i ...

Nature Research2016

Diurnal variations of hormonal secretion, alertness and cognition in extreme chronotypes under different lighting conditions

Jean-Louis Scartezzini, Mirjam Münch, Apiparn Borisuit, Lenka Maierova

Circadian rhythms in physiology and behavior are modulated by external factors such as light or temperature. We studied whether self-selected office lighting during the habitual waking period had a different impact on alertness, cognitive performance and h ...

Nature Publishing Group2016

Circadian clock-dependent and -independent rhythmic proteomes implement distinct diurnal functions in mouse liver

Felix Naef, Frédéric Bruno Martin Gachon, Daniel Alain Dominique Marie Mauvoisin, Jingkui Wang

Diurnal oscillations of gene expression controlled by the circadian clock underlie rhythmic physiology across most living organisms. Although such rhythms have been extensively studied at the level of transcription and mRNA accumulation, little is known ab ...

National Academy of Sciences2014

Circadian rhythms in insect disease vectors

Antonio Carlos Alves Meireles Filho

Organisms from bacteria to humans have evolved under predictable daily environmental cycles owing to the Earth's rotation. This strong selection pressure has generated endogenous circadian clocks that regulate many aspects of behaviour, physiology and meta ...

Fundaco Oswaldo Cruz2013

Modelling 'non-visual' effects of daylighting in a residential environment

Marilyne Andersen, Sharon Jane Gochenour

The importance of light not only as a therapeutic tool but as an essential element of healthy living has been highlighted by the recent discovery of a specialized photoreceptor in the eye responsible for synchronizing our internal circadian pacemaker. This ...

Elsevier2013

Light and chronobiology: Implications for health and disease

Mirjam Münch

Environmental light synchronizes the primary mammalian biological clock in the suprachiasmatic nuclei, as well as many peripheral clocks in tissues and cells, to the solar 24-hour day. Light is the strongest synchronizing agent (zeitgeber) for the circadia ...

Les Laboratories Servier2012

Effects of prior light exposure on early evening performance, subjective sleepiness, and hormonal secretion

Jean-Louis Scartezzini, Friedrich Linhart, Mirjam Münch, Apiparn Borisuit

In sighted humans, light intensity, timing, exposure duration, and spectral composition of light are important to entrain the endogenous circadian pacemaker to the 24-h day-night cycle. We tested the impact of two realistic office lighting conditions durin ...

American Psychological Association2012