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Concept

Truite arc-en-ciel

Publications associées (23)

Organ-specific biotransformation in salmonids: Insight into intrinsic enzyme activity and biotransformation of three micropollutants

Kristin Schirmer

Aquatic ecosystems continue to be threatened by chemical pollution. To what extent organisms are able to cope with chemical exposure depends on their ability to display mechanisms of defense across different organs. Among these mechanisms, biotransformatio ...

Elsevier2024

Effects of water releases and sediment supply on a residual flow reach

Giovanni De Cesare, Robin Schroff

An artificial floods program has been implemented on the Sarine residual flow reach, downstream of the Rossens dam. Two artificial floods were released in 2016 (coupled with sediment augmentation) and in 2020. A natural flood occurred in 2021. The indicato ...

CRC Press/Balkema2023

Evaluation of tire tread particle toxicity to fish using rainbow trout cell lines

Kristin Schirmer, Florian Frédéric Vincent Breider, Benoît Jean Dominique Ferrari, Thibault Béranger Masset, Gabrielle Léger

Tire and road wear particles (TRWP) resulting from tire abrasion while driving raise concerns due to their potential contribution to aquatic toxicity. Our study aimed to assess cryogenically milled tire tread (CMTT) particle toxicity, used as a proxy for T ...

2023

The Bioaccumulation of Ionizable Organic Compounds in Fish Cell Lines

Fabian Gerhard Peter Balk

Bioaccumulation is defined as the enrichment of a compound in an organism relative to the surrounding water or its food, and is an important endpoint in chemical risk assessment. Under laboratory conditions, bioaccumulation is measured as bioconcentration ...

EPFL2023

Bioaccessibility of Organic Compounds Associated with Tire Particles Using a Fish In Vitro Digestive Model: Solubilization Kinetics and Effects of Food Coingestion

Kristin Schirmer, Florian Frédéric Vincent Breider, Dominique Grandjean, Benoît Jean Dominique Ferrari, Thibault Béranger Masset, Luke Christopher Harris

Tire and road wear particles (TRWP) account for an important part of the polymer particles released into the environment. There are scientific knowledge gaps as to the potential bioaccessibility of chemicals associated with TRWP to aquatic organisms. This ...

2022

Wirkungskontrolle einer Sedimentzugabe: Habitatvielfalt und Kolmation

Giovanni De Cesare, Christian Mörtl, Robin Schroff

In einer Restwasserstrecke der Saane wurde 2016 zur Sanierung der kolmatierten Gewässersohle und zur Aufwertung der Lebensräume ein künstliches Hochwasser ausgelöst und mit einer Sedimentzugabe gekoppelt. Die mittelfristigen Wirkungen der Sedimentzugabe wu ...

2021

New Stable Cell Lines Derived from the Proximal and Distal Intestine of Rainbow Trout (Oncorhynchus mykiss) Retain Several Properties Observed In Vivo

Kristin Schirmer

We derived two novel cell lines from rainbow trout (RT) proximal (RTpi-MI) and distal intestine (RTdi-MI) and compared them with the previously established continuous cell line RTgutGC. Intestinal stem cells, differentiating and differentiated epithelial c ...

MDPI2021

In vitro acute toxicity assessment of tire tread particles using rainbow trout cell lines of gill and intestine

Kristin Schirmer, Florian Frédéric Vincent Breider, Benoît Jean Dominique Ferrari, Thibault Béranger Masset

Tire and road wear particles (TRWP) are generated by the abrasion of tires while driving, and recent questions were raised in regards to their potential contribution to microplastics released into the aquatic environment and their potential toxicological i ...

2021

In Vitro Digestion of Tire Particles in a Fish Model (Oncorhynchus mykiss): Solubilization Kinetics of Heavy Metals and Effects of Food Coingestion

Kristin Schirmer, Florian Frédéric Vincent Breider, Benoît Jean Dominique Ferrari, Thibault Béranger Masset

Tire and road wear particles (TRWP) have been shown to represent a large part of anthropogenic particles released into the environment. Nevertheless, the potential ecological risk of TRWP in the different environmental compartments and their potential toxi ...

2021

A ribonucleoprotein transfection strategy for CRISPR/Cas9-mediated gene editing and single cell cloning in rainbow trout cells

Kristin Schirmer

Background The advent of the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 technology marked the beginning of a new era in the field of molecular biology, allowing the efficient and precise creation of targeted mutations in the ge ...

2021

Extending the Concept of Predicting Fish Acute Toxicity In Vitro to the Intestinal Cell Line RTgutGC

Kristin Schirmer, Hannah Inka Schug

Testing chemicals for fish acute toxicity is a legal requirement in many countries as part of environmental risk assessment. To reduce the number of fish used, substantial efforts have been focused on alternative approaches. Prominently, the cell viability ...

2020

Bio-Inspired Tensegrity Fish Robot

Dario Floreano, Jun Shintake, Davide Zappetti

This paper presents a method to create fish-like robots with tensegrity systems and describes a prototype modeled on the body shape of the rainbow trout with a length of 400 mm and a mass of 102 g that is driven by a waterproof servomotor. The structure of ...

IEEE2020

Intestinal Fish Cell Barrier Model to Assess Transfer of Organic Chemicals in Vitro: An Experimental and Computational Study

Kristin Schirmer, Hannah Inka Schug

We studied the role of the fish intestine as a barrier for organic chemicals using the epithelial barrier model built on the rainbow trout (Oncorhynchus mykiss) intestinal cell line, RTgutGC and the newly developed exposure chamber, TransFEr, specifically ...

AMER CHEMICAL SOC2019

Improving a fish intestinal barrier model by combining two rainbow trout cell lines: epithelial RTgutGC and fibroblastic RTgutF

Philippe Renaud, Kristin Schirmer, Hannah Inka Schug, Carolin Drieschner

An in vitro model of the fish intestine is of interest for research and application in diverse fields such as fish physiology, aquaculture and chemical risk assessment. The recently developed epithelial barrier model of the fish intestine relies on the RTg ...

Springer2019

A fish intestinal barrier model to assess the interaction with chemicals in vitro

Hannah Inka Schug

The intestinal epithelium acts as vital gate keeper between the fish and its surrounding environment. A single layer of connected epithelial cells forms a selective barrier, which, among other essential functions, is important for nutrient uptake and defen ...

EPFL2019

Fish-gut-on-chip: development of a microfluidic bioreactor to study the role of the fish intestine in vitro

Philippe Renaud, Kristin Schirmer, Carolin Drieschner, Sarah-Katharina Könemann

In this study we present the first fish-gut-on-chip model. This model is based on the reconstruction of the intestinal barrier by culturing two intestinal cell lines from rainbow trout, namely epithelial RTgutGC and fibroblastic RTgutF, in an artificial mi ...

2019

Effects of altered river network connectivity on the distribution of Salmo trutta: Insights from a metapopulation model

Andrea Rinaldo, Enrico Bertuzzo, Luca Carraro

Network connectivity is a key feature of rivers that affects patterns and processes in lotic ecosystems. Few studies have considered how changes in river reach connectivity might affect ecosystem attributes at a whole river network scale. The use of popula ...

WILEY2019

Sex-specific changes in gene expression in response to estrogen pollution around the onset of sex differentiation in grayling (Salmonidae)

Oliver Michele Selmoni

The synthetic 17 alpha-ethinylestradiol (EE2) is a common estrogenic pollutant that has been suspected to affect the demography of river-dwelling salmonids. One possibility is that exposure to EE2 tips the balance during initial steps of sex differentiatio ...

2019

TransFEr: a new device to measure the transfer of volatile and hydrophobic organic chemicals across an in vitro intestinal fish cell barrier

Kristin Schirmer, Hannah Inka Schug

Transfer of compounds across cellular barriers is a critical step of compound uptake into organisms. Using in vitro barrier systems to evaluate such transfer is attractive because of the higher throughput and reduced resource needs compared to animal studi ...

ROYAL SOC CHEMISTRY2018

What is the role of fish intestine as environment-organism barrier? Mechanistic investigations using fish intestinal cells on a chip

Carolin Drieschner

The gut of fish belongs to the most essential barriers that mark the border between the organism and its surrounding environment. The pivotal barrier function, allowing to absorb nutrients from the diet while simultaneously protecting the organism from pat ...

EPFL2018