Concept

Chronic myelomonocytic leukemia

Chronic myelomonocytic leukemia (CMML) is a type of leukemia, which are cancers of the blood-forming cells of the bone marrow. In adults, blood cells are formed in the bone marrow, by a process that is known as haematopoiesis. In CMML, there are increased numbers of monocytes and immature blood cells (blasts) in the peripheral blood and bone marrow, as well as abnormal looking cells (dysplasia) in at least one type of blood cell. CMML shows characteristics of a myelodysplastic syndrome (MDS); a disorder that produces abnormal looking blood cells, and a myeloproliferative neoplasm (MPN); a disorder characterised by the overproduction of blood cells. For this reason, CMML was reclassified as a MDS/MPN overlap disorder in 2002. For a diagnosis of CMML, the World Health Organization (WHO) states that the blood monocyte count must be >1x109/L, no Philadelphia chromosome or mutations in the PDGFRA or PDGFRB gene should be present, the blast count must be 10% and

Source officielle

https://en.wikipedia.org/wiki/Chronic_myelomonocytic_leukemia

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Séances de cours associées (1)

Mécanismes sélectifs de ciblage des médicaments

Explore les mécanismes de ciblage sélectif des médicaments, le développement de la résistance, l'incidence de la tuberculose, les mutations BCR-ABL, les inhibiteurs de la tyrosine kinase, la toxicité des médicaments, les interactions et les études toxicologiques.

Publications associées (9)

Alternative 5‐Azacitidine 5‐Day 100 mg/m 2 Dosage Shows Non‐Inferiority to Classical Schedule for Myelodysplastic Neoplasm (MDS) and Chronic Myelomonocytic Leukaemia (CMML) Treatment

Introduction 5‐Azacitidine (AZA) is a major treatment option for myelodysplastic neoplasms (MDS) and myelodysplastic/myeloproliferative neoplasms (MDS/MPN). Here we evaluate the efficacy and toxicity of an alternative AZA regimen (100 mg/m 2 /day for 5 days/28 days) in 68 patients (51 MDS, 17 MDS/MPN) treated between 2008 and 2018. Results Median patient age was 66 years, with most patients (98%) having intermediate or high‐risk disease. Overall response rate (ORR) was 62% with 22% complete responses (CR).

Wiley2025

Inflammatory predictors of Post-COVID fatigue

The biological mechanisms underlying objective and subjective fatigue in post-COVID syndrome remain unclear. This study investigates whether immune responses during the acute phase of SARS-CoV-2 infection predict fatigue dimensions 6–9 months post-infection. We analyzed serum immune markers from 54 hospitalized patients (mean age: 58.69 ± 10.90 yrs; female: 31 %) and assessed their association with chronic fatigue using general linear mixed models. Elevated levels of IL-1RA, IFNγ, TNFα, and monocyte percent

2025

The immune landscape of tumor-associated macrophage reprogramming

Tumor-associated macrophages (TAMs) generally acquire immunosuppressive and tumor-promoting phenotypes, which may contribute to tumor resistance to immunotherapy. We previously showed that suppression of microRNA activity through genetic Dicer1 inactivation rewires TAM’s transcriptomes and prompts their immunostimulatory activation. This phenotypic switch enhanced recruitment and activation of CD8+ cytotoxic T cells (CTLs) and improved the efficacy of immunotherapy in mouse cancer models. Here, we performed

Cold Spring Harbor Laboratory2024

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Source officielle

https://en.wikipedia.org/wiki/Chronic_myelomonocytic_leukemia

À propos de ce résultat

Séances de cours associées (1)

Mécanismes sélectifs de ciblage des médicaments

Publications associées (9)

Alternative 5‐Azacitidine 5‐Day 100 mg/m 2 Dosage Shows Non‐Inferiority to Classical Schedule for Myelodysplastic Neoplasm (MDS) and Chronic Myelomonocytic Leukaemia (CMML) Treatment

Wiley2025

Inflammatory predictors of Post-COVID fatigue

2025

The immune landscape of tumor-associated macrophage reprogramming

Cold Spring Harbor Laboratory2024

Afficher plus

Personnes associées (4)

Giovanni De Micheli

Expertise Technologies de conception pour les systèmes intégrés, tels que la synthèse, le codesign de HW/SW et la conception de basse puissance. Technologies de conception des systèmes sur les plateformes hétérogènes comprenant les composants électriques, et biologiques. En savoir plus Consulter svp http://si2.epfl.ch/~demichel/ Enseignement et PhD A dirigé les thèses EPFL de Abhishek Garg, Mohamed Haykel Ben Jamaa, Francesco Zanini, Ciprian Seiculescu, Cristina Boero, Hu Xu, Andrea Cavallini, Shashi Kanth

Sandrine Madeleine Suzanne Georgeon

Davide Städler

Sandrine Gerber

Sandrine Gerber studied chemistry at the "Ecole Nationale Supérieure de Chimie de Paris" in France, where she obtained a diploma of chemical engineer in 1993. The same year she obtained a DEA (Master degree) of organic chemistry at the University Pierre et Marie Curie (Paris VI, France). From 1993 to 1996 she did a PhD in organic chemistry under the supervision of Prof. Jean-Pierre Genêt at the Ecole Nationale Supérieure de Chimie de Paris. In 1996, she moved to University of Lausanne for a post-doctoral stay under the supervision of Prof. Pierre Vogel. In 1998, she was appointed Maître-Assistante at the Institute of Organic Chemistry in the University of Lausanne. In 2003, she obtained the habilitation to direct research from the University Pierre et Marie Curie (Paris VI, France). The same year, she was appointed scientific adjunct at the EPFL and senior scientist (Maître d'Enseignement et de Recherche) in 2006. In December 2014, she was promoted to titular professor. Since September 2007, Sandrine Gerber is deputy to the director of the Institute of Chemical Sciences and Engineering (ISIC). She is also member of the Board of Directors of the Swiss Chemical Society. Since 2007, Sandrine Gerber is part-time lecturer at the university of Fribourg. She was awarded the Prize Eugene Schueller in 1997, the Prize Dufour for prospective organic chemistry in 2005 and the Werner Prize 2010. She also received a special mention in recognition of exceptional quality of pedagogic competencies in the teaching of basic sciences, given by the Direction of the School of Biology and Medicine from the University of Lausanne, in 2013. In October 2018, she will receive the Prize for Excellence in Teaching from the section of Chemistry and Chemical Engineering.

Concepts associés (2)

Éosinophilie

Léosinophilie (ou hyperéosinophilie) sanguine se définit comme l'augmentation permanente de la valeur de la numération des polynucléaires éosinophiles au-delà d'un seuil généralement admis de 500 cellules par millimètre cube de sang ().

Leucocytose

La leucocytose, également appelée hyperleucocytose, est une augmentation du nombre de globules blancs dans le sang visible sur une numération de la formule sanguine. Elle est fréquemment le signe d'une réponse inflammatoire à la suite d'une infection mais peut aussi survenir à la suite d'une leucémie ou certaines tumeurs osseuses. Elle peut être caractérisée par une augmentation du nombre de polynucléaires neutrophiles, éosinophiles ou basophiles, du nombre de lymphocytes ou du nombre de monocytes.

Personnes associées (4)

Giovanni De Micheli

Sandrine Madeleine Suzanne Georgeon

Davide Städler

Sandrine Gerber