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Publications associées (32)

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Synthetic methodologies for C-C and C-N bond formation involving alkyl radicals

Guido Barzanò

C-C and C-N bonds are some of the most common structures in molecules ranging from drugs to catalysts and to food additives. Many coupling reactions were developed to form these types of bonds with excellent selectivity and good performance. Still, the syn ...

EPFL2020

Functional and Responsive Polymers via Controlled Radical Polymerization

Jian Wang

This Thesis is built around 4 topics, which share in common that they all take advantage of the assets of controlled radical polymerization to either (i) prepare well-defined model systems to address fundamental research questions with regard to the sensit ...

EPFL2020

Towards the Sarpagine-Ajmaline-Macroline Family of Indole Alkaloids: Enantioselective Synthesis of an N-Demethyl Alstolactone Diastereomer

Jieping Zhu, Qian Wang, Dylan Jean Robert Dagoneau

the strategy involving the use of functionalized tetrahydro-6H-cycloocta[b]indol-6-one is reported as a key intermediate for synthesis of members of the sarpagine-ajmaline-macroline family of monoterpene indole alkaloids. The desired tricycle was synthesiz ...

WILEY-V C H VERLAG GMBH2020

Tailoring Chiral Cyclopentadienyl Rhodium(III) Catalysts for Enantioselective Alkenyl C-H functionalizations

Coralie Danielle Annick Duchemin

Chiral cyclopentadienyl (Cpx) metal complexes have empowered the developement of challenging asymmetric C(sp2)-H activation transformations. However the preparation of competent atropchiral Cpx ligands is long and tedious. Moreover the range of application ...

EPFL2020

Mechanistic Studies of Two Ni-Catalyzed Reactions: Reductive Amidation of Esters with Nitroarenes and Hydrosilylation of Alkenes

Marten Leendert Ploeger

Mechanistic investigations into homogeneously catalyzed reactions are essential for the fur-ther development of synthetic methodologies. Insights in the overall reaction pathway and vital steps such as the rate-determining and selectivity-determining steps ...

EPFL2020

Enantioselective (CpRhIII)-Rh-x-Catalyzed Carboaminations of Acrylates

Nicolai Cramer, Coralie Danielle Annick Duchemin

Enantioselective carboaminations of olefins constitute an attractive strategy for a rapid increase in molecular complexity from readily available starting materials. Reported here is an intermolecular asymmetric carboamination of acrylates using rhodium(II ...

Wiley-VCH Verlag GmbH2020

Electrophile Signaling and Emerging Immuno- and Neuro-modulatory Electrophilic Pharmaceuticals

Yimon Aye, Jesse Poganik

With a lipid-rich environment and elevated oxygen consumption, the central nervous system (CNS) is subject to intricate regulation by lipid-derived electrophiles (LDEs). Investigations into oxidative damage and chronic LDE generation in neural disorders ha ...

FRONTIERS MEDIA SA2020

Versatile Route to trans-Platinum(II) Complexes via Manipulation of a Coordinated 3-(Pyridin-3-yl)propanoicAcid Ligand

Paul Joseph Dyson, Tina Riedel

We describe the direct coupling of alcohols and amines to a 3-(pyridin-3-yl)propanoic acid ligand coordinated to a Pt(II) to afford ester and amide derivatives. Using this approach, a family of trans-Pt(II) compounds with amine ligands bearing long perfluo ...

2019

Copper-Catalyzed 1,2-Methoxy Methoxycarbonylation of Alkenes with Methyl Formate

Qian Wang, Jieping Zhu, Alexandre Julien Florent Leclair, Balázs Budai

Reported here is a copper-catalyzed 1,2-methoxy methoxycarbonylation of alkenes by an unprecedented use of methyl formate as a source of both the methoxy and the methoxycarbonyl groups. This reaction transforms styrene and its derivatives into value-added ...

Wiley-VCH Verlag GmbH2019

A 1,3,2-Diazaphospholene-Catalyzed Reductive Claisen Rearrangement

Nicolai Cramer, Pavel Alexandrovich Donets, John Henry Reed, Solène Florie Miaskiewicz

1,3,2-Diazaphospholenes (DAPs) are an emerging class of organic hydrides. In this work, we exploited them as efficient catalysts for very mild reductive Claisen rearrangements. The method is tolerant towards a wide variety of functional groups and operates ...

Wiley-VCH Verlag GmbH2019

Analysis of functional groups in atmospheric aerosols by infrared spectroscopy: systematic intercomparison of calibration methods for US measurement network samples

Satoshi Takahama, Matteo Reggente

Peak fitting (PF) and partial least squares (PLS) regression have been independently developed for estimation of functional groups (FGs) from Fourier transform infrared (FTIR) spectra of ambient aerosol collected on Teflon filters. PF is a model that quant ...

Copernicus GmbH2019

C-Terminal Bioconjugation of Peptides through Photoredox Catalyzed Decarboxylative Alkynylation

Jérôme Waser, Franck Le Vaillant, Marion Marie-Agnès Garreau

We report the first decarboxylative alkynylation of the C-terminus of peptides starting from free carboxylic acids. The reaction is fast, metal-free, and proceeds cleanly to afford alkynylated peptides with a broad tolerance for the C-terminal amino acid. ...

Wiley-VCH Verlag GmbH2019