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Concept

Radiocontrast agent

Publications associées (29)

Functionalization of harmonic nanoparticles for drug release and multimodal imaging applications

Adrian Stefan Gheata

Cancer is among the leading causes of death worldwide, and as knowledge of the disease continues to grow there is an increasing interest towards precision medicine: more specifically towards the theranostics field, i.e the development of targeted molecular ...

EPFL2024

Quantitative T2 Mapping of Acute Pancreatitis

Tom Hilbert

Background: Quantification of the T2 signal by means of T2 mapping in acute pancreatitis (AP) has the potential to quantify the parenchymal edema. Quantitative T2 mapping may overcome the limitations of previously reported scoring systems for reliable asse ...

Wiley2024

Hierarchical Pricing Game for Balancing the Charging of Ride-Hailing Electric Fleets

Nikolaos Geroliminis, Nils Gustav Nilsson, Marko Maljkovic

Due to the ever-increasing popularity of ride-hailing services and the indisputable shift towards alternative fuel vehicles, the intersection of the ride-hailing market and smart electric mobility provides an opportunity to trade different services to achi ...

2023

Gd3+-Functionalized Lithium Niobate Nanoparticles for Dual Multiphoton and Magnetic Resonance Bioimaging

Marinella Mazzanti, Sandrine Gerber, Anne-Sophie Chauvin, Luigi Bonacina, Katarzyna Pierzchala, Ileana Ozana Jelescu, Jérémy Vuilleumier, Raphaël Jovita De Matos, Laura Camille Louise Nicolle, Adrian Stefan Gheata, Dario Diviani

Harmonic nanoparticles (HNPs) have emerged as appealing exogenous probes for optical bioimaging due to their distinctive features such as long-term photostability and spectral flexibility, allowing multiphoton excitation in the classical (NIR-I) and extend ...

2022

Magnetic regulation of the luminescence of hybrid lanthanide-doped nanoparticles

Jean-Claude Bünzli

The unique optical properties of lanthanide-doped nanomaterials have made them broadly attractive to a wide range of applications in chemical, physical, and biomedical fields. As an external and real-time reg-ulation tool, the magnetic field is highly usef ...

ELSEVIER SCIENCE SA2022

Performance and reproducibility of C-13 and N-15 hyperpolarization using a cryogen-free DNP polarizer

Hikari Ananda Infinity Yoshihara

The setup, operational procedures and performance of a cryogen-free device for producing hyperpolarized contrast agents using dissolution dynamic nuclear polarization (dDNP) in a preclinical imaging center is described. The polarization was optimized using ...

Nature Portfolio2022

Multi-antenna 3D pattern design for millimeter-wave vehicular communications

German Augusto Ramirez Arroyave

The transformation of the automotive industry towards ubiquitous connection of vehicles with all kind of external agents (V2X) motivates the use of a wide range of frequencies for several applications. Millimeter-wave (mmWave) connectivity represents a par ...

2022

Robust Phase Unwrapping via Deep Image Prior for Quantitative Phase Imaging

Michaël Unser, Matthias Lütolf, Nathalie Brandenberg, Thanh-An Michel Pham

Quantitative phase imaging (QPI) is an emerging label-free technique that produces images containing morphological and dynamical information without contrast agents. Unfortunately, the phase is wrapped in most imaging system. Phase unwrapping is the comput ...

2021

Biodegradable Harmonophores for Targeted High-Resolution In Vivo Tumor Imaging

Sylvie Roke, Claire Jacqueline Léa Teulon

Optical imaging probes have played a major role in detecting and monitoring a variety of diseases. In particular, nonlinear optical imaging probes, such as second harmonic generating (SHG) nanoprobes, hold great promise as clinical contrast agents, as they ...

2021

Brain micro-vasculature imaging: An unsupervised deep learning algorithm for segmenting mouse brain volume probed by high-resolution phase-contrast X-ray tomography

Alessandra Patera, Anne Bonnin

High-throughput synchrotron-based tomographic microscopy at third generation light sources allows to probe cm-sized samples at micrometer-resolution. In this work, we present an approach to image a full mouse brain. With Indian-ink as a contrast agent, it ...

WILEY2021

In vitro Implementation of Photopolymerizable Hydrogels as a Potential Treatment of Intracranial Aneurysms

Dominique Pioletti, Christophe Moser, Andreas Schmocker, Oriane Poupart

Intracranial aneurysms are increasingly being treated with endovascular therapy, namely coil embolization. Despite being minimally invasive, partial occlusion and recurrence are more frequent compared to open surgical clipping. Therefore, an alternative tr ...

2020

Classification of Metal-Based Drugs according to Their Mechanisms of Action

Paul Joseph Dyson

Metal-based drugs and imaging agents are extensively used in the clinic for the treatment and diagnosis of cancers and a wide range of other diseases. The current clinical arsenal of compounds operate via a limited number of mechanisms, whereas new putativ ...

CELL PRESS2020

Multi T1-weighted contrast MRI with fluid and white matter suppression at 1.5 T

Tobias Kober, Giulio Gambarota

Introduction: The fluid and white matter suppression sequence (FLAWS) provides two T1-weighted co-registered datasets: a white matter (WM) suppressed contrast (FLAWS1) and a cerebrospinal fluid (CSF) suppressed contrast (FLAWS2). FLAWS has the potential to ...

ELSEVIER SCIENCE INC2019

Simultaneous Quantitation of Cationic and Non-ionic Contrast Agents in Articular Cartilage Using Synchrotron MicroCT Imaging

Goran Lovric

Early diagnosis of acute cartilage injuries enables monitoring of disease progression and improved treatment option planning to prevent post-traumatic osteoarthritis. In contrast-enhanced computed tomography (CECT), the changes in cationic agent diffusion ...

Nature Research2019

Pharmacokinetics and biodistribution study of self-assembled Gd-micelles demonstrating blood-pool contrast enhancement for MRI

Lothar Helm, Yohan Van de Looij

Magnetic resonance angiography (MRA) requires the use of contrast agents (CAs) to enable accurate diagnosis. There are currently no CAs on the market with appropriate pharmacokinetic (PK) parameters, namely long persistence in the blood, that can be easily ...

2019

High-Field C-13 Dynamic Nuclear Polarization in Nanodiamond

Stefano Alberti, Jean-Philippe Ansermet, Serguei Sekatski, Jérémy Genoud, Murari Soundararajan, Dongyoung Yoon

Hyperpolarization in diamond via dynamic nuclear polarization (DNP) has attracted a lot of interest for various applications as diamond exhibits extremely long C-13 spin relaxation times and has endogenous polarizing agents in the form of crystalline defec ...

2019

A method for preparing phfs-like tau aggregates

Hilal Lashuel, Nadine Aït Bouziad

The invention relates to a method for preparing PHFs-like Tau aggregates and to a method for identifying compounds that are inhibitors of Tau protein aggregation, blockers of Tau seeding and propagation, and imaging agents that specifically bind PHF. ...

2019

Quantitative phase imaging in biomedicine

Christian Depeursinge

Quantitative phase imaging (QPI) has emerged as a valuable method for investigating cells and tissues. QPI operates on unlabelled specimens and, as such, is complementary to established fluorescence microscopy, exhibiting lower phototoxicity and no photobl ...

Nature Publishing Group2018

Error performances of a model-based biplane fluoroscopic system for tracking knee prosthesis during treadmill gait task

Kamiar Aminian, Arnaud Barré

Roentgen stereophotogrammetry analysis technique allows an accurate measurement of knee joint prosthesis position and orientation using two X-ray images. Although this technique is used generally during static procedure, it is possible to use it with a bip ...

2018

Self-Assembled Nanomicelles as MRI Blood-Pool Contrast Agent

Lothar Helm, Anne-Sophie Chauvin

Gadolinium‐loaded nanomicelles show promise as future magnetic resonance imaging (MRI) contrast agents (CAs). Their increased size and high gadolinium (Gd) loading gives them an edge in proton relaxivity over smaller molecular Gd‐complexes. Their size and ...

2017