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Concept

Glucose oxydase

Publications associées (27)

Bioengineering a glucose oxidase nanosensor for near-infrared continuous glucose monitoring

Ardemis Anoush Boghossian, Vitalijs Zubkovs, Nils Schürgers, Hanxuan Wang

Single-walled carbon nanotubes (SWCNTs) emit photostable near-infrared fluorescence that is conducive for optical glucose monitoring. Such SWCNT-based optical sensors often require the immobilization of proteins that can confer glucose selectivity and reac ...

2022

Investigation of physiological roles of AMPK-activated protein kinase y3

Philipp Jurijvic Rhein

Clinical trials have shown that direct activators of an evolutionary-conserved metabolic sensor, AMP-activated protein kinase (AMPK), are beneficial in preventing/treating a range of metabolic disorders, including type 2 diabetes. These activators, includi ...

EPFL2021

Measuring Glycolytic Activity with Hyperpolarized [2H7, U-13C6] D-Glucose in the Naive Mouse Brain under Different Anesthetic Conditions

Rolf Gruetter, Bernard Lanz, Mor-Miri Mishkovsky, Andrea Capozzi, Yves Pilloud, Emmanuelle Ines Flatt

Glucose is the primary fuel for the brain; its metabolism is linked with cerebral function. Different magnetic resonance spectroscopy (MRS) techniques are available to assess glucose metabolism, providing complementary information. Our first aim was to inv ...

2021

Equilibrium and non-equilibrium furanose selection in the ribose isomerisation network

Paolo De Los Rios, Francesco Piazza, Daniel Maria Busiello, Shiling Liang

The exclusive presence of beta -D-ribofuranose in nucleic acids is still a conundrum in prebiotic chemistry, given that pyranose species are substantially more stable at equilibrium. However, a precise characterisation of the relative furanose/pyranose fra ...

Nature Research2021

Protein Bioconjugation to Carbon Nanotubes for Near-Infrared Sensing

Vitalijs Zubkovs

Single-walled carbon nanotubes (SWCNTs) are a promising material for electrochemical and optical biosensing applications. Their small dimensions, large surface area, indefinite photostability, and remarkable electronic properties make SWCNTs an ideal trans ...

EPFL2019

Astrocytic and neuronal oxidative metabolism are coupled to the rate of glutamate-glutamine cycle in the tree shrew visual cortex

João Miguel das Neves Duarte, Rolf Gruetter, Nathalie Just, Sarah Catherine Sonnay

Astrocytes play an important role in glutamatergic neurotransmission, namely by clearing synaptic glutamate and converting it into glutamine that is transferred back to neurons. The rate of this glutamate–glutamine cycle (VNT) has been proposed to couple t ...

Wiley-Blackwell2018

Comparison of liquid hot water (LHW) and high boiling alcohol/water (HBAW) pretreatments for improving enzymatic saccharification of cellulose in bamboo

Li Chen, Li Shuai

Liquid hot water (LHW) and high-boiling point alcohol/water (HBAW) pretreatments were compared to improve enzymatic saccharification of cellulose in moso bamboo. When pretreatments were conducted at 200 degrees C for 40 min, HBAW (20% (v/v) 1,4- butanediol ...

Elsevier Science Bv2017

Enhanced simultaneous saccharification and fermentation of pretreated beech wood by in situ treatment with the white rot fungus Irpex lacteus in a membrane aerated biofilm reactor

Robert Lawrence Shahab

The aim of the present study was to investigate the combination of steam pretreatment and biological treatment with lignin degrading fungal strains in order to enable efficient bioprocessing of beech wood to ethanol. In a sequential process of steam and fu ...

Elsevier2017

Measuring glucose cerebral metabolism in the healthy mouse using hyperpolarized C-13 magnetic resonance

Rolf Gruetter, Arnaud Comment, Mor-Miri Mishkovsky

The mammalian brain relies primarily on glucose as a fuel to meet its high metabolic demand. Among the various techniques used to study cerebral metabolism, C-13 magnetic resonance spectroscopy (MRS) allows following the fate of C-13-enriched substrates th ...

Springer Nature2017

Thermal microsensors for in vitro and in vivo monitoring of chemical and biological processes

Rima Padovani

Metabolism is a highly coordinated biochemical cellular activity indispensable for sustaining life, and is often related to mitochondrial functioning. Innovative technological approaches allowing the study of the thermal signature of chemical and metabolic ...

EPFL2016

New optical tools for non-invasive imaging and quantification of glucose and nicotinamide riboside in living cells and animals

Aleksandra Konovalova

Glucose is one of the most important metabolites that plays a key role in living organisms, as it is the primary energy source. Glucose metabolism is also an integral part in the pathogenesis of diabetes and cancer. Despite this tremendous impact of glucos ...

EPFL2016

Multiscattering-enhanced optical biosensor: multiplexed, non-invasive and continuous measurements of cellular processes

Olivier Martin, Christian Santschi, Volodymyr Koman

The continuous measurement of uptake or release of biomarkers provides invaluable information for understanding and monitoring the metabolism of cells. In this work, a multiscattering-enhanced optical biosensor for the multiplexed, non-invasive, and contin ...

Optical Soc Amer2015

Redefining the metabolic landscape through TGF-beta/Activin signaling in Drosophila melanogaster

Wen Bin Chng

Multicellular organisms assess their nutritional state and adapt their metabolic landscape to match their energy demands. In this thesis, we address a longstanding conundrum of how an organism coordinates digestive enzyme expression in response to its nutr ...

EPFL2015

Nanocalorimetric platform for accurate thermochemical studies in microliter volumes

Martinus Adela Maria Gijs, Thomas Lehnert, Raphaël Etienne Jean Trouillon, Rima Padovani

A straightforward and general way for monitoring chemical reactions is via their thermal signature. Such approach requires however an experimental setup with a high thermal stability that simultaneously allows time-resolved heat detection with high sensiti ...

Royal Soc Chemistry2015

Use of Empty Fruit Bunches from the Oil Palm for bioethanol production: A thorough comparison between dilute acid and dilute alkali pretreatment

Edgard Gnansounou, Simone Chiesa

In the present work, two pretreatment techniques using either dilute acid (H2SO4) or dilute alkali (NaOH) have been compared for producing bioethanol from Empty Fruit Bunches (EFBs) from oil palm tree, a relevant feedstock for tropical countries. Treatment ...

Elsevier2014

Glutamatergic and GABAergic energy metabolism measured in the rat brain by 13C NMR spectroscopy at 14.1 T

João Miguel das Neves Duarte, Rolf Gruetter

Energy metabolism supports both inhibitory and excitatory neurotransmission processes. This study investigated the specific contribution of astrocytic metabolism to γ-aminobutyric acid (GABA) synthesis and inhibitory GABAergic neurotransmission that remain ...

Wiley-Blackwell2013

On chip cellular dielectric spectroscopy : monitoring of glucose effect on erythrocytes membrane and analysis of the physiological role of anthrax toxin receptor in endothelial cells

Ludovica Colella

In the recent years, the development of automated systems for cellular monitoring has been highly promoted in basic biological research as well as in industries and medical diagnostic. Several methods for transduction of cellular signals have been investig ...

EPFL2012

Size-selective diffusion in nanoporous alumina membranes for a glucose affinity sensor

Jean-Michel Sallese, Peter Ryser, Eric Meurville, Christophe Boss

The retention, diffusion and structural properties of 2–4 nm nanoporous alumina membranes were investigated in view of their integration as size-selective interface in a glucose sensor. These membranes exhibit remarkable glucose diffusion properties with o ...

Elsevier2012

A Viscosity-Dependent Affinity Sensor for Continous Monitoring of Glucose in Biological Fluids

Christophe Boss

For fifty years, tremendous efforts have been directed towards the development of glucose sensors for tight glycemic control of diabetic patients. Today, millions of diabetics test their blood glucose level daily, making glucose the most commonly tested an ...

EPFL2012

Microelectrode-based dielectric spectroscopy of glucose effect on erythrocytes

Philippe Renaud, Ludovica Colella

The dielectric response of biconcave erythrocytes exposed to D-glucose and I.-glucose has been investigated using a double array of planar interdigitated microelectrodes on a glass microchip. Erythrocytes are analyzed under physiological conditions suspend ...

2012