Concept

Anterior cervical discectomy and fusion

Anterior cervical discectomy and fusion (ACDF) is a surgical procedure to treat nerve root or spinal cord compression by decompressing the spinal cord and nerve roots of the cervical spine with a discectomy, followed by inter-vertebral fusion to stabilize the corresponding vertebrae. This procedure is used when other non-surgical treatments have failed. ACDF is used to treat serious pain from a nerve root that has become inflamed. This can be caused by:

a herniated disc when other non-surgical treatments have failed. The nucleus pulposus (the jelly-like center of the disc) of the herniated disc bulges out through the annulus (surrounding wall) and presses on the nerve root next to it.
degenerative disc disease (spondylosis). The disc consists of about 80% water. When one grows older, the disc starts to dry out and shrink, causing small tears in the annulus and inflammation of the nerve root. Bone morphogenetic protein (rhBMP) should not be routinely used in any type of anterior cervical spine fusion, such as with anterior cervical discectomy and fusion. There are reports of this therapy causing swelling of soft tissue which in turn can cause life-threatening complications due to difficulty swallowing and pressure on the respiratory tract. The neurosurgeon or orthopedic surgeon enters the space between two discs through a small incision in front (= anterior) of and at the right or left side of the neck. The disc is completely removed, as well as arthritic bone spurs. The disc material, pressing on the spinal nerve or spinal cord, is then completely removed. The intervertebral foramen, the bone channel through which the spinal nerve runs, is then enlarged with a drill giving the nerve more room to exit the spinal canal. To prevent the vertebrae from collapsing and to increase stability, the open space is often filled with a graft. That can be a bone graft, taken from the pelvis or cadaveric bone; or an artificial implant. The slow process of the bone graft joining the vertebrae together is called "fusion".

Source officielle

https://en.wikipedia.org/wiki/Anterior_cervical_discectomy_and_fusion

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Publications associées (1)

Biomechanical investigation of a new implant for cervical spine fusion

Dominique Pioletti, Arne Christian Vogel

The project consists of: - mechanical tests of the prototype of the new implant and comparison to existing anterior fixation systems in a bone model material; - a literature review in order to classify the test results; - the development of a finite element model for the tension case, which will be validated by the mechanical tests.

2007

Personnes associées (7)

Dominique Pioletti

Dominique Pioletti received his Master in Physics from the Swiss Federal Institute of Technology Lausanne (EPFL) in 1992. He pursued his education in the same Institution and obtained his PhD in biomechanics in 1997. He developed original constitutive laws taking into account viscoelasticity in large deformations. Then he spent two years at UCSD as post-doc fellow acquiring know-how in cell and molecular biology. He was interested in particular to gene expression of bone cells in contact to orthopedic implant. In April 2006, Dominique Pioletti was appointed Assistant Professor tenure-track at the EPFL and is director of the Laboratory of Biomechanical Orthopedics. His research topics include biomechanics and tissue engineering of musculo-skeletal tissues; mechano-transduction in bone; development of orthopedic implant as drug delivery system. Since 2013, he has been promoted to the rank of Associate Professor.

Kamiar Aminian

Expertise Biomechanics of human movement Wearable Technology / Inertial sensors Gait Analysis / Physical Activity Monitoring Physical activity Patterns Sport Performance Orthopedics / Rehabilitation engineering Fall Prevention in Elderly Motor function in Parkinson disease Physical behavior in chronic pain Expertise Biomechanics of human movement Wearable Technology / Inertial sensors Gait Analysis / Physical Activity Monitoring Physical activity Patterns Sport Performance Orthopedics / Rehabilitation engin

Charles Baur

Aude Billard

Expertise Machine LearningRoboticsMechatronicsDynamical SystemsComputational Neuroscience Enseignement et PhD Doctorant·es actuel·les Hanli Zhang, Maximilian Schmitz, Luyin Hu, Baiyu Peng, Erfan Etesami, Sthithpragya Gupta, Kuanqi Cai A dirigé les thèses EPFL de Eric Sauser, Sylvain Calinon, Micha Hersch, Florent Günter, Biljana Petreska von Ritter-Zahony, Basilio Noris, Elena Gribovskaya, Seyed Mohammad Khansari Zadeh, Seungsu Kim, Ashwini Shukla, Klas Jonas Alfred Kronander, Luka Lukic, Miao Li, Ravin L

Nikolaos Stergiopoulos

Education MTE, Managing the Technology Enterprise Program (2000), IMD, Lausanne Ph.D. in Biomedical Engineering & Engineering Mechanics (1990) Iowa State University, Ames, Iowa. MS in Biomedical Engineering (1987) Iowa State University, Ames, Iowa. Diploma in Mechanical Engineering (1985) National Technical University of Athens. Professional Activities 2002 - present: Professor and director of LHTC 2010 - present: Founder and director of Rheon Medical SA, Préverenges, Switzerland 2008 - present: Founder and director of Antlia S.A., PSE-C, EPFL campus, Switzerland 1998 - 2007: Founder and Scientific Director of EndoArt S.A., Lausanne, Switzerland 1996 - 2002: Assistant professor at the Biomedical Engineering Laboratory, Swiss Federal Institute of Technology, Lausanne, Switzerland. 1991 - 1996: Research Associate at Swiss Federal Institute of Technology - Lausanne 1990 - 1991: Lecturer, Iowa State University

Alexandre Terrier

Enseignement et PhD Doctorant·es actuel·les Mi-Lane Bouchez, Léa Pistorius A co-dirigé les thèses EPFL de Miguel Gortchacow, Adeliya Latypova, Christoph Anselm Engelhardt, Valérie Malfroy Camine, Yasmine Boulanaache, Pezhman Eghbalishamsabadi Cours Engineering of musculoskeletal system and rehabilitation BIO-687 Numerical methods in biomechanics ME-484 Les étudiants comprennent et appliquent les méthodes numériques (MEF) pour répondre à une question de recherche en biomécan

Pierre-Etienne Bourban

Background 1990 Ingénieur en science des matériaux 1993 PhD in materials science Activities 1993-1994 Research at the Center for Composite Materials, University of Delaware, USA (ccm.udel.edu), SNSF grant Since 1994 Research and teaching at EPFL, Composites, (LTC, LPAC) 1995-1999 Coordination Swiss Priority Program on Materials research: 2.2: Composites Since 1998 Biocomposites 2004-2009 Direction of the EPFL Transdisciplinary programme in Sport and Rehabilitation 2005-2008 Member of the EPFL Vice-Presidency for Innovation and Valorisation and direction a.i.EPFL-LTC Since 2016 Direction Discovery Learning Labs Materials/Bioengineering and Engineering

Concepts associés (1)

Spondylosis

Spondylosis is the degeneration of the vertebral column from any cause. In the more narrow sense it refers to spinal osteoarthritis, the age-related degeneration of the spinal column, which is the most common cause of spondylosis. The degenerative process in osteoarthritis chiefly affects the vertebral bodies, the neural foramina and the facet joints (facet syndrome). If severe, it may cause pressure on the spinal cord or nerve roots with subsequent sensory or motor disturbances, such as pain, paresthesia, imbalance, and muscle weakness in the limbs.

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a herniated disc when other non-surgical treatments have failed. The nucleus pulposus (the jelly-like center of the disc) of the herniated disc bulges out through the annulus (surrounding wall) and presses on the nerve root next to it.
degenerative disc disease (spondylosis). The disc consists of about 80% water. When one grows older, the disc starts to dry out and shrink, causing small tears in the annulus and inflammation of the nerve root. Bone morphogenetic protein (rhBMP) should not be routinely used in any type of anterior cervical spine fusion, such as with anterior cervical discectomy and fusion. There are reports of this therapy causing swelling of soft tissue which in turn can cause life-threatening complications due to difficulty swallowing and pressure on the respiratory tract. The neurosurgeon or orthopedic surgeon enters the space between two discs through a small incision in front (= anterior) of and at the right or left side of the neck. The disc is completely removed, as well as arthritic bone spurs. The disc material, pressing on the spinal nerve or spinal cord, is then completely removed. The intervertebral foramen, the bone channel through which the spinal nerve runs, is then enlarged with a drill giving the nerve more room to exit the spinal canal. To prevent the vertebrae from collapsing and to increase stability, the open space is often filled with a graft. That can be a bone graft, taken from the pelvis or cadaveric bone; or an artificial implant. The slow process of the bone graft joining the vertebrae together is called "fusion".

Source officielle