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Concept

Cataracte (maladie)

Publications associées (24)

Spinodal surface of a free energy model for eye lens protein mixtures: Relevance for cataracts

Giuseppe Foffi, Nicolas Dorsaz

We studied the phase behavior of a model binary mixture of eye lens crystallin proteins using first-order thermodynamic perturbation theory. The instability boundary, or spinodal surface, was found to be very sensitive to the strength of the attraction bet ...

Amer Inst Physics, 2 Huntington Quadrangle, Ste 1No1 D, Melville, Ny 11747-4501 Usa2009

A New Locus for Congenital Cataract, Microcornea, Microphthalmia, and Atypical Iris Coloboma Maps to Chromosome 2

Objective: To report a novel phenotype of autosomal dominant atypical congenital cataract associated with variable expression of microcornea, microphthalmia, and iris coloboma linked to chromosome 2. Molecular analysis of this phenotype may improve our und ...

2009

New insight into cataract formation: Enhanced stability through mutual attraction

Giuseppe Foffi, Nicolas Dorsaz

Small-angle neutron scattering experiments and molecular dynamics simulations combined with an application of concepts from soft matter physics to complex protein mixtures provide new insight into the stability of eye lens protein mixtures. Exploring this ...

2007

Optische Augenlängenmessung für klinische Anwendungen

Beate Möller

Cataract is the leading cause of blindness worldwide. The clouding of the human eye lens is called "Grauer Star" in German. In the industrialized countries this process of increased blindness is corrected by the surgical removal of the clouded lens and its ...

EPFL2001