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Concept

Protocol (science)

Publications associées (25)

Translational screening platform to evaluate chemotherapy in combination with focal therapy for retinoblastoma

Paul Joseph Dyson, Valentin Simeonov, Fabien Kuttler, Patrik Aouad, Irina Sinenko

Retinoblastoma is the most common pediatric eye cancer. It is currently treated with a limited number of drugs, adapted from other pediatric cancer treatments. Drug toxicity and relapse of the disease warrant new therapeutic strategies for these young pati ...

WILEY2023

Optimised three-dimensional in vitro retinoblastoma models tailored for drug discovery and clinical translatability

Irina Sinenko

Retinoblastoma, while relatively rare, stands as the most prevalent intraocular cancer. In Switzerland, the survival rate approaches 100%, but it drops to less than 50% in low-income countries. The current treatment options for retinoblastoma rely on a lim ...

EPFL2023

Validating atlas-based lesion disconnectomics in multiple sclerosis: A retrospective multi-centric study

Reto Meuli, Tobias Kober, Bénédicte Marie Maréchal, Jonas Richiardi

The translational potential of MR-based connectivity modelling is limited by the need for advanced diffusion imaging, which is not part of clinical protocols for many diseases. In addition, where diffusion data is available, brain connectivity analyses rel ...

2021

Gait features for discriminating between mobility-limiting musculoskeletal disorders: Lumbar spinal stenosis and knee osteoarthritis

Wei Zhang

Background: Functional ambulation limitations are features of lumbar spinal stenosis (LSS) and knee osteoarthritis (OA). With numerous validated walking assessment protocols and a vast number of spatiotemporal gait parameters available from sensor-based as ...

ELSEVIER IRELAND LTD2020

Decoding Cognitive States under Varying Difficulty Levels

Ping-Keng Jao

Understanding cognitive states of human under different difficulty levels is useful in improving human-human and human-machine interactions. For example, a crucial factor in designing games is maintaining the engagement of players. An ideal scenario would ...

EPFL2020

Tractostorm: The what, why, and how of tractography dissection reproducibility

Alessandro Daducci, Gabriel Girard, David Paul Roger Romascano, Maxime Descoteaux, Muhamed Barakovic

Investigative studies of white matter (WM) brain structures using diffusion MRI (dMRI) tractography frequently require manual WM bundle segmentation, often called "virtual dissection." Human errors and personal decisions make these manual segmentations har ...

Wiley2020

High-resolution H-1 NMR of powdered solids by homonuclear dipolar decoupling

David Lyndon Emsley, Federico Maria Paruzzo

The development of homonuclear dipolar decoupling sequences to obtain high-resolution H-1 NMR spectra from solids has recently celebrated its 50th birthday. Over the years, a series of different decoupling schemes have been developed, starting with the pio ...

Academic Press Inc - Elsevier Science2019

Gangliosides: Treatment Avenues in Neurodegenerative Disease

Pierre Magistretti

Gangliosides are cell membrane components, most abundantly in the central nervous system (CNS) where they exert among others neuro-protective and -restorative functions. Clinical development of ganglioside replacement therapy for several neurodegenerative ...

FRONTIERS MEDIA SA2019

A systematic review and meta-analysis of the efficacy of aortic anastomotic devices

Nikolaos Stergiopoulos

Objective: One of the factors contributing to complications related to open repair of the aorta is the construction of a hand-sewn anastomosis. Aortic anastomotic devices (AADs), such as the intraluminal ringed graft (IRG), and the anastomotic stenting tec ...

MOSBY-ELSEVIER2019

Unified multi-modal characterization of microstructural parameters of brain tissue using diffusion MRI and multi-echo T2 data

Jean-Philippe Thiran, Alessandro Daducci, Erick Jorge Canales Rodriguez, Nicolas Kunz, Marco Pizzolato

In this study, a unified framework to estimate different microstructure indices from diffusion MRI and multi-echo T2 (MET2) data was proposed.The new methodology takes into account the common and complementary information provided by both modalities. While ...

2018

Atomic Force Microscopy of Biological Systems: Quantitative Imaging and Nanomotion Detection

Petar Stupar

The core of this thesis is the application of different modalities of atomic force microscopy to study living systems. After a brief introduction, quantitative imaging state of the art is presented and the applications for mammalian, plant, bacterial, and ...

EPFL2018

Hydro-mechanical characterization of gas shales and Opalinus Clay shale in partially saturated conditions

Alberto Minardi

An experimental study on the behaviour of shales in partially water saturated conditions is presented in this thesis. The Opalinus Clay shale and gas shales from different unconventional reservoirs have been studied. Opalinus Clay is currently considered a ...

EPFL2018

Blind calibration of sensors of sensor arrays

Paul Hurley, Matthieu Martin Jean-André Simeoni

Embodiments include methods for calibrating sensors of one or more sensor arrays. Aspects include accessing one or more beamforming matrices respectively associated to the one or more sensor arrays. Source intensity estimates are obtained for a set of poin ...

2017

Reliability and validity of the inertial sensor-based Timed "Up and Go" test in individuals affected by stroke

Kamiar Aminian, Fabien Massé

The instrumented Timed "Up and Go" test (iTUG) has the potential for playing an important role in providing clinically useful information regarding an individual's balance and mobility that cannot be derived from the original single-outcome Timed "Up and G ...

Rehibilitation Research & Development Service / Rehabilitation Research and Development Service, Department of Veterans Affairs2016

Big answers from small worlds: a user's guide for protist microcosms as a model system in ecology and evolution

Andrea Giometto, Florian Altermatt

Laboratory microcosm experiments using protists as model organisms have a long tradition and are widely used to investigate general concepts in population biology, community ecology and evolutionary biology. Many variables of interest are measured in order ...

Wiley-Blackwell2015

Nanoparticles in medicine: Current challenges facing inorganic nanoparticle toxicity assessments and standardizations

Heinrich Hofmann

Although nanoparticles research is ongoing since more than 30 years, the development of methods and standard protocols required for their safety and efficacy testing for human use is still in development. The review covers questions on toxicity, safety, ri ...

Elsevier2015

Asynchronous detection of error potentials

Inaki Asier Iturrate Gil

Recent developments in brain-machine interfaces (BMIs) have proposed the use of errorrelated potentials as cognitive signal that can provide feedback to control devices or to teach them how to solve a task. Due to the nature of these signals, all the propo ...

2014

A Pipeline Based Approach for Experimental Neuroscience Data Management

The field of neuroscience is witnessing a huge influx of experimental data thanks to the improvements in the data acquisition tools and techniques. Most of this data is being collected by thousands of experimenters located in various institutions around th ...

EPFL2011

Smashing SQUASH-0

Serge Vaudenay, Khaled Ouafi

At the RFID Security Workshop 2007, Adi Shamir presented a new challenge-response protocol well suited for RFIDs, although based on the Rabin public-key cryptosystem. This protocol, which we call SQUASH-0, was using a linear mixing function which was subse ...

Springer2009

Decentralized Polling with Respectable Participants

Rachid Guerraoui, Anne-Marie Kermarrec, Kévin Clément Huguenin, Maxime Monod

We consider the polling problem in a social network where participants care about their reputation: they do not want their vote to be disclosed nor their misbehaving, if any, to be publicly exposed. Assuming this reputation concern, we show that a simple s ...

2009