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Concept

Bioprospection

Publications associées (4)

Total Synthesis of Fijiolide A via an Atropselective Paracyclophane Formation

Christoph Heinz

The natural product fijiolide A is a secondary metabolite isolated from a marine-derived actinomycete of the genus Nocardiopsis. It displays inhibitory activity against TNF-Î±-induced activation of NFÎºB, an important transcription factor and a potential t ...

EPFL2016

Total Synthesis of Fijiolide A

Nicolai Cramer, Christoph Heinz

Fijiolide A is a secondary metabolite isolated from a marine-derived actinomycete of the genus Nocardiopsis. It was found to significantly reduce the TNF-alpha induced activity of the transcription factor NF kappa B, which is considered a promising target ...

Schweizerische Chemische Gesellschaft2016

Synthesis of Fijiolide A via an Atropselective Paracyclophane Formation

Nicolai Cramer, Christoph Heinz

Fijiolide A is a secondary metabolite isolated from a marine-derived actinomycete and displays inhibitory activity against TNF-α-induced activation of NFκB, an important transcription factor and a potential target for the treatment of different cancers and ...

American Chemical Society2015

New synthetic route toward polyketide-like macrolides

Sandrine Gerber, Gérald Coste

New pathways toward the synthesis of polyketide-like macrolides have been developed through the functionalization of long chain polyolic fragments readily obtained from 3,3'-methylenebis{[6-(benzyloxy)methoxy]cyclohept-3-en-1-ol} derivatives 6. This synthe ...

2006