Concept

Fibroïne

vignette|400px|Structure primaire de la fibroïne. Les fibroïnes de soie sont des protéines de structure, aussi appelées protéines de soie. Elles appartiennent à la famille des protéines fibreuses. Leur structure de base est en feuillet bêta. Ces protéines sont formées de trois acides aminés : l'alanine (A), la glycine (G) et la sérine (S). Ces acides aminés se retrouvent sous forme de chaînes, alternées tout au long de la molécule. La fibroïne est une protéine insoluble créée par les araignées, les larves de Bombyx mori, d'autres genres de papillons comme Antheraea, Cricula, Samia et Gonometa, et de nombreux autres insectes.

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https://fr.wikipedia.org/wiki/Fibroïne

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Publications associées (3)

Silk Fibroin as a Resist for Thermal Scanning Probe Lithography

We present for the first time nano-scale patterning of silk fibroin with a thermal scanning probe to locally convert water-insoluble crystalline silk into the water-soluble phase. Our first experiments demonstrate silk as a fully water-based resist for thermal scanning probe lithography with an achieved half-pitch resolution of 50.5±3 nm.

2017

Thermal-responsive biodegradable composite membrane for drug delivery application

Drug delivery systems have been engineered in order to improve therapeutic performance and reduce the side effects of conventional delivery system like oral ingestion, subcutaneous injection [1-2]. There exist several types of drug delivery systems, among which the most advanced consist of drug delivery implants [3-5]. As part of the general challenge for implantable smart, hence controllable, drug releasing systems, we present here a study on thermal-responsive biodegradable composite membrane composed of

2017

The effect of lactose-conjugated silk biomaterials on the development of fibrogenic fibroblasts

Boris Hinz

Surface properties of implanted biomaterials can cause fibrotic tissue reactions by stimulating differentiation of host fibroblasts into contractile myofibroblasts. Silk fibroin (SF) protein has been used as biomaterial in pure and blended form. however, i ...

Elsevier2008

Personnes associées (3)

Jürgen Brugger

I am a Professor of Microengineering and co-affiliated to Materials Science. Before joining EPFL I was at the MESA Research Institute of Nanotechnology at the University of Twente in the Netherlands, at the IBM Zurich Research Laboratory, and at the Hitachi Central Research Laboratory, in Tokyo, Japan. I received a Master in Physical-Electronics and a PhD degree from Neuchâtel University, Switzerland. Research in my laboratory focuses on various aspects of MEMS and Nanotechnology. My group contributes to the field at the fundamental level as well as in technological development, as demonstrated by the start-ups that spun off from the lab. In our research, key competences are in micro/nanofabrication, additive micro-manufacturing, new materials for MEMS, increasingly for wearable and biomedical applications. Together with my students and colleagues we published over 200 peer-refereed papers and I had the pleasure to supervise over 25 PhD students. Former students and postdocs have been successful in receiving awards and starting their own scientific careers. I am honoured for the appointment in 2016 as Fellow of the IEEE “For contributions to micro and nano manufacturing technology”. In 2017 my lab was awarded an ERC AdvG in the field of advanced micro-manufacturing.

Dominique Pioletti

Dominique Pioletti received his Master in Physics from the Swiss Federal Institute of Technology Lausanne (EPFL) in 1992. He pursued his education in the same Institution and obtained his PhD in biomechanics in 1997. He developed original constitutive laws taking into account viscoelasticity in large deformations. Then he spent two years at UCSD as post-doc fellow acquiring know-how in cell and molecular biology. He was interested in particular to gene expression of bone cells in contact to orthopedic implant. In April 2006, Dominique Pioletti was appointed Assistant Professor tenure-track at the EPFL and is director of the Laboratory of Biomechanical Orthopedics. His research topics include biomechanics and tissue engineering of musculo-skeletal tissues; mechano-transduction in bone; development of orthopedic implant as drug delivery system. Since 2013, he has been promoted to the rank of Associate Professor.

Pierre-Etienne Bourban

Background 1990 Ingénieur en science des matériaux 1993 PhD in materials science Activities 1993-1994 Research at the Center for Composite Materials, University of Delaware, USA (ccm.udel.edu), SNSF grant Since 1994 Research and teaching at EPFL, Composites, (LTC, LPAC) 1995-1999 Coordination Swiss Priority Program on Materials research: 2.2: Composites Since 1998 Biocomposites 2004-2009 Direction of the EPFL Transdisciplinary programme in Sport and Rehabilitation 2005-2008 Member of the EPFL Vice-Presidency for Innovation and Valorisation and direction a.i.EPFL-LTC Since 2016 Direction Discovery Learning Labs Materials/Bioengineering and Engineering

Unités associées (3)

IMX - Gestion

Laboratoire de microsystèmes 1

Laboratoire des matériaux organiques et macromoléculaires

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